Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Discovery Early Career Researcher Award - Grant ID: DE240100967
Funder
Australian Research Council
Funding Amount
$366,000.00
Summary
Open-world computer vision by detecting and tracking hierarchical objects. This project examines the problem of detecting and tracking objects using computer vision. A fundamental limitation of current algorithms is that they require labelled training data for every object class and therefore cannot be trusted to operate in unconstrained environments. This project aims to address this limitation using novel techniques that incorporate hierarchical relationships between object classes. Expected o ....Open-world computer vision by detecting and tracking hierarchical objects. This project examines the problem of detecting and tracking objects using computer vision. A fundamental limitation of current algorithms is that they require labelled training data for every object class and therefore cannot be trusted to operate in unconstrained environments. This project aims to address this limitation using novel techniques that incorporate hierarchical relationships between object classes. Expected outcomes include new paradigms for algorithm design and evaluation, and establishing the problem as a focus of international research. The key practical benefit would be to accelerate the wider deployment of visual perception in applications such as autonomous vehicles, interactive robotics, and video analysis.Read moreRead less
Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is ....Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is applicable in a range of areas, with applications in miniature unmanned vehicles and collision avoidance detectors in defence and civilian roles. Our project could also assist in the development of artificial intelligence and as a basis for designing implantable artificial eyes.Read moreRead less
Vision performance in relationship to spectacle lens design. Refractive errors such as short-sightedness, long-sightedness or presbyopia (age related decline in near vision) are the leading causes of visual impairment in the world. Of these, presbyopia affects almost 100% of the population above 45 years of age. This represents over 40% of all Australians. Although spectacles provide a safe and easy means of correcting refractive errors, they affect quality of life due to distorted vision, disco ....Vision performance in relationship to spectacle lens design. Refractive errors such as short-sightedness, long-sightedness or presbyopia (age related decline in near vision) are the leading causes of visual impairment in the world. Of these, presbyopia affects almost 100% of the population above 45 years of age. This represents over 40% of all Australians. Although spectacles provide a safe and easy means of correcting refractive errors, they affect quality of life due to distorted vision, discomfort such as head and neck ache and cosmetic effects. The goals of the project are to better understand the visual performance of young and old people who wear glasses and to develop improved spectacle lens designs to provide clear and comfortable vision over a range of distances.Read moreRead less
Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth fac ....Development of a novel biodegradable ophthalmic biomaterial based on porous silicon. Within this interdisciplinary project, we will combine our diverse expertise towards the development of frontier technologies for control of stem cell behaviour on biodegradable scaffold materials. We will develop a novel ophthalmic bioimplant from porous silicon using topographical and chemical aspects of surface modification as well as immobilisation and/or incorporation of bioactive species such as growth factors, to permit the growth and differentiation of mammalian stem cells. This project will result in biomaterials for the treatment of blinding diseases of the eye. Implanted into the limbus, bioimplants may ameliorate some common corneal diseases.Read moreRead less
Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases th ....Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases that threaten vision. This project will investigate molecular activities of retinal endothelial cells that are relevant to retinal disease processes and explore future biological therapies directed against the human retinal endothelial cell that address efficacy and safety deficiencies of current treatments.Read moreRead less
Autocalibration without decimation. The insertion of computer generated characters into real footage, the removal of objects from video, and the recovery of 3-dimensional architectural or topographic models from photographs are amongst a growing number of processes used in industry which require highly accurate camera calibration. Autocalibration is thus a prerequisite for these and many other emerging image-based technologies. By developing expertise in this area, and particularly by enabling ....Autocalibration without decimation. The insertion of computer generated characters into real footage, the removal of objects from video, and the recovery of 3-dimensional architectural or topographic models from photographs are amongst a growing number of processes used in industry which require highly accurate camera calibration. Autocalibration is thus a prerequisite for these and many other emerging image-based technologies. By developing expertise in this area, and particularly by enabling more flexible and efficient means of autocalibration, we expect to provide Australian industry with a valuable improvement in the state of the art and a competitive edge in a number of important application areas.Read moreRead less
Combined shape and appearance descriptors for visual object recognition. The quantity of video generated each year is expanding rapidly. This increasing volume of visual information means that it is more likely that any particular event will be recorded, but that the footage will be harder to find. This applies to a collection of home videos as much as to television and movie footage. The object-recognition method to be developed has the potential to alleviate this situation, in which vast amou ....Combined shape and appearance descriptors for visual object recognition. The quantity of video generated each year is expanding rapidly. This increasing volume of visual information means that it is more likely that any particular event will be recorded, but that the footage will be harder to find. This applies to a collection of home videos as much as to television and movie footage. The object-recognition method to be developed has the potential to alleviate this situation, in which vast amounts of video data are available but have little value. Such an outcome would be a boon for Australian industry and offer a valuable export opportunity.Read moreRead less
Multi-objective parameter estimation techniques for computer vision. This project will benefit Australia's scientific knowledge and technology base in the area of computer vision. By contributing improved methods for parameter estimation applicable to a wide variety of technical problems, the project will aid the generation of improved software products in a wide variety of domains. Examples include: augmented reality systems, with which virtual reality artifacts may be immersed within real vid ....Multi-objective parameter estimation techniques for computer vision. This project will benefit Australia's scientific knowledge and technology base in the area of computer vision. By contributing improved methods for parameter estimation applicable to a wide variety of technical problems, the project will aid the generation of improved software products in a wide variety of domains. Examples include: augmented reality systems, with which virtual reality artifacts may be immersed within real video; 3D from 2D systems, with which 3D object structure may be computed from image streams; and visual robotic systems, with which the pose of viewed objects may be determined.Read moreRead less