Understanding Novel Viral Host Interactions That Modulate Innate Immunity
Funder
National Health and Medical Research Council
Funding Amount
$764,246.00
Summary
Lethal viruses such as coronaviruses (MERS, SARS-CoV-1, SARS-CoV-2), Dengue, Zika, Hendra, and Nipah have developed effective mechanisms of replication by dampening the host immune system. Here we will examine how viruses carry out these immune evasion functions, and test antiviral drugs that can prevent these effects in a highly specific manner. If this idea can be proved, it will provide great promise for the development of new antivirals whilst minimising the toxic effects to the cell.
Targeting MiRNA Biogenesis To Treat Herpes Simplex Virus Latency
Funder
National Health and Medical Research Council
Funding Amount
$800,085.00
Summary
Herpes simplex virus (HSV) causes cold sores in most infected people, but can also cause blindness and fatal brain infections. The biggest problem with HSV is that it never completely goes away - the virus hides in a part of the nervous system and can come out to cause disease over and over again. We have recently discovered a gene in people that the virus needs to maintain itself in this hidden state. In this project we will use this exciting discovery to work towards a cure for HSV.