I am a molecular virologist researching the host response to hepatitis C virus (HCV) infection with the aim of understanding how the liver clears HCV infection. An understanding of this process will hopefully lead to novel antiviral strategies to combat not only HCV but a broad range of other viral infections.
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Understanding recidivism and repeat incarceration among young male offenders: a biographical and longitudinal approach. The research focuses on the group of offenders who, as a cohort, annually commit the most crime within Australia. The production of longitudinal qualitative data about individual experiences of secure care, release, and imprisonment, will provide a foundation for empirically driven policies and debates in the area of youth crime and incarceration for each state and territory. A ....Understanding recidivism and repeat incarceration among young male offenders: a biographical and longitudinal approach. The research focuses on the group of offenders who, as a cohort, annually commit the most crime within Australia. The production of longitudinal qualitative data about individual experiences of secure care, release, and imprisonment, will provide a foundation for empirically driven policies and debates in the area of youth crime and incarceration for each state and territory. Accordingly, the community will benefit through the generation of new possibilities for intervening in cycles of persistent offending and repeat custodial sentences. This has major social, cultural and economic implications. Read moreRead less
Near Infrared (IR) Laser Dyes for Latent Fingermark Detection. This project will enable Australian law enforcement agencies to recover latent fingerprints from difficult surfaces through the use of near infrared dyes. The project will allow the recovery of fingerprints from a scene which would otherwise be lost to an investigation. We will provide new fingerprint development techniques and imaging methods to law enforcement agencies, enhancing their ability to identify a perpetrator and thereb ....Near Infrared (IR) Laser Dyes for Latent Fingermark Detection. This project will enable Australian law enforcement agencies to recover latent fingerprints from difficult surfaces through the use of near infrared dyes. The project will allow the recovery of fingerprints from a scene which would otherwise be lost to an investigation. We will provide new fingerprint development techniques and imaging methods to law enforcement agencies, enhancing their ability to identify a perpetrator and thereby reducing crime rates.Read moreRead less
Suicide Terrorism: The Use of Life as a Weapon. Bali attacks were a powerful reminder that Australians are not immune from terrorism. Suicide terrorism is the most lethal form of terrorism. It constitutes 3 % of all terrorist attacks but accounts for 48 % of all deaths. Australia's involvement in Afghanistan, Iraq and East Timor has made Australia a more likely terrorist target. An informed understanding of suicide terrorism in our region would assist in developing appropriate policies for prote ....Suicide Terrorism: The Use of Life as a Weapon. Bali attacks were a powerful reminder that Australians are not immune from terrorism. Suicide terrorism is the most lethal form of terrorism. It constitutes 3 % of all terrorist attacks but accounts for 48 % of all deaths. Australia's involvement in Afghanistan, Iraq and East Timor has made Australia a more likely terrorist target. An informed understanding of suicide terrorism in our region would assist in developing appropriate policies for protecting Australia from terrorism. The research will also contribute to evaluation of costs and benefits of Australian government policies of democratisation in the region and War on Terror.Read moreRead less
Hepatitis C affects a quarter of a million Australians, causing insidious but progressive liver disease which culminates in liver failure or cancer. There is no vaccine and prevention programs have limited effectiveness, but new antiviral therapies now offer high rates of cure. This Program will evaluate strategies to improve the health of those affected and prevent new infections by better understanding of the virus and the body’s immune response, including scarring and liver cancer formation.
Interventions To Improve Outcomes For Young Aboriginal And Torres Strait Islander People In Sexually Transmissible Infections Blood Borne Viruses And For People Using Methamphetamines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This ECF will enable research to be carried out in the domains of sexually transmissible infections (STI) and blood borne viruses (BBV) and specifically methamphetamine (MA) use in Aboriginal communities nationally. Specific research outcomes will be the establishment of an Aboriginal primary health care and behavioural surveillance network for STIs/BBVs in nationally dispersed clinical hubs (CRE), and an improved understanding of interventions to address MA in Aboriginal communities.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Understanding and Managing the Occupational Health Impacts on Investigators of Internet Child Exploitation. Through developing best practice models for managing vicarious trauma in investigators of Internet child exploitation, the project will result in enhanced job satisfaction and less burnout of workers, and reduced health costs for policing organisations. Thus the project addresses a serious occupational health issue and contributes to the goal of promoting and maintaining good health. Furth ....Understanding and Managing the Occupational Health Impacts on Investigators of Internet Child Exploitation. Through developing best practice models for managing vicarious trauma in investigators of Internet child exploitation, the project will result in enhanced job satisfaction and less burnout of workers, and reduced health costs for policing organisations. Thus the project addresses a serious occupational health issue and contributes to the goal of promoting and maintaining good health. Further, by better managing the occupational health of investigators, the project will enhance the capacity of police organisations to deliver on their mission of investigating and preventing Internet child exploitation. This in turn contributes to the reduced consumption of Internet child exploitation and the associated traumatisation of abused victims. Read moreRead less