Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Industrial Transformation Research Hubs - Grant ID: IH180100002
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. Thes ....ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. These dynamic systems will help determine what goal to achieve and the most efficient plan to achieve it. This Hub is expected to contribute to higher farming efficiency, lower production costs and fewer disease risks, giving the Australian industry new business opportunities and an international competitive advantage.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ ....Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ immobilisation. This approach offers flexibility in optimising a number of parameters of the column and of its use for sample pre-treatment and preconcentration. Pulsed potentiometric detection will be developed for the abovementioned microseparation techniques, combining the advantages of pulsed amperometric techniques with the more universally responding potentiometric detection.Read moreRead less
Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed g ....Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed global public response to challenges posed by genome editing. Research will test the effects of the deliberative documentary on viewers, examining benefits of communicating complex issues via the work of the GCA. Other benefits include improving public trust in governance and advancing the Australian film industry.
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Polymer Inclusion Membranes for Electrokinetic Sampling and Separation. This proposal aims to understand the chemical and physical properties governing the transport of ions into and within advanced extracting polymeric materials, known as polymer inclusion membranes, under the influence of an applied voltage. These membranes are dry-to-touch and represent a new and potentially powerful analytical platform for environmental, medical and industry sample preparation. By understanding the transport ....Polymer Inclusion Membranes for Electrokinetic Sampling and Separation. This proposal aims to understand the chemical and physical properties governing the transport of ions into and within advanced extracting polymeric materials, known as polymer inclusion membranes, under the influence of an applied voltage. These membranes are dry-to-touch and represent a new and potentially powerful analytical platform for environmental, medical and industry sample preparation. By understanding the transport mechanism, new membranes will be developed, capable of purifying and concentrating diverse targets chemicals from liquid and solid samples. These processes can take place during sample transportation to a centralised laboratory thus simplifying and streamlining analysis upon arrival to decrease drastically its costs.Read moreRead less
Deliberative Democracy and Citizenship: A Study of Deliberative Polling and Participatory Budgeting in China. The result of this research will enhance Australian democracy-promotion activities overseas, foster Chinese learning from Australian deliberative democratic experiences, as well as benefiting Australian governmental agencies such as AusAID and Australian NGOs working in this field. The project will also strengthen cooperation between Australian researchers and their counterparts in China ....Deliberative Democracy and Citizenship: A Study of Deliberative Polling and Participatory Budgeting in China. The result of this research will enhance Australian democracy-promotion activities overseas, foster Chinese learning from Australian deliberative democratic experiences, as well as benefiting Australian governmental agencies such as AusAID and Australian NGOs working in this field. The project will also strengthen cooperation between Australian researchers and their counterparts in China. The lessons learned from this Chinese experiment can be used to improve the quality of citizen participation and to develop more effective means of public participation and consultation in Australia. The project will contribute to the Australian government's dialogue approach to human rights issues in China since 1989.Read moreRead less
Western Theory of Deliberative Democracy and Chinese Practice of Participatory and Deliberative Institutions. This project is aimed to study how various participatory and deliberative institutions are pursued and promoted by peasants and residents in local governance in China. It is the first study that builds a bridge between Western theory of deliberative democracy and Chinese deliberative practice, adding to our knowledge of local participatory institutions in local China, contributing to a b ....Western Theory of Deliberative Democracy and Chinese Practice of Participatory and Deliberative Institutions. This project is aimed to study how various participatory and deliberative institutions are pursued and promoted by peasants and residents in local governance in China. It is the first study that builds a bridge between Western theory of deliberative democracy and Chinese deliberative practice, adding to our knowledge of local participatory institutions in local China, contributing to a better design of, and improvement of, these institutions, and developing lessons and policy implications that will be broadly applicable not only to most parts of China, but also to other developing countries and beyond.Read moreRead less
The coming of the dingo and its interaction with Indigenous Australians. This project will identify more precisely the time of the entry of dingoes into Australia and will investigate their impact on the lives of Indigenous Australians. Archaeological and anthropological evidence suggests that Indigenous people rapidly incorporated dingoes into their lives. Dingoes were used for a variety of purposes and were particularly valued as hunters by women, effectively increasing their access to meat. ....The coming of the dingo and its interaction with Indigenous Australians. This project will identify more precisely the time of the entry of dingoes into Australia and will investigate their impact on the lives of Indigenous Australians. Archaeological and anthropological evidence suggests that Indigenous people rapidly incorporated dingoes into their lives. Dingoes were used for a variety of purposes and were particularly valued as hunters by women, effectively increasing their access to meat. Impact would include a re-organisation of gender roles and an associated improvement in women's fecundity. By examining evidence for such changes, this project will significantly contribute to knowledge about implications of the arrival of a living technology in Australia and, more generally, the human/dog relationship.Read moreRead less