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Spirometry And Asthma Management In Children And Adults In General Practice.
Funder
National Health and Medical Research Council
Funding Amount
$500,000.00
Summary
Measurement of airflow obstruction, as measured by spirometry, is a vital element in the management of people with asthma. This study aims to examine the potential benefits to patients of using spirometry in the management of asthma in children and adults.
Analysis Of The Effectiveness Of A Simple, Inexpensive, Saliva-based Caries-risk Test
Funder
National Health and Medical Research Council
Funding Amount
$29,688.00
Summary
The project aims to develop a test with the capacity to identify children at risk of developing caries (dental decay) so they can benefit from preventive care. The effectiveness of the test will be assessed by how well it correlates with currently available tests and whether it can predict caries development in children classified into risk groups on the basis of the test. The test promises to be predictive of caries-risk, inexpensive, easy to interpret and rapid when compared to those currently ....The project aims to develop a test with the capacity to identify children at risk of developing caries (dental decay) so they can benefit from preventive care. The effectiveness of the test will be assessed by how well it correlates with currently available tests and whether it can predict caries development in children classified into risk groups on the basis of the test. The test promises to be predictive of caries-risk, inexpensive, easy to interpret and rapid when compared to those currently available commercially.Read moreRead less
RCT Of Risperidone Versus Haloperidol Versus Placebo With Rescue Haloperidol In Delirium In Palliative Care
Funder
National Health and Medical Research Council
Funding Amount
$50,000.00
Summary
A simple definition of delirium is an acute confusional state that occurs when someone is unwell. It can manifest with many symptoms of varying severity, including confusion, restlessness, poor concentration and disturbance of sleep pattern. Delirium is a common problem when someone is unwell. Experience suggests that medications such as haloperidol and risperidone may be useful in managing these symptoms, however these have not been studied in detail in palliative care. This study is comparing ....A simple definition of delirium is an acute confusional state that occurs when someone is unwell. It can manifest with many symptoms of varying severity, including confusion, restlessness, poor concentration and disturbance of sleep pattern. Delirium is a common problem when someone is unwell. Experience suggests that medications such as haloperidol and risperidone may be useful in managing these symptoms, however these have not been studied in detail in palliative care. This study is comparing the three approaches: use of risperidone given regularly, use of haloperidol given regularly, and use of haloperidol given as needed for symptoms of agitation, hallucinations and restlessness related to delirium in patients being cared for in palliative care settings. This study will compare how well these medications control delirium symptoms (from health professional, patient and caregiver perspectives) and also monitor their side effects over a five-day period, and follow longer term outcomes for 6 months (function and location of care).Read moreRead less
A Type II Diabetes Adn Obesity Prevention Program For Primary School Aged Rural Indigenous Children
Funder
National Health and Medical Research Council
Funding Amount
$1,497,369.00
Summary
This project aims to develop and evaluate the impact of an innovative multi-component community and school-based program for type II diabetes and obesity prevention program for Indigenous and non-Indigenous rural children.
Does Vitamin D Supplementation Reduce Cognitive Decline?
Funder
National Health and Medical Research Council
Funding Amount
$646,601.00
Summary
Australia's population is ageing rapidly and so is the frequency of age-related disorders. Dementia is one of the most frequent mental health disorders of older people and one of the leading causes of years of life lost due to disability in Australia. Mild Cognitive Impairment (MCI) in old age is considered an important clinical state predictive of future cognitive decline. There is increasing evidence that the onset of dementia can be delayed with targeting potentially modifiable risk factors. ....Australia's population is ageing rapidly and so is the frequency of age-related disorders. Dementia is one of the most frequent mental health disorders of older people and one of the leading causes of years of life lost due to disability in Australia. Mild Cognitive Impairment (MCI) in old age is considered an important clinical state predictive of future cognitive decline. There is increasing evidence that the onset of dementia can be delayed with targeting potentially modifiable risk factors. Vitamin D is important for healthy bones and muscle function, but is now also discussed as being important for healthy brain function. The purpose of this randomised placebo-controlled clinical trial is to investigate whether supplementation with vitamin D for 18 months in older adults with MCI who have low vitamin D levels, can help to reduce cognitive decline. 110 older adults with MCI will be randomised (by chance, like the flip of a coin) to either active treatment or placebo. Their cognition (such as memory) performance, quality of life and functional level will be compared at 6, 12, and 18 months. If our hypothesis is confirmed, vitamin D supplementation might prove to be a simple, effective and inexpensive way of delaying cognitive decline in people at risk for dementia. This could lead to the reconsideration of current sun exposure policies in Australia and the more widespread use of food fortification and supplementation.Read moreRead less
Prospective Study Of The Emergence Of Syndromal And Sub Syndromal Anxiety And Depression During Cognitive Decline.
