Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.
Hatchery production of rock lobster seedstock for aquaculture and enhancement with emphasis on ozonation of culture water to reduce disease. The strong and growing worldwide demand for a range of lobster products cannot be fulfilled by existing wild fisheries. Only the sustainable production of lobsters using hatchery seedstock will satisfy the needs of aquaculture and the possibility of enhancing and reseeding the fishery. Lobster aquaculture will provide a new high-value industry for coastal r ....Hatchery production of rock lobster seedstock for aquaculture and enhancement with emphasis on ozonation of culture water to reduce disease. The strong and growing worldwide demand for a range of lobster products cannot be fulfilled by existing wild fisheries. Only the sustainable production of lobsters using hatchery seedstock will satisfy the needs of aquaculture and the possibility of enhancing and reseeding the fishery. Lobster aquaculture will provide a new high-value industry for coastal rural Australia, especially in areas with existing fishing and aquaculture enterprises. This project will develop new technologies to address the challenging target of producing commercial quantities of juvenile lobsters for aquaculture and enhancement.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH180100002
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. Thes ....ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. These dynamic systems will help determine what goal to achieve and the most efficient plan to achieve it. This Hub is expected to contribute to higher farming efficiency, lower production costs and fewer disease risks, giving the Australian industry new business opportunities and an international competitive advantage.Read moreRead less
Self-assembled nanolayers of functionalised latexes as selective and adaptable nano-stationary phases in separation science. A new approach is proposed for the design and synthesis of functionalised ion-exchange stationary phases for analytical nano-separation methods. Desired charged functional groups are first affixed chemically onto nanometre sized latex particles and these particles are then self-assembled mechanically as monoloayer coatings onto a suitable supporting template such as fused ....Self-assembled nanolayers of functionalised latexes as selective and adaptable nano-stationary phases in separation science. A new approach is proposed for the design and synthesis of functionalised ion-exchange stationary phases for analytical nano-separation methods. Desired charged functional groups are first affixed chemically onto nanometre sized latex particles and these particles are then self-assembled mechanically as monoloayer coatings onto a suitable supporting template such as fused silica, monolithic silica or polymer beds, microfibres or microtubes, and channels in microchips. The resultant coated surface then acts as a highly efficient ion-exchange stationary phase which will be used in a wide range of separation technologies including ion chromatography, capillary electrophoresis, capillary electrochromatography and solid-phase microextraction.Read moreRead less
Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-ter ....Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-terrorism applications; environmental, clinical, and forensic analysis; energy generation and foods. The project will also lead to very significant new intellectual property having extremely high commercial potential worldwide, and thereby generates the promise of considerable direct financial returns to Australia.Read moreRead less
Integrated microfluidic device for the direct analysis of drugs and metabolites in biological fluids. Due to the way in which multiple processes are integrated in a micro Total Analysis System (µTAS), they offer substantial advantages over current technology, in terms of speed, cost of analysis, portability and operator simplicity and safety. This has considerable potential benefit for Australia, specifically for the remote and rural analysis of drugs and metabolites in biological fluids such a ....Integrated microfluidic device for the direct analysis of drugs and metabolites in biological fluids. Due to the way in which multiple processes are integrated in a micro Total Analysis System (µTAS), they offer substantial advantages over current technology, in terms of speed, cost of analysis, portability and operator simplicity and safety. This has considerable potential benefit for Australia, specifically for the remote and rural analysis of drugs and metabolites in biological fluids such as blood, serum, urine and saliva. These devices will have application for point-of-care testing in therapeutic drug monitoring, which will improve medical treatment and the patient's quality of life, as well as for on-site analysis in forensics for the rapid determination of illicit drugs and performance enhancing substances in our elite athletes.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
Synthesis, characterisation and evaluation of novel ion-exchange polymer monolithic stationary phases for separation science. This project will provide highly significant, fundamental advances in separation science by accelerating the design and development of new stationary phases and separation technologies suitable for the analysis of very complex samples. The project will lead to very significant new intellectual property having extremely high commercial potential worldwide, and therefore t ....Synthesis, characterisation and evaluation of novel ion-exchange polymer monolithic stationary phases for separation science. This project will provide highly significant, fundamental advances in separation science by accelerating the design and development of new stationary phases and separation technologies suitable for the analysis of very complex samples. The project will lead to very significant new intellectual property having extremely high commercial potential worldwide, and therefore the project has potential for considerable direct financial returns to Australia. The new technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-terrorism applications; environmental, clinical, and forensic analysis; energy generation and foods. Read moreRead less