Deadly Liver Mob: Engaging Aboriginal People In Viral Hepatitis, HIV And Sexual Health Services
Funder
National Health and Medical Research Council
Funding Amount
$848,441.00
Summary
Rates of blood-borne viruses and sexually transmissible infections are high among the Aboriginal and Torres Strait Islander population. A local initiative in western Sydney has trialed a new approach to engagement and care of Aboriginal people. We will implement this approach in services across NSW and evaluate its effectiveness as a sustainable and acceptable model for engaging Aboriginal people in care and develop an implementation plan for future roll-out to other services.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
The Genetic Basis of Differences Between the Sexes. Improved medical interventions against genetic disorders like cancer are made possible by advances in fundamental understanding of gene function and, especially, genetic mechanisms (like genomic imprinting) that are directly implicated in these disorders. Furthermore, an understanding of environmental effects within and across generations is vital in an age of global climate change. Recent theory and evidence suggest that research on sexually d ....The Genetic Basis of Differences Between the Sexes. Improved medical interventions against genetic disorders like cancer are made possible by advances in fundamental understanding of gene function and, especially, genetic mechanisms (like genomic imprinting) that are directly implicated in these disorders. Furthermore, an understanding of environmental effects within and across generations is vital in an age of global climate change. Recent theory and evidence suggest that research on sexually dimorphic traits may hold a key to a better understanding of these phenomena. The proposed research will strengthen Australia's position as leader in evolutionary genetics, enhance knowledge of native fauna, and improve our understanding of biological phenomena that affect human health. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100755
Funder
Australian Research Council
Funding Amount
$371,000.00
Summary
Evolution of genome architecture. The project aims to understand how changes to genome architecture over evolutionary time are linked to the diversity of animal morphology. Our genome sequence is arranged into higher order structures that enable coordinated gene expression. The appropriate expression of genes in time and space is necessary to produce the multitude of cell types that make up a multicellular organism. Yet, to date, genome topology is poorly explored, especially between species. Th ....Evolution of genome architecture. The project aims to understand how changes to genome architecture over evolutionary time are linked to the diversity of animal morphology. Our genome sequence is arranged into higher order structures that enable coordinated gene expression. The appropriate expression of genes in time and space is necessary to produce the multitude of cell types that make up a multicellular organism. Yet, to date, genome topology is poorly explored, especially between species. The project involves comparisons of the 3D structure of genomes in divergent species. These findings are expected to inform the underlying principles of gene regulation in animals and species evolution.Read moreRead less
Disperse or die: the evolution of dispersal ability in a changing climate. Whether or not climate change will affect a species depends upon the ability of ecological communities to track climate change. Species that rapidly shift their range in response to climate change will not be unduly affected, whereas species that are stuck in one place are at extreme risk from a changing climate (they must either adapt, or perish). We need, therefore, a firm understanding of how, and how rapidly, specie ....Disperse or die: the evolution of dispersal ability in a changing climate. Whether or not climate change will affect a species depends upon the ability of ecological communities to track climate change. Species that rapidly shift their range in response to climate change will not be unduly affected, whereas species that are stuck in one place are at extreme risk from a changing climate (they must either adapt, or perish). We need, therefore, a firm understanding of how, and how rapidly, species shift their range. This project will develop a universal framework within which to model species' responses to climate change. As such, the project will contribute greatly to how we plan for, and manage, the effects of climate change.Read moreRead less
The role of RNA editing by the brain-specific enzym ADAR3 in learning and memory. Higher-order cognition sets us apart from other species but how this is achieved is still under debate. The project will test the idea, strongly supported by recent genomic analyses, that subtle changes in the sequences of RNA in response to environmental stimuli underpin this extraordinary ability.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100161
Funder
Australian Research Council
Funding Amount
$540,000.00
Summary
A multi-omics platform for molecular evolution and developmental biology. A multi-omics platform for molecular evolution and developmental biology: The proposed multi-omics platform will provide the computational environment (consisting of data, computer hardware, software and workflows) required to undertake large scale 'omics based research projects within molecular evolution and developmental biology. The platform architecture is designed to accommodate the requirements of data intensive rese ....A multi-omics platform for molecular evolution and developmental biology. A multi-omics platform for molecular evolution and developmental biology: The proposed multi-omics platform will provide the computational environment (consisting of data, computer hardware, software and workflows) required to undertake large scale 'omics based research projects within molecular evolution and developmental biology. The platform architecture is designed to accommodate the requirements of data intensive research in a collaborative environment where datasets, tools and workflows can be shared. Bringing together complementary expertise in molecular evolution and developmental biology, the platform will provide the opportunity to perform integrative analysis across genomes, transcriptomes, proteomes, metabalomes and epigenomes, providing a unique collaborative analytical platform for Australian researchers.Read moreRead less
The big flood: will it happen again? If we could better predict the frequency of extreme flood events, would we be better prepared to safeguard human lives and settlements? This project provides a time-line of flood activity in the south east Queensland region extending back thousands of years using state-of-the-art dating techniques and seeks to identifiy those settlements most at risk.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less