Funder
National Health and Medical Research Council
Funding Amount
$555,696.00
Summary
In older people it is well known that memory impairment and cognitive decline are associated with depression and anxiety. However, it is remains quite uncertain which comes first. For a long time it had been thought that deteriorating brain function associated with ageing and the development of dementia is also the cause of new symptoms of depression and anxiety found in older people. Recently, some evidence has emerged to challenge this hypothesis. So we plan to study this question in detail wi ....In older people it is well known that memory impairment and cognitive decline are associated with depression and anxiety. However, it is remains quite uncertain which comes first. For a long time it had been thought that deteriorating brain function associated with ageing and the development of dementia is also the cause of new symptoms of depression and anxiety found in older people. Recently, some evidence has emerged to challenge this hypothesis. So we plan to study this question in detail with data from an existing longitudinal study of ageing women.Read moreRead less
Identification And Quantification Of Risk Of Falls In Cognitively Impaired Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$530,741.00
Summary
This study represents the first systematic approach to understanding the complex interaction of factors that contribute to risk of falling in cognitively impaired older people. The results will provide much needed information on how to intervene to prevent falls and fractures in this high risk population. In the last decade, 25 randomised controlled trials have been published which show it is possible to prevent falls in older people. However, a major disappointing outcome of research in this fi ....This study represents the first systematic approach to understanding the complex interaction of factors that contribute to risk of falling in cognitively impaired older people. The results will provide much needed information on how to intervene to prevent falls and fractures in this high risk population. In the last decade, 25 randomised controlled trials have been published which show it is possible to prevent falls in older people. However, a major disappointing outcome of research in this field is that trials that have included or specifically focused on older people with cognitive impairment have been unsuccessful in preventing falls. Cognitive impairment has long been known to be a major risk factor for falls and fractures but little research has been undertaken to understand the underlying mechanisms as to why this is the case. It is likely that previous falls prevention trials involving people with cognitive impairment were unsuccessful because they did not directly assess mechanisms for falls in this group and simply translated intervention strategies from studies undertaken in cognitively intact older people. This study aims to develop our understanding of the important factors that contribute to risk of falling in older people with cognitive impairment and dementia. Participants will be recruited from a number of sources including hospitals, out-patient clinics, retirement villages, hostels etc. Whilst some participants will be able to consent to take part, all participants must have a nominated person responsible. Consenting participants will undergo a series of assessments, the majority of which can be undertaken in their own home. These will include medical and medication history, measures of gait and balance and tests assessing performance of different regions of the brain. An MRI scan will allow us to determine whether risk of falling relates to any specific pathology in different parts of the brain. We anticipate that we will be able to identify which risk factors and underlying mechanisms are most strongly associated with falling in cognitively impaired older people. We then hope to use the information to design targeted and tailored intervention strategies to reduce falls and fractures in this high risk population.Read moreRead less
An Efficacy Study Of A Cognitive-communicative Intervention To Improve Transition To Residential Care In Dementia
Funder
National Health and Medical Research Council
Funding Amount
$681,083.00
Summary
The transition from home to a residential aged care facility (RACF) is a potentially traumatic process that has a negative impact on the health and well-being of both people with dementia and their caregivers. This project will develop an intervention program for people with dementia that maximizes their ability to learn and retain functional skills and that enhances the communicative competence of both people with dementia and their carergivers. This will serve to minimize the stress and disori ....The transition from home to a residential aged care facility (RACF) is a potentially traumatic process that has a negative impact on the health and well-being of both people with dementia and their caregivers. This project will develop an intervention program for people with dementia that maximizes their ability to learn and retain functional skills and that enhances the communicative competence of both people with dementia and their carergivers. This will serve to minimize the stress and disorientation, as well as accompanying increased risk of illness, of entering residential care. We will investigate whether this intervention program has good outcomes both for the people with dementia as well as their caregivers. The research will develop guidelines for the development of best-practice policies for service providers and the government, which will assist both health workers and homebased caregivers to better manage the transition of people with dementia from home to the RACF environment.Read moreRead less