Investigating a novel signalling pathway for crop improvement. This project will dissect a newly identified signalling pathway in plants that regulates plant water use and carbon gain. It will deploy multiple techniques, including novel biosensors, to understand the links between the metabolism of plants and their environmental responses. The project will build partnerships with scientists at leading international institutions for enhanced outcomes, including access to specialised equipment and ....Investigating a novel signalling pathway for crop improvement. This project will dissect a newly identified signalling pathway in plants that regulates plant water use and carbon gain. It will deploy multiple techniques, including novel biosensors, to understand the links between the metabolism of plants and their environmental responses. The project will build partnerships with scientists at leading international institutions for enhanced outcomes, including access to specialised equipment and upskilling of our scientists. The generation of barley with the latest gene editing techniques aims to produce a non-GM crop with the potential for enhanced root C sequestration, lower water use and improved yield, three key goals for agricultural sustainability in the face of a drying Australian climate.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Microbially induced calcium carbonate precipitation in different substrates. Carbonates in the form of limestone represent an important reservoir of carbon on earth. They are recorded in several natural geological formations as corals, stromatolites, beach rocks. Microbes play an important role in the formation as well as dissolution of carbonates during microbially induced calcium carbonate precipitation (MICP) reactions on different substrates in natural and built environments. Much of our kno ....Microbially induced calcium carbonate precipitation in different substrates. Carbonates in the form of limestone represent an important reservoir of carbon on earth. They are recorded in several natural geological formations as corals, stromatolites, beach rocks. Microbes play an important role in the formation as well as dissolution of carbonates during microbially induced calcium carbonate precipitation (MICP) reactions on different substrates in natural and built environments. Much of our knowledge on MICP is limited due to poor understanding of the reaction kinetics at a molecular level. This project will develop new methods to enable and advance the knowledge of MICP process with profound implications for understanding natural geological formations as well as widen the scope of current engineering applications.Read moreRead less
Investigation of recognition memory in behavioural, electrophysiological, and functional neuro-imaging domains using state-trace analysis. This project utilises a novel methodology to investigate human recognition memory across three separate domains - behavioural, electrophysiological and functional neuro-imaging. The aim is to determine how these three aspects of memory are related and if they can be united by a single theory.
Origin of jaws - the greatest unsolved mystery of early vertebrate evolution. The 2008 discovery of an unborn embryo in the 380 million-year-old "Mother Fish" from the famous Gogo fossil deposit in NW Australia has attracted a collaboration of Australian, American and Chinese scientists to a new international collaboration. The team will study spectacular new fossils from central Australia and southern China, the oldest known back-boned animals with jaws and a hard skeleton. Innovative 3D X-ray ....Origin of jaws - the greatest unsolved mystery of early vertebrate evolution. The 2008 discovery of an unborn embryo in the 380 million-year-old "Mother Fish" from the famous Gogo fossil deposit in NW Australia has attracted a collaboration of Australian, American and Chinese scientists to a new international collaboration. The team will study spectacular new fossils from central Australia and southern China, the oldest known back-boned animals with jaws and a hard skeleton. Innovative 3D X-ray computer tomography, and the Australian synchrotron, will be used to investigate ancient cells and preserved soft tissue structures, to search for evidence that copulation and internal fertilization, as in modern mammals, might have originated when jaws first evolved. Read moreRead less
A formal signal detection model of eyewitness identification. The project aims to aid in producing better procedures for the collection and assessment of eyewitness identification evidence. In a police line-up, a witness is asked to identify a perpetrator from a group of similar individuals. Applied research has focused on conditions that optimise witness performance but many of the conclusions from this research have been challenged on the basis that they use inappropriate measures of performan ....A formal signal detection model of eyewitness identification. The project aims to aid in producing better procedures for the collection and assessment of eyewitness identification evidence. In a police line-up, a witness is asked to identify a perpetrator from a group of similar individuals. Applied research has focused on conditions that optimise witness performance but many of the conclusions from this research have been challenged on the basis that they use inappropriate measures of performance. Recent work has highlighted the usefulness of analyses based on the theory of signal detection. However, the line-up task does not fit easily within standard signal detection paradigms as it combines two tasks; detection and identification. The project aims to understand how these components work in order to measure witness performance.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
Three-Mode interactions and optical springs in high power optical cavities. Gravitational waves are tiny vibrations of space and time which carry vast energy. They will allow the first direct observation of black holes. To make frequent detections this project will harness the force of intense laser light, and use this force to improve the sensitivity of gravitational wave detectors.
State-trace analysis: theory and application. A fundamental question for the science of psychology is: how can we identify the functional components of the human mind from observed behaviour and bodily states? This project explores this question through a new methodology called state-trace analysis and apply it to a basic cognitive ability - the capacity to learn to classify different objects.
Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology c ....Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology community, and potentially change the accepted story of oxygen homeostasis in the kidney. This will provide significant benefits, such as the provision of the foundational physiological science behind a determinant of kidney health and its flow-on impact to quality of life.Read moreRead less