The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Efficacy Of Prism Adaptation For Recovery Of Brain Function In Unilateral Spatial Neglect
Funder
National Health and Medical Research Council
Funding Amount
$531,690.00
Summary
Damage to the brain’s attention network causes profound impairments of visual and sensory perception. These deficits are frequently long-lasting, and are a major factor in preventing patients from regaining functional independence. This project will use a combination of behavioural and brain imaging techniques to determine whether a promising new treatment involving visual retraining can improve function and reduce perceptual impairments after unilateral brain lesions.
Discovery Early Career Researcher Award - Grant ID: DE180100433
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration ....Cortical layer specific functional imaging of the human brain. This project aims to record layer specific cortical activity in humans by leveraging ultra-high field magnetic resonance imaging. It expects to yield robust techniques for the general analysis of neuroimaging-based, layer-specific measurements. This project will progress the fields of cognitive neuroscience and neuroimaging as well as bring the field of neuroimaging closer to that of neurophysiology and thus facilitate collaboration among researchers.Read moreRead less
A Scalable Theory of Behavior Composition for Practical Engineering Models of Human Performance. Minimizing human error and maximizing human performance is a major design goal in safety critical systems. The development of methods for affordable human performance modeling has widespread applicability for evaluating user-system interfaces. The compositional method explored here has been shown to make accurate predictions reduce model development time by an order of magnitude. Large safety critica ....A Scalable Theory of Behavior Composition for Practical Engineering Models of Human Performance. Minimizing human error and maximizing human performance is a major design goal in safety critical systems. The development of methods for affordable human performance modeling has widespread applicability for evaluating user-system interfaces. The compositional method explored here has been shown to make accurate predictions reduce model development time by an order of magnitude. Large safety critical applications, such as military or air traffic control systems, would benefit greatly. The proposed work tests whether the compositional methods will scale to more complex domains. The work will be coordinated with Australian industry, academia, and government research efforts.Read moreRead less
Determinants and consequences of conscious visual awareness. Usually salient images can disappear from awareness without corresponding stimulus changes. This project is based on an innovative account linking such disappearances to a functional adaptation which facilitates vision in cluttered environments. Project completion will expand Australia's knowledge base, forge links between junior and senior Australian based investigators and provide excellent training opportunities. Publication of rese ....Determinants and consequences of conscious visual awareness. Usually salient images can disappear from awareness without corresponding stimulus changes. This project is based on an innovative account linking such disappearances to a functional adaptation which facilitates vision in cluttered environments. Project completion will expand Australia's knowledge base, forge links between junior and senior Australian based investigators and provide excellent training opportunities. Publication of research in top-ranking international journals will further promote Australian science abroad. Ultimately, this research will have implications for the design and implementation of artificial visual systems, which must overcome many of the same dilemmas faced by the human visual system in cluttered environments.Read moreRead less
Human Time Perception. Most human tasks require timing on a scale of tens to hundreds of milliseconds. We must judge time to produce and comprehend speech, to move about and interact with our dynamic environment, to determine causality and decode information from sensory receptors. However, the neural bases of time perception are largely unknown. This project will explore temporal phenomena to determine how and where durations, temporal order and coincidence are encoded in the human brain. Proje ....Human Time Perception. Most human tasks require timing on a scale of tens to hundreds of milliseconds. We must judge time to produce and comprehend speech, to move about and interact with our dynamic environment, to determine causality and decode information from sensory receptors. However, the neural bases of time perception are largely unknown. This project will explore temporal phenomena to determine how and where durations, temporal order and coincidence are encoded in the human brain. Project results will provide new insight into the mechanisms of time perception, with implications for disorders associated with impaired time perception, such as autism, dyslexia and schizophrenia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101159
Funder
Australian Research Council
Funding Amount
$420,556.00
Summary
Understanding the role of hemispheric communication in the human brain. A crucial question in cognitive neuroscience regards how humans integrate perceptual information to understand and interact with our environment. This project aims to identify neural processes that operate competitively and cooperatively within the left and right hemispheres to understand how the human brain integrates information for perception. This project expects to generate new insight into the nature of hemispheric com ....Understanding the role of hemispheric communication in the human brain. A crucial question in cognitive neuroscience regards how humans integrate perceptual information to understand and interact with our environment. This project aims to identify neural processes that operate competitively and cooperatively within the left and right hemispheres to understand how the human brain integrates information for perception. This project expects to generate new insight into the nature of hemispheric communication and perceptual decision making. This should provide significant benefits by understanding how the two brain hemispheres process different visual information yet communicate efficiently to allow seamless interface with the world.Read moreRead less
Why does time seem to drag and fly? This project aims to investigate varying perceptions about the passage of time. It is unclear if these variations reflect functional adaptations that allow fast information processing in the face of disaster or if such sensations are inferred after the events in question. Nor is it clear if such experiences are similar across individuals. The project aims to answer these questions, with long-term potential to inform artificial intelligence systems that rely on ....Why does time seem to drag and fly? This project aims to investigate varying perceptions about the passage of time. It is unclear if these variations reflect functional adaptations that allow fast information processing in the face of disaster or if such sensations are inferred after the events in question. Nor is it clear if such experiences are similar across individuals. The project aims to answer these questions, with long-term potential to inform artificial intelligence systems that rely on temporal sensitivity. The project also has potential to provide insights into conditions associated with impaired time perception-place roles.Read moreRead less
Insights from brain imaging to study the neural basis of cognition. This project aims to address a major challenge - the need for a better understanding of the basis for human cognition. Humans have a unique capacity for diverse, complex, thought and behaviour. To achieve this our brains need to rapidly and flexibly reconfigure, directing attention to different aspects of the world moment-to-moment as we think and act. The project will combine innovative analysis methods with state-of-the-art n ....Insights from brain imaging to study the neural basis of cognition. This project aims to address a major challenge - the need for a better understanding of the basis for human cognition. Humans have a unique capacity for diverse, complex, thought and behaviour. To achieve this our brains need to rapidly and flexibly reconfigure, directing attention to different aspects of the world moment-to-moment as we think and act. The project will combine innovative analysis methods with state-of-the-art neuroimaging and brain stimulation to understand how key brain regions drive this process. Insights from this project will link brain activation to behaviour, improve insights from brain imaging, and contribute a better understanding of the neural basis of cognition. Such insights can ultimately benefit the development of evidence based approaches to key areas of public concern such as health and education.Read moreRead less