Nanoparticle radiosensitisation. This project aims to develop new knowledge through a better understanding of physics interactions of particles in compounds with sub-micron size. Research on radiosensitisation by sub-micrometre sized nanoparticles (NPs) is hot worldwide because it could treat cancer, but the physical/physico-chemical/biological mechanism of radiosensitisation is unclear because no physical models describe particle interactions at nanometre scale in solid state nanometre sized ob ....Nanoparticle radiosensitisation. This project aims to develop new knowledge through a better understanding of physics interactions of particles in compounds with sub-micron size. Research on radiosensitisation by sub-micrometre sized nanoparticles (NPs) is hot worldwide because it could treat cancer, but the physical/physico-chemical/biological mechanism of radiosensitisation is unclear because no physical models describe particle interactions at nanometre scale in solid state nanometre sized objects. This project will develop and evaluate specialised physics models to describe particle interactions in NPs and help optimise nanoparticle technology. It will develop expertise in Australia in physics modelling for nanomedicine and other applications of nanotechnology exposed to radiation (e.g. telecommunications, aviation and space).Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100008
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Australian Seismic Imaging Array. The project aims to create a facility for developing techniques for imaging the deep earth and the surface motion in ambient seismic waves created by wind, waves and human activity. The techniques will enable sources of seismic vibrations to be identified and suppressed, and will allow mapping techniques to be developed for monitoring and discovery of resources such as ground water. Gravitational wave researchers will benefit from the ability to suppress seismic ....Australian Seismic Imaging Array. The project aims to create a facility for developing techniques for imaging the deep earth and the surface motion in ambient seismic waves created by wind, waves and human activity. The techniques will enable sources of seismic vibrations to be identified and suppressed, and will allow mapping techniques to be developed for monitoring and discovery of resources such as ground water. Gravitational wave researchers will benefit from the ability to suppress seismic vibrations, while geophysicists will benefit from new techniques and training. Read moreRead less
Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance ....Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance tool with submillimetre spatial resolution. The proposed Australian radiation detection technology is expected to improve understanding of the scientific mechanisms underpinning the radiobiological effectiveness of heavy ion radiation.Read moreRead less
Detecting the deaths of the first stars: Investigating the physical processes in the early Universe. This project will pursue the most distant supernova explosions in the Universe and investigate their host galaxies and environments. It will use a technique that has detected the most distant supernovae, probing 12 billion years into the past, and one that is able to discover, for the first time, the deaths of the first stars to have formed after the Big Bang. This project will use this technique ....Detecting the deaths of the first stars: Investigating the physical processes in the early Universe. This project will pursue the most distant supernova explosions in the Universe and investigate their host galaxies and environments. It will use a technique that has detected the most distant supernovae, probing 12 billion years into the past, and one that is able to discover, for the first time, the deaths of the first stars to have formed after the Big Bang. This project will use this technique to gather a statistical sample of supernovae to determine their occurrence rate and physical properties and to provide crucial data for a newly discovered, extremely powerful, third type of supernova. This data will test the laws in which early galaxies formed their stars and reveal the framework for the subsequent evolution of the Universe.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100888
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Illuminating drug activity in the brain with nanocrystalline beacons. The project focuses on developing technologies to understand the activity of drugs and precisely locate their target sites in the brain. Novel nanocrystalline beacons and ultrahigh-sensitivity optical imaging technology developed in the project have the aim to help visualise opioid and other related drug molecules over extended periods, which is impossible with current methods. Quantifying drug target distribution in the brain ....Illuminating drug activity in the brain with nanocrystalline beacons. The project focuses on developing technologies to understand the activity of drugs and precisely locate their target sites in the brain. Novel nanocrystalline beacons and ultrahigh-sensitivity optical imaging technology developed in the project have the aim to help visualise opioid and other related drug molecules over extended periods, which is impossible with current methods. Quantifying drug target distribution in the brain and imaging their dynamics on a single molecule level will shed light on drug-target interactions.Read moreRead less
Space science and astronomy: New eyes on old stars: Decoding late-stage stellar evolution. Planetary nebulae, the extended shrouds of dying stars, are a fascinating, brief period in the life of most stars. Our Sun will eventually go through this phase engulfing the earth. Planetary nebulae are unique celestial laboratories thanks to their rich emission line spectra. They are amongst the most beautiful and mysterious of objects, whose startling images act as a photogenic magnet for public interes ....Space science and astronomy: New eyes on old stars: Decoding late-stage stellar evolution. Planetary nebulae, the extended shrouds of dying stars, are a fascinating, brief period in the life of most stars. Our Sun will eventually go through this phase engulfing the earth. Planetary nebulae are unique celestial laboratories thanks to their rich emission line spectra. They are amongst the most beautiful and mysterious of objects, whose startling images act as a photogenic magnet for public interest. Behind their beauty hides the mystery of how stars return carbon, one of life's essential building blocks - to interstellar space. This project will constitute the next major breakthrough in understanding these processes and addresses several significant astrophysical problems in the field via unique Australian data and instrumentation.Read moreRead less
Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microflui ....Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microfluidics to create an optofluidic method of particle separation. The proposed device could sort nanodiamonds more than a billion times faster than active sorting techniques. This is expected to lead to better tools for bio-imaging and bio-manipulation.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
Development of ozone-induced dissociation for lipidomics workflows. An Australian invention (ozone induced dissociation) will be developed in collaboration with a major instrument manufacturer. This project will provide Australian researchers with unique capabilities to investigate the role of lipids (fats) in human disease and will place them at the forefront of lipid research internationally.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100004
Funder
Australian Research Council
Funding Amount
$502,453.00
Summary
Semiconductor laser for adaptive optics in astronomy and space awareness. This project aims to create a laser system for use as a laser guide star. Semiconductor laser technology is a cost effective, highly reliable and compact alternative to expensive, inefficient, bulky laser systems. This laser has wide scientific appeal for research with telescopes in astronomy, and for satellite tracking and mitigation of the threat of space debris. Producing a sodium laser guide star in Australia is expect ....Semiconductor laser for adaptive optics in astronomy and space awareness. This project aims to create a laser system for use as a laser guide star. Semiconductor laser technology is a cost effective, highly reliable and compact alternative to expensive, inefficient, bulky laser systems. This laser has wide scientific appeal for research with telescopes in astronomy, and for satellite tracking and mitigation of the threat of space debris. Producing a sodium laser guide star in Australia is expected to secure the country's position as the premier provider of commercial-grade laser guide star adaptive optics systems for civil and defence telescopes around the world.Read moreRead less