Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100131
Funder
Australian Research Council
Funding Amount
$645,000.00
Summary
The AustLit resource: supporting research in studies of Australian literary and narrative cultures. AustLit traces the history of Australia’s engagement with the art of story by creating an innovative web-based environment where all aspects of literary history can be explored, analysed and shared. The 2013 program will broaden AustLit’s information base in areas ranging from contemporary multi-lingual publishing to publishing in the colonial era.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100049
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arriv ....Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arrive at their conclusions.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less