Salmonella in poultry: improving vaccine efficacy . The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contaminatio ....Salmonella in poultry: improving vaccine efficacy . The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contamination of the food supply chain, and reduce the number of human salmonellosis cases.Read moreRead less
A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent ....A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent enteric parasite identified globally in dogs. Infection rates can be as high as 75% in puppies. Current treatments are failing due to poor efficacy, resistance and poor adherence to treatment schedules. We have identified a novel, extremely rapid acting series of compounds capable of single shot eradication of Giardia.Read moreRead less
Striving for the path of least herbicide resistance. This project aims to investigate novel strategies to mitigate the rise in herbicide resistance threatening Australian agricultural production and exports. The project expects to pioneer long-term strategies for the development of herbicides that “resist” resistance generation in weeds to prolong their effectiveness. Expected outcomes include advances in the development of single- and multi-target herbicidal compounds with new modes of action, ....Striving for the path of least herbicide resistance. This project aims to investigate novel strategies to mitigate the rise in herbicide resistance threatening Australian agricultural production and exports. The project expects to pioneer long-term strategies for the development of herbicides that “resist” resistance generation in weeds to prolong their effectiveness. Expected outcomes include advances in the development of single- and multi-target herbicidal compounds with new modes of action, and validation of their potential to yield synergistic combinations and delay the evolution of resistance. This should lay the foundations for significant long-term benefits to farmers and consumers, both in Australia and globally, including increased crop yields and improved food security.Read moreRead less
Regulation of autophagy dependent cell and tissue deletion. This project aims to elucidate novel mechanisms that regulate autophagy-depdendent cell death during animal development. It will combine the power of Drosophila genetics with multidisciplinary approaches, such as proteomics, bioinformatics and cell biology. Given the conserved nature of autophagy the oucomes will provide highly topical and exciting new knowledge of broad biological significance. The project will help establishing inter ....Regulation of autophagy dependent cell and tissue deletion. This project aims to elucidate novel mechanisms that regulate autophagy-depdendent cell death during animal development. It will combine the power of Drosophila genetics with multidisciplinary approaches, such as proteomics, bioinformatics and cell biology. Given the conserved nature of autophagy the oucomes will provide highly topical and exciting new knowledge of broad biological significance. The project will help establishing international collaborations, enhancing Australia’s competitiveness and reputation in an important area of research, and provide training of HDR students in skills across a range of areas. In the long-term the research findings may translate into improved agriculture, food production and human health outcomes.Read moreRead less
Maximising the value of Australia’s sheepmeat industry with smart photonics. This project aims to investigate new photonics technologies to measure meat quality in lamb and mutton. It expects to develop new knowledge in the areas of fibre optics and 3D printing for use by the red meat and livestock industries. Expected outcomes of this project include development of a new technology to rapidly identify premium meat during meat processing. This should provide significant benefits for Australia’s ....Maximising the value of Australia’s sheepmeat industry with smart photonics. This project aims to investigate new photonics technologies to measure meat quality in lamb and mutton. It expects to develop new knowledge in the areas of fibre optics and 3D printing for use by the red meat and livestock industries. Expected outcomes of this project include development of a new technology to rapidly identify premium meat during meat processing. This should provide significant benefits for Australia’s red meat industry, helping to establish Australia as a leading supplier of high-quality meat to domestic and international markets.Read moreRead less
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100908
Funder
Australian Research Council
Funding Amount
$461,815.00
Summary
Maximising the beneficial impacts of mycorrhizal fungi on grain nutrition. This project aims to determine the effects of beneficial soil fungi on wheat and rice grain quality for human nutrition using an innovative combination of physiological, molecular and agronomic techniques. The project expects to generate fundamental knowledge in sustainable agriculture, to improve grain quality and value. Expected outcomes of this project include enhanced understanding of the mechanisms underlying improve ....Maximising the beneficial impacts of mycorrhizal fungi on grain nutrition. This project aims to determine the effects of beneficial soil fungi on wheat and rice grain quality for human nutrition using an innovative combination of physiological, molecular and agronomic techniques. The project expects to generate fundamental knowledge in sustainable agriculture, to improve grain quality and value. Expected outcomes of this project include enhanced understanding of the mechanisms underlying improved grain quality, and the capacity to use soil fungi to increase grain micronutrient concentrations and bioavailability. This should provide significant environmental and societal benefits, such as promotion of the sustainable use of agricultural soils and more nutritious grain products for human consumption.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100163
Funder
Australian Research Council
Funding Amount
$860,365.00
Summary
Structure Determination Pipeline Capabilities for South Australia. This project aims to complete a high-throughput, automated pipeline for biomolecule crystallisation and provide enhanced X-ray structure determination capabilities for all sample types. This is critical because X-ray crystallography remains the primary technique for achieving molecular level insights to help solve cutting-edge problems in life, materials, chemical, earth and agricultural sciences. The diverse researcher community ....Structure Determination Pipeline Capabilities for South Australia. This project aims to complete a high-throughput, automated pipeline for biomolecule crystallisation and provide enhanced X-ray structure determination capabilities for all sample types. This is critical because X-ray crystallography remains the primary technique for achieving molecular level insights to help solve cutting-edge problems in life, materials, chemical, earth and agricultural sciences. The diverse researcher community in South Australia will benefit from a more rapid structure determination pipeline from molecular sample to structure. The infrastructure will drive research findings in energy and resources, food, soil and water security, advanced manufacturing and life sciences and lead to economic and technological impacts.Read moreRead less
Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understandin ....Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understanding of mammalian reproduction. The knowledge gained will have application in captive breeding and conservation of these extraordinary Australian mammals. The project also provides opportunity to train research students in cutting edge molecular biology and informatics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100135
Funder
Australian Research Council
Funding Amount
$880,000.00
Summary
An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for ....An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for structure determination from complex biological samples, particularly for closely related (isomeric) components. Servicing a diverse research community, this will enable new molecular insights to better understand the natural world, and accelerate cutting edge biotechnology advances intersecting life and chemical sciences.Read moreRead less