Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Fine-grained Human Action Recognition with Deep Graph Neural Networks. This project aims to develop novel graph neural network based deep learning algorithms for fine-grained human action recognition. This project expects to bring human action analysis to the next level and to significantly advance the analysis of subtle yet complex human actions. Expected outcomes of this project include theoretical advances on graph representation based deep learning algorithms for spatial-temporal data, and e ....Fine-grained Human Action Recognition with Deep Graph Neural Networks. This project aims to develop novel graph neural network based deep learning algorithms for fine-grained human action recognition. This project expects to bring human action analysis to the next level and to significantly advance the analysis of subtle yet complex human actions. Expected outcomes of this project include theoretical advances on graph representation based deep learning algorithms for spatial-temporal data, and enabling techniques for more objective human action analysis in many domains such as sports and health. This should provide significant benefits to any application domain involving big and complex spatial-temporal data for finer analytics and better knowledge discovery.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Efficient structure search over large graphs. The project aims to develop advanced search technology to support large-scale graph applications. The success of the project not only brings a breakthrough in technology development but also provides training for high quality personnel in this important and growing area, and brings considerable economic and social benefits to Australia.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100131
Funder
Australian Research Council
Funding Amount
$645,000.00
Summary
The AustLit resource: supporting research in studies of Australian literary and narrative cultures. AustLit traces the history of Australia’s engagement with the art of story by creating an innovative web-based environment where all aspects of literary history can be explored, analysed and shared. The 2013 program will broaden AustLit’s information base in areas ranging from contemporary multi-lingual publishing to publishing in the colonial era.