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We have entered an era where it is now possible to sequence an individual's genetic blueprint. In the case of cancer this can be used to determine the genetic damage that has occurred in cancer cells. This fellowship seeks to carry out large scale sequencing of cancer patient and map out the genetic damage that is common to get a handle on what drives the disease. It will also investigate how personalized mutation detection might improve cancer treatment selection for individual patients.
I am a virologist working on hepatitis C virus with projects to investigate antiviral agents, vaccine technology, aspects of HCV immunity and treatment by immunotherapy.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Nuclear Transport In Health And Disease; Towards Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
This research fellowship will enable new therapeutic approaches to viral disease and cancer that target the transport process. I have already licenced an inhibitory molecule for Dengue virus which is progressing towards the clinic. I will now extend my research into a vibrant translational program of developing anti-viral (HIV, Respiratory Syncytical Virus, VEEV) as well as anti-cancer agents that will represent realistic therapeutic options in the near future.
Defining Genomic Mechanisms Associated With Treatment Response, Drug Resistance And Early Blast Crisis In Chronic Myeloid Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Chronic myeloid leukaemia is a fatal disease if untreated. Most patients now survive with new drugs, but some still rapidly die. I aim to understand these differences by investigating the genetic makeup of patients at diagnosis. Some may have gene mutations that prevent drugs from working effectively. Mutations will be detected using technology that can search more than 30,000 genes at the same time. This work could lead to improved survival for more patients by finding new targets for therapy.
I am a biochemical geneticist working on inherited disorders that affect the musculoskeletal system. My major focus is determining the molecular basis of muscular dystrophies and bone and cartilage disorders.
This project involves a unique interdisciplinary approach combining bioinformatics, biostatistics and mathematical biology to better understand the dynamics of infection and immunity. Using data from in vitro studies, animal models, and human infections, I aim to understand immune control and pathogen growth and evolution in HIV and malaria infection.
Enhancing Disease Vector Biosecurity Through High Density Molecular Markers
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
The outbreak of several diseases spread by mosquitoes is increasing rapidly around the world, driven by increased people movement spreading both viruses and disease vectors, a lack of effective vaccines and changing climatic conditions. In this proposal I aim to develop cutting edge molecular tools for identifying pathways of exotic mosquito introductions into Australia and a program that uses bacteria living inside mosquitoes in novel ways for disease suppression.
This fellowship is to support Professor Stephen Kent in generating new advances in vaccines to prevent HIV (the cause of AIDS) and Influenza (“The Flu”). HIV causes over 1.5 million deaths per year and no vaccine is currently available. Influenza causes around half a million deaths per year. Although the current Influenza vaccine is partially effective, improvements are needed for it to be able to protect against the many different strains of Influenza that can cause infection.