Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Postviral Wheezing In Childhood: Disregulation Of Airway Tone?
Funder
National Health and Medical Research Council
Funding Amount
$577,040.00
Summary
Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. Ho ....Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. However, many infants who wheeze with viral infections, especially in the first year of life, do not develop allergies in later life, raising the possibility that they did not have the same type of asthma as those whose symptoms persist. This project will study the effects of viral infections on lung function to determine whether particular types of virus can have detrimental effects of lung function lasting for years. We will also examine whether the age at which the infection occurs and the severity of the infection influence the long-term outcome. The project involves studying infants during the recovery phase of respiratory viral infections, older children years after documented infections and experimental animal models that have been infected under controlled conditions. By determining whether respiratory viral infections can have long-term effects on lung function that can mimic asthma, we will advance our understanding of how asthma develops. In addition, specific treatment and preventative strategies could then be developed to prevent these long-term abnormalities, instead of relying on asthma medication (especially inhaled corticosteroids) as is the current practice. Preventative strategies could include encouraging the development of specific vaccines.Read moreRead less
Envisaging Citizenship: Australian Histories and Global Connections. This project aims to investigate the ways that visual images have defined, contested and advanced ideas of Australian citizenship and rights from European settlement to the present. Responding to the lack of a shared mainstream understanding of Australian citizenship, it looks beyond legal definitions to explore cultural and especially visual views of citizenship over time. Through collaboration with museum, media and education ....Envisaging Citizenship: Australian Histories and Global Connections. This project aims to investigate the ways that visual images have defined, contested and advanced ideas of Australian citizenship and rights from European settlement to the present. Responding to the lack of a shared mainstream understanding of Australian citizenship, it looks beyond legal definitions to explore cultural and especially visual views of citizenship over time. Through collaboration with museum, media and education sectors, it will provide a forward-looking and accessible public history, and utilise the potential of images to broaden contemporary debates about citizenship. Expected outcomes include a better public understanding of the pathways to citizenship, and enhanced engagement with Australian values and identity.Read moreRead less
Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. Th ....Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. The success of this project will further enhance the international competitiveness of Australian research in this important field and will benefit any Australian industry and business where software systems are deeply-rooted, such as transportation, smart homes, medical devices, defence and finance.Read moreRead less
The Long-term Consequences Of Assisted Reproduction On The Growth, Metabolic, Respiratory, Psychological, Immunological And Reproductive Development Of The Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$1,552,096.00
Summary
1 in 25 children are born from IVF treatment - incredibly- to our shame; no data exists as to the long-term health of these children. Presented is a unique opportunity, which would be exceedingly difficult to replicate elsewhere in the world, to determine the long-term consequences of IVF upon the development of the offspring, by comparing their growth, metabolic, respiratory, psychological, immunological and reproductive development to a representative sample of WA children- the Raine cohort.
Discovery Early Career Researcher Award - Grant ID: DE190101043
Funder
Australian Research Council
Funding Amount
$404,956.00
Summary
Tackling facial prejudice. This project aims to investigate individual differences in facial prejudice, a powerful psychological bias whereby people rely on inaccurate first impressions to guide key decisions, such as whom to trust. Utilising recent advances in electrophysiology, the project will develop a new neural marker of individual differences in facial impressions that lead to prejudice. The project expects to lead to insights into the link between visual perception and social behaviour, ....Tackling facial prejudice. This project aims to investigate individual differences in facial prejudice, a powerful psychological bias whereby people rely on inaccurate first impressions to guide key decisions, such as whom to trust. Utilising recent advances in electrophysiology, the project will develop a new neural marker of individual differences in facial impressions that lead to prejudice. The project expects to lead to insights into the link between visual perception and social behaviour, and to develop strategies to reduce facial prejudice given the pervasive influence it has on everyday life.Read moreRead less
In-vivo functional imaging of cone photoreceptors and ganglion cell axons. Can we project a movie on a human retina, and measure the response of photoreceptor cells and connected nerve tissue? This project aims to investigate a new method for visualization of the quickest responses in human cone photoreceptors and nerve cells after a visible stimulus. Expected outcomes of this project include a better understanding of the origins of responses to a stimulus and how cells in the retina communicate ....In-vivo functional imaging of cone photoreceptors and ganglion cell axons. Can we project a movie on a human retina, and measure the response of photoreceptor cells and connected nerve tissue? This project aims to investigate a new method for visualization of the quickest responses in human cone photoreceptors and nerve cells after a visible stimulus. Expected outcomes of this project include a better understanding of the origins of responses to a stimulus and how cells in the retina communicate. The scientific results will be helpful in a better understanding of the development of vision in the infant eye, to study peripheral vision in elite athletes and to quantify performance of virtual reality equipment for the military. The IP on the technology can be licensed or used for start-up company.Read moreRead less
Who may judge a book by its cover? This project aims to build a model of how and why people vary in their impressions of others and in the accuracy of these impressions. People readily form impressions of others from their faces and these impressions influence crucial decisions: election results, court case outcomes and partner choices. To build this model, the project will apply twin data and construct a psychometric test to measure variation in facial impressions. The research is expected to l ....Who may judge a book by its cover? This project aims to build a model of how and why people vary in their impressions of others and in the accuracy of these impressions. People readily form impressions of others from their faces and these impressions influence crucial decisions: election results, court case outcomes and partner choices. To build this model, the project will apply twin data and construct a psychometric test to measure variation in facial impressions. The research is expected to lead to insights into this aspect of social perception, and to identify the sources of atypical or inaccurate facial judgements. This has applications in health contexts (to identify social impairment) and in security contexts (for personnel selection).Read moreRead less
Old Atrocities, New Media: Terror Images and the Visual-Military Complex. This research centres on the relations between twenty-first century visual technologies and the age-old practice of the massacre-atrocity. It takes as its major case study the atrocities at the end of the war in Sri Lanka in 2009. The most graphic form of knowledge about these mass deaths and rapes was produced through digitally transmitted visual images. The research asks how new forms of recording and circulating images ....Old Atrocities, New Media: Terror Images and the Visual-Military Complex. This research centres on the relations between twenty-first century visual technologies and the age-old practice of the massacre-atrocity. It takes as its major case study the atrocities at the end of the war in Sri Lanka in 2009. The most graphic form of knowledge about these mass deaths and rapes was produced through digitally transmitted visual images. The research asks how new forms of recording and circulating images of atrocity, whether in the form of trophy photographs or other digital documents, shape the reception of, and responses to, atrocity. These questions are contextualised against a broader examination of the historical and evolving relations between visual media and atrocity images from the Holocaust to Abu Ghraib.Read moreRead less