Why do good males die young? The relationship between ageing and sexual selection. A biological understanding of ageing is directly relevant to human welfare. We will use lab and field studies to explore the evolutionary genetics of ageing in an Australian cricket, with particular emphasis on how diet and the timing of reproduction influence the rate at which crickets deteriorate with age. We will also test whether biological differences between males and females generate genetic conflicts over ....Why do good males die young? The relationship between ageing and sexual selection. A biological understanding of ageing is directly relevant to human welfare. We will use lab and field studies to explore the evolutionary genetics of ageing in an Australian cricket, with particular emphasis on how diet and the timing of reproduction influence the rate at which crickets deteriorate with age. We will also test whether biological differences between males and females generate genetic conflicts over ageing rates. Our results will not only complement an evolutionary study of ageing, but may ultimately suggest interventions that may prolong human life or improve the quality of life in an ageing population.Read moreRead less
Linking the evolutionary and bioenergetic causes of sex differences in lifespan and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how genes, hormones, tissues and cells interact during ageing. Interventions to prolong longevity and improve quality of life depend on a vigorous and innovative research effort in both spheres. This project addresses why males and females have differe ....Linking the evolutionary and bioenergetic causes of sex differences in lifespan and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how genes, hormones, tissues and cells interact during ageing. Interventions to prolong longevity and improve quality of life depend on a vigorous and innovative research effort in both spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Because of the human interest in diet, sex, reproduction and ageing, we expect this research will be a showcase for public interest in science.Read moreRead less
The role of sexual conflict in the evolution of lifespan and ageing. Despite the central importance of ageing in our own lives, our understanding of the evolution of ageing is still incomplete. Reproductive interests of males and females often diverge, resulting in sexual conflict which may in turn drive the evolution of rapid ageing. I will use experimental evolution to investigate the role of sexual conflict in the evolution of age-specific mortality, reproductive ageing and lifespan in the se ....The role of sexual conflict in the evolution of lifespan and ageing. Despite the central importance of ageing in our own lives, our understanding of the evolution of ageing is still incomplete. Reproductive interests of males and females often diverge, resulting in sexual conflict which may in turn drive the evolution of rapid ageing. I will use experimental evolution to investigate the role of sexual conflict in the evolution of age-specific mortality, reproductive ageing and lifespan in the seed beetle Callosobruchus maculates. This study will reveal the role of sexual interactions and reproduction in the ageing process and result in the development of important new resources for resolving the genetic basis of deteriorative ageing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100836
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Oxidative stress as a physiological constraint on the pace of life histories. The project will draw on several areas of biology to answer a fundamental question: which mechanisms underlie the link between vital processes, like growth and reproduction, and rates of biological ageing? This research is needed to understand the basis of trade-offs that cause some individuals or species to age faster than others.
Combining evolutionary, physiological and molecular approaches to understand ageing and performance. How organisms grow, behave and perform is a result of environmentally triggered molecular, physiological and biochemical reactions. Little is known about how these different levels of organisation interact to create the infinite morphological and behavioural complexities seen in adults. This project aims to integrate the fields of developmental, physiological and evolutionary biology to elucidate ....Combining evolutionary, physiological and molecular approaches to understand ageing and performance. How organisms grow, behave and perform is a result of environmentally triggered molecular, physiological and biochemical reactions. Little is known about how these different levels of organisation interact to create the infinite morphological and behavioural complexities seen in adults. This project aims to integrate the fields of developmental, physiological and evolutionary biology to elucidate how the environment moderates cell and tissue development through gene expression. This will highlight how early developmental decisions affect lifetime energetic trade-offs and efficiency, and how underlying biology manifests into emergent phenomena such as performance, behaviour, ageing and lifespan.Read moreRead less
Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evol ....Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Read moreRead less
Biodiversity and population genetics of groundwater calcrete ecosystems of central Western Australia. This project will lead to documentation of a unique subterranean ecosystem of world acclaim, representing a significant component of the biodiversity of the Australian arid zone. It will further contribute to sustainable management of groundwater ecosystems and provide information that can be used to predict and monitor how future water use and climate change may impact on these ecosystems. Resu ....Biodiversity and population genetics of groundwater calcrete ecosystems of central Western Australia. This project will lead to documentation of a unique subterranean ecosystem of world acclaim, representing a significant component of the biodiversity of the Australian arid zone. It will further contribute to sustainable management of groundwater ecosystems and provide information that can be used to predict and monitor how future water use and climate change may impact on these ecosystems. Results generated will provide the knowledge base required to improve the efficiency and scientific rigour of the environmental review process for major resource projects, leading to economic benefits to the mining and environmental consultancy industries, and to Australia in general.Read moreRead less
Assessment of the diversity, distribution and uniqueness of subterranean animals from calcrete aquifers in central western Australia. Recently a rich and diverse subterranean invertebrate fauna (stygofauna) was unexpectedly discovered from numerous isolated calcrete aquifers associated with palaeodrainage channels in central Western Australia. Our recent taxonomic and molecular studies have suggested that stygofaunas within each aquifer may be highly endemic. We aim to test this hypothesis by in ....Assessment of the diversity, distribution and uniqueness of subterranean animals from calcrete aquifers in central western Australia. Recently a rich and diverse subterranean invertebrate fauna (stygofauna) was unexpectedly discovered from numerous isolated calcrete aquifers associated with palaeodrainage channels in central Western Australia. Our recent taxonomic and molecular studies have suggested that stygofaunas within each aquifer may be highly endemic. We aim to test this hypothesis by investigating the diversity, distribution and uniqueness of stygofauna from three major calcrete regions. We further aim to document the environmental conditions and variability within the aquifers and to develop rigorous sampling protocols. Such data are essential for the development of appropriate strategies for sustainable management of subterranean water and their ecosystems.Read moreRead less
Environmental stress profiling (ESP): Molecular profiling of sediment microbial communities for improved biological monitoring in aquatic ecosystems. Water resource management is a key issue for environmental sustainability in Australia and strategies that include ecological principles are important to improve present conditions and reduce further degradation. Current biomonitoring methods suffer from a low degree of sensitivity that can seriously impact their effectiveness as early warning sign ....Environmental stress profiling (ESP): Molecular profiling of sediment microbial communities for improved biological monitoring in aquatic ecosystems. Water resource management is a key issue for environmental sustainability in Australia and strategies that include ecological principles are important to improve present conditions and reduce further degradation. Current biomonitoring methods suffer from a low degree of sensitivity that can seriously impact their effectiveness as early warning signals of ecological disturbance. We propose to combine molecular and ecotoxicological assessment of the effect of zinc toxicity on microbial communities to provide rapid pollution sensitive bioassessment. Our research will lead to a better understanding of the cause and effect of heavy metal pollution within aquatic ecosystems and greater insight on how to reduce and repair the negative effects.Read moreRead less