Establishing Australian Health Based Targets For Microbial Water Quality
Funder
National Health and Medical Research Council
Funding Amount
$174,799.00
Summary
It is of great public health importance to ensure that our drinking water supplies are safe. This is true both for conventional drinking water supplies and for supplies derived from alternative water sources, including water derived from recycled sewage. National guidelines exist for management of drinking water and recycled water supplies, but currently there are no targets for determining whether water has an acceptably low level of infectious agents. This project involves a number of steps to ....It is of great public health importance to ensure that our drinking water supplies are safe. This is true both for conventional drinking water supplies and for supplies derived from alternative water sources, including water derived from recycled sewage. National guidelines exist for management of drinking water and recycled water supplies, but currently there are no targets for determining whether water has an acceptably low level of infectious agents. This project involves a number of steps to develop national consensus on health targets for microbial water qualityRead moreRead less
Improving Risk Assessment For Recycled Water: Domestic Laundries And Recreational Parks
Funder
National Health and Medical Research Council
Funding Amount
$81,250.00
Summary
Recent droughts in Australia have meant that recycled water is becoming increasingly important to ensure the sustainability of our water resources. There are four different classes of recycled water (Class A, B, C and D), depending on the level of microbiological contamination. The potential level of exposure of the population to recycled water determines the class of water suitable for various reuse purposes. The need to address water recycling issues in Australia has resulted in increasing num ....Recent droughts in Australia have meant that recycled water is becoming increasingly important to ensure the sustainability of our water resources. There are four different classes of recycled water (Class A, B, C and D), depending on the level of microbiological contamination. The potential level of exposure of the population to recycled water determines the class of water suitable for various reuse purposes. The need to address water recycling issues in Australia has resulted in increasing numbers of innovative recycling schemes such as dual reticulation systems which supply two qualities of water to households, one of high quality for drinking and a second piped system delivering treated recycled water for non-potable (non-drinking) use. In this project, we will investigate the safety of using recycled water in different situations by using water with different known concentrations of micro-organisms to simulate recycled waters of different classes. Most state health authorities in Australia do not approve the use of recycled water for machine washing because of a lack of safety data, but its use in laundries could significantly reduce the need for high quality drinking water. We will perform experiments to help determine the safety of using recycled water for rinsing clothes during a washing machine cycle. Another use of recycled water is for irrigation of recreational parks. Because of safety concerns, when recycled water of Class B or C is used, some states advocate that the public must wait at least 4 hours after watering before they can gain access. This time period may be unnecessary. We will perform experiments to assess the potential exposure to micro-organisms in grass for park users at different time periods following irrigation with water of various classes. The information obtained from this project will help in the decision-making of health and water regulatory agencies.Read moreRead less
Economic, social and cross cultural issues in non-pharmaceutical protection of front line responders to pandemic influenza and emerging infections. The protection of front line responders in a pandemic is essential to underpin an effective response. This research is the only work internationally which will address a key gap in evidence. This research has major implications for the national stockpile and for management of front line responders in a pandemic. These data are urgently needed, not ju ....Economic, social and cross cultural issues in non-pharmaceutical protection of front line responders to pandemic influenza and emerging infections. The protection of front line responders in a pandemic is essential to underpin an effective response. This research is the only work internationally which will address a key gap in evidence. This research has major implications for the national stockpile and for management of front line responders in a pandemic. These data are urgently needed, not just in Australia, but globally to inform pandemic planning and disease control policy around emerging infections and bioterrorism.Read moreRead less
THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading ....COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeuticsRead moreRead less
Resolving Eosinophil And Inflammatory Heterogeneity In Chronic Allergic Airway Disease For Safer, Effective And Lasting Precision Therapies
Funder
National Health and Medical Research Council
Funding Amount
$1,166,165.00
Summary
Many patients with upper airway inflammation and asthma have poorly controlled disease and are in need of new effective therapies. We have discovered new cell subsets in the airways of these patients. We will use cutting edge single cell and spatial analysis of human tissues to define human allergic disease and inflammatory cells at unprecedented resolution. This will identify new targets for treatment and match patients with effective therapies to facilitate precision therapy.
Making Signalling Through The Tumour Necrosis Factor Receptors Selective For Promoting Neutrophil Antimicrobial Activity
Funder
National Health and Medical Research Council
Funding Amount
$196,312.00
Summary
It is evident to the professional and general community that antibiotic and drug resistance displayed by bacteria is a continuing and growing problem in the treatment of infection with potentially casastrophic effect on the health of our community. This concern is only partly reduced by our potential to develop new antimicrobial agents and vaccines. If we were able to use immunomodulators in a relatively safe and appropriate manner to target and enhance the antimicrobial power of specific compon ....It is evident to the professional and general community that antibiotic and drug resistance displayed by bacteria is a continuing and growing problem in the treatment of infection with potentially casastrophic effect on the health of our community. This concern is only partly reduced by our potential to develop new antimicrobial agents and vaccines. If we were able to use immunomodulators in a relatively safe and appropriate manner to target and enhance the antimicrobial power of specific components of the immune system then this could be exploited in the treatment of infection. While body proteins formed (cytokines) which modify the behaviour of the immune system are being used as pharmaceuticals, their toxic side effects are problematic to the patient. Our project focusses on one of the cytokines, tumor necrosis factor (TNF), which increases the antimicrobial activity of phagocytic cells but in addition can have quite devastating effects on other tissues in the body. This is because when TNF binds to its receptor on cells and tissues it elicits a multitude of signals inside the cell which can also precipitate illness. The purpose of our investigations is to identify which signals are responsible for increasing resistance against infection and which are not. With this information we will then see if it is feasible to selectively stimulate this signal from outside the cell since this has a better chance of succeeding as a pharmaceutical. This task is likely to be achievable since our research team has made some unique observations about TNF signalling characteristics and we have developed a peptide TNF mimetic which shows only the characteristics of increasing antimicrobial activity.Read moreRead less
Comparative Pathophysiology And Clinical Epidemiology Of Knowlesi Malaria
Funder
National Health and Medical Research Council
Funding Amount
$267,172.00
Summary
The simian parasite P. knowlesi is the most common cause of malaria in Malaysia and can cause severe and fatal disease. We are currently conducting a study of all malaria patients admitted to a tertiary referral hospital in Sabah, Malaysia. This will allow us to describe the epidemiological and clinical features of the hospitalised patients, including changes over time. We are also conducting novel pathophysiological studies which will allow us to understand how P. knowlesi causes sever disease.
Using Metagenomics To Determine The Causative Agent(s) Of Tick-Borne Disease In Australia
Funder
National Health and Medical Research Council
Funding Amount
$639,428.00
Summary
Tick-borne disease has emerged as a topical and controversial public health problem in Australia. We will employ state-of-the-art techniques in metagenomics to determine what microbial species (bacteria, viruses and eukaryotes) circulate in Australian ticks and whether these or different microbes are also present in humans diagnosed with tick-borne disease. The data generated will provide key information on whether tick-borne disease has a microbiological cause and, if so, the microbes involved.
Translational Research On Malignant Pleural Effusion And Pleural Infection
Funder
National Health and Medical Research Council
Funding Amount
$487,891.00
Summary
I am a leading researcher in pleural effusions (fluid build-up in the chest) from cancer and infection. I run a multicentre clinical trial team to answer important questions directly relevant to patient care, as well as a lab research group with proven record of discovery new treatment targets. This fellowship will capitalize on platforms I have built and determine best approach to remove effusions, understand etiologic roles of the fluid ultimately to find ways to stop fluid from forming.