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Determining the molecular regulation of blood vessel development and angiogenesis. Abnormal blood vessel growth is associated with diseases including cancer, macular degeneration, diabetic retinopathy and chronic inflammation. This project focuses on understanding normal blood vessel growth in order to gather clues to help discover ways of preventing abnormal blood vessel growth during disease.
Small heat-shock molecular chaperone proteins and amyloid fibrils. This proposal addresses the fundamental mechanisms of protein aggregation associated with debilitating age-related diseases, e.g. Alzheimer's, Parkinson's and cataract, and the prevention of aggregation via the action of a group of molecular chaperone proteins known as small heat-shock proteins. With the ageing population, the prevalence of these diseases will increase significantly over the next 20 years. Understanding and treat ....Small heat-shock molecular chaperone proteins and amyloid fibrils. This proposal addresses the fundamental mechanisms of protein aggregation associated with debilitating age-related diseases, e.g. Alzheimer's, Parkinson's and cataract, and the prevention of aggregation via the action of a group of molecular chaperone proteins known as small heat-shock proteins. With the ageing population, the prevalence of these diseases will increase significantly over the next 20 years. Understanding and treating these diseases will therefore have significant long-term health benefits. Furthermore, the highly structured protein aggregates that form as hallmarks of many of these diseases have potential wide ranging applications in the emerging field of bionanotechnology, e.g. as nanowires and biofilms.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101424
Funder
Australian Research Council
Funding Amount
$434,282.00
Summary
Molecular basis of Prestin’s electromotility and sound discrimination . Sonar animals like whales can hear at exceptionally high frequencies allowing them to echolocate. Humans, though, can hear at much higher frequencies than reptiles and birds. Frequency sensing mainly depends on a protein in the ear called Prestin. Currently, the structure and working mechanism of Prestin is unknown. This project aims to characterize how Prestin responds to high frequencies by probing the electro-mechanical f ....Molecular basis of Prestin’s electromotility and sound discrimination . Sonar animals like whales can hear at exceptionally high frequencies allowing them to echolocate. Humans, though, can hear at much higher frequencies than reptiles and birds. Frequency sensing mainly depends on a protein in the ear called Prestin. Currently, the structure and working mechanism of Prestin is unknown. This project aims to characterize how Prestin responds to high frequencies by probing the electro-mechanical force generated using mechanically gated channels as a reporter. Single particle cryo-electron microscopy will also be used to visualize Prestin’s 3D structure. Together, this DECRA project will elucidate the molecular basis of hearing differences across species and reshapes our understanding of the evolution of hearing.Read moreRead less
Mechanisms Of Nedd4/Nedd4-2-mediated Regulation Of The Epithelial Sodium Channel
Funder
National Health and Medical Research Council
Funding Amount
$471,000.00
Summary
The epithelial sodium channel (ENaC) is a highly specific ion channel expressed in the apical membrane of some tissues. In the kidney, ENaC activity is responsible for maintaining sodium balance, blood volume and blood pressure. In the lung ENaC function is required for fluid clearance. Abnormal regulation of ENaC is associated with conditions such as hypertension, cystic fibrosis and pulmonary oedema. Delineating the molecular basis of the regulation of ENaC is vital in understanding disease me ....The epithelial sodium channel (ENaC) is a highly specific ion channel expressed in the apical membrane of some tissues. In the kidney, ENaC activity is responsible for maintaining sodium balance, blood volume and blood pressure. In the lung ENaC function is required for fluid clearance. Abnormal regulation of ENaC is associated with conditions such as hypertension, cystic fibrosis and pulmonary oedema. Delineating the molecular basis of the regulation of ENaC is vital in understanding disease mechanisms and in defining targets for novel therapeutics for the treatment of disorders that arise due to sodium imbalance. Furthermore, ENaC and the molecules involved in the channel regulatory cascade are potential candidate genes in defining the genetic causes of human hypertension and salt wasting disorders. Previous studies from our laboratories and by other groups have shown that Nedd4 and Nedd4-2 proteins are key players in regulating ENaC activity. Our recent NHMRC supported work has identified another important protein, Grk2, as a regulator of ENaC. The work proposed in this application is an extension of our recent findings and will enable us to fully define how Nedd4-Nedd4-2 and Grk2 regulate the activity of ENaC.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100203
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Accessing the third dimension in scanning electron microscopy for rapid, high resolution tomography of large samples. Understanding the three-dimensional structure of materials is essential for modern research. This facility will allow rapid three-dimensional imaging of materials within a scanning electron microscope, including sustainable polymers, tissues from plants and nanocomposites. This will enable high-quality research in science, engineering and medicine.