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Novel Functional Testing For Early Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$447,578.00
Summary
About 7.5% of Australians have diabetes and 62% of them will have signs of damage to their eyes within 6 years of diagnosis. Diabetes is 2 to 3 times more common amongst Aboriginal Australians. A group of researchers at the Australian National University are collaborating to bring a new test for the severity of diabetic eye disease to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them recognize sight-threatening damage and to assist in t ....About 7.5% of Australians have diabetes and 62% of them will have signs of damage to their eyes within 6 years of diagnosis. Diabetes is 2 to 3 times more common amongst Aboriginal Australians. A group of researchers at the Australian National University are collaborating to bring a new test for the severity of diabetic eye disease to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them recognize sight-threatening damage and to assist in treatment.Read moreRead less
Controlling Neuroinflammation In Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$639,577.00
Summary
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, with 269,000 Australians currently diagnosed with AD and is expected to soar to about 981,000 by 2050. AD accounts for greater than 60% of all cases of dementia. This grant investigates the role that neuroinflammation plays in the progression and exacerbation of AD and will identify new therapeutic strategies to combat this insidious disease.
A New Paradigm For Class I Cytokine Receptor Activation
Funder
National Health and Medical Research Council
Funding Amount
$954,946.00
Summary
Class I cytokine receptors include around 30 receptors with diverse functions such as controlling metabolism and inflammation. Cytokine receptors are molecular switches on cells that receive signals from other cells and transmit this signal into the cell’s nucleus to control the regulation of genes. This project will determine the molecular mechanisms involved in class I cytokine receptors and use this knowledge to develop novel ways to modulate these receptors for clinical applications.
The Preferential Release Of Young Insulin Secretory Granules.
Funder
National Health and Medical Research Council
Funding Amount
$670,005.00
Summary
The aim of this study is to investigate the cause of reduced glucose induced insulin secretion in type 2 diabetes. In pancreatic beta-cells, insulin is packaged and stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that insulin SGs exist in two functionally distinct pools; and one pool is preferentially secreted upon stimulation. How a cell can differentiate the two SG pools is unclear, and we will address this issue in this project.
Controlling Neuroinflammation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Summary
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, with 269,000 Australians currently diagnosed with AD and is expected to soar to about 981,000 by 2050. AD accounts for greater than 60% of all cases of dementia. This grant investigates the role that neuroinflammation plays in the progression and exacerbation of AD and will identify new therapeutic strategies to combat this insidious disease.
The Role Of Cellular Microdomains In G-protein Coupled Receptor Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$385,297.00
Summary
Molecules communicate with cells by attaching to proteins called receptors on the outside of cells, and triggering a series of events inside the cell. These events initially include the assembly of multiple proteins at the cell surface. This project will examine the formation of receptors and other proteins into these ‘communication complexes’. This will provide novel targets for more selective drug development.
Contemporary Australian Photography 1980 to the present. Contemporary Australian art photography has burgeoned over the last 25 years but there is no dedicated book length study in the field. This project will fill this gap by putting Australian photography on an international scholarly agenda, which will generate more scholarship on Australian work. It will have enormous national and community benefit for Australian artists, curators and dealers and the general public who are keenly interested ....Contemporary Australian Photography 1980 to the present. Contemporary Australian art photography has burgeoned over the last 25 years but there is no dedicated book length study in the field. This project will fill this gap by putting Australian photography on an international scholarly agenda, which will generate more scholarship on Australian work. It will have enormous national and community benefit for Australian artists, curators and dealers and the general public who are keenly interested in photography. Read moreRead less
Care and Repair: Rethinking Contemporary Curation for Conditions of Crisis. This project aims to address the significant challenge of how to curate contemporary art under conditions of crisis, made acute by the pandemic. It expects to generate new knowledge in the growth areas of contemporary art and curatorial practice, which will be translatable to creative industries seeking solutions to similar challenges. Anticipated outcomes include new models for sustainable, future-oriented creative prac ....Care and Repair: Rethinking Contemporary Curation for Conditions of Crisis. This project aims to address the significant challenge of how to curate contemporary art under conditions of crisis, made acute by the pandemic. It expects to generate new knowledge in the growth areas of contemporary art and curatorial practice, which will be translatable to creative industries seeking solutions to similar challenges. Anticipated outcomes include new models for sustainable, future-oriented creative practice; a stronger international profile for Australian artists and curators; and the establishment of a regional network of artists and curators between Australia and Southeast Asia. This should significantly aid our understanding of how to meet current and future challenges to producers and audiences of contemporary art.Read moreRead less
Real-time Porosity: Using computer gaming technology to map and analyse pedestrian movement in public and private space. This project will make a major, and ongoing, contribution to our understanding of urban space in a major Australian city. The Porosity Lenses will enable a more complete understanding of pedestrian movement that the Emergency Information Coordination Unit (EICU) believes will directly contribute to protecting Australia from terrorism and crime. In the case of terrorism the soc ....Real-time Porosity: Using computer gaming technology to map and analyse pedestrian movement in public and private space. This project will make a major, and ongoing, contribution to our understanding of urban space in a major Australian city. The Porosity Lenses will enable a more complete understanding of pedestrian movement that the Emergency Information Coordination Unit (EICU) believes will directly contribute to protecting Australia from terrorism and crime. In the case of terrorism the socio/economic benefits of even the smallest success can be immeasurable. The need to anticipate and mitigate the impact of catastrophic events on the city will be balanced, in this study, by a concern to maintain freedom of circulation and promote civic opportunities within previously under-utilised zones.Read moreRead less
Experiencing space: sensory encounters from Baroque Rome to neo-baroque Las Vegas. This project focuses on the historical baroque and the neo-baroque and the relationship between them. The aim of the project is to apply a new methodology to the study of baroque and neo-baroque cultures, one grounded in sensory and spatial approaches. The primary case studies will be the cities of Rome and Las Vegas, two cities that are paradigmatic of the baroque and the neo-baroque. Whereas for theorists such a ....Experiencing space: sensory encounters from Baroque Rome to neo-baroque Las Vegas. This project focuses on the historical baroque and the neo-baroque and the relationship between them. The aim of the project is to apply a new methodology to the study of baroque and neo-baroque cultures, one grounded in sensory and spatial approaches. The primary case studies will be the cities of Rome and Las Vegas, two cities that are paradigmatic of the baroque and the neo-baroque. Whereas for theorists such as Jean Baudrillard argue that Las Vegas embodies the postmodern world in excess, this project will instead argue that it is emblematic of the return of a baroque aesthetics that has been nurtured by consumer culture, multi-media conglomeration and digital technology.Read moreRead less