Host-tumour interplay in Tasmanian devils with devil facial tumour disease: can immune cells be harnessed for therapy? Tasmanian devils only exist naturally in Tasmania and Devil Facial Tumour Disease, an infectious cancer, could cause the extinction of the Tasmanian devil. This project will determine if Devil Facial Tumour Disease reduces the effectiveness of the devil's immune system and test if activated immune cells can protect against this disease.
Does mother know best? Unifying proximate causation and ultimate explanation in mammalian sex allocation. The study of parental effects is a fundamental area in evolutionary ecology, but is characterised by poor integration of theory (ultimate causation) and physiology (proximate causation). This is true in sex allocation research that focuses almost exclusively on ultimate causation without integrating the physiological mechanisms for sex ratio adjustment. Using a combination of experiments and ....Does mother know best? Unifying proximate causation and ultimate explanation in mammalian sex allocation. The study of parental effects is a fundamental area in evolutionary ecology, but is characterised by poor integration of theory (ultimate causation) and physiology (proximate causation). This is true in sex allocation research that focuses almost exclusively on ultimate causation without integrating the physiological mechanisms for sex ratio adjustment. Using a combination of experiments and modelling, the project addresses this gap in understanding mammalian sex allocation, specifically: the lack of known mechanism; the connection between proximate mechanistic explanation and adaptive fitness explanations; and, knowledge on constraints. This project argues that one mechanism, pre-implantation glucose levels, links adaptive hypotheses with proximate causation. Read moreRead less
Immunisation to protect against transmissible cancers in Tasmanian devils. This project aims to identify the immune escape mechanisms that the transmissible cancers, Devil Facial Tumour Disease (DFTD) use to avoid being killed by the immune system. Since the discovery of the second transmissible cancer (DFT2) mystery surrounds whether the devils immune system can respond to this cancer, hence this project will investigate the immune response to DFT2. The final aims are to develop a vaccine with ....Immunisation to protect against transmissible cancers in Tasmanian devils. This project aims to identify the immune escape mechanisms that the transmissible cancers, Devil Facial Tumour Disease (DFTD) use to avoid being killed by the immune system. Since the discovery of the second transmissible cancer (DFT2) mystery surrounds whether the devils immune system can respond to this cancer, hence this project will investigate the immune response to DFT2. The final aims are to develop a vaccine with the potential to protect healthy devils and cure devils with DFTD.Read moreRead less
Taking advantage of rising CO2 to maximise ecosystem productivity. The rising atmospheric concentration of carbon dioxide provides an opportunity to increase ecosystem productivity, especially in agricultural systems. To what extent is highly uncertain, particularly when combined with changing temperature and precipitation. It has recently been demonstrated that seasonal water supply is the strongest controller of the productivity response to high carbon dioxide concentrations of grasslands. Th ....Taking advantage of rising CO2 to maximise ecosystem productivity. The rising atmospheric concentration of carbon dioxide provides an opportunity to increase ecosystem productivity, especially in agricultural systems. To what extent is highly uncertain, particularly when combined with changing temperature and precipitation. It has recently been demonstrated that seasonal water supply is the strongest controller of the productivity response to high carbon dioxide concentrations of grasslands. This project aims to elucidate the processes governing this response and develop simple models that could allow the conditions required to maximise the productivity benefit from rising carbon dioxide concentration to be calculated.Read moreRead less
Structure and Evolution of High Brightness Temperature Cores of Quasars and Galaxies. Interstellar scintillation, ISS, is a revolutionary new and powerful technique which we will use to study the highest brightness temperature cores of radio quasars with unprecedented angular resolution, and probe the interstellar medium of our Galaxy in a way not previously possible. The combination of scintillation and conventional VLBI allows imaging with light-month to light-year resolution across the known ....Structure and Evolution of High Brightness Temperature Cores of Quasars and Galaxies. Interstellar scintillation, ISS, is a revolutionary new and powerful technique which we will use to study the highest brightness temperature cores of radio quasars with unprecedented angular resolution, and probe the interstellar medium of our Galaxy in a way not previously possible. The combination of scintillation and conventional VLBI allows imaging with light-month to light-year resolution across the known Universe. Scintillation observations are challenging basic synchrotron physics by uncovering quasar cores with temperatures possibly as high as 10^15 K, and lifetimes many times longer than theory. The Ceduna and Hobart telescopes are cornerstones of our scintillation and VLBI proposals.
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Masers: high resolution probes of star formation. The largest stars in the Galaxy play a vital role in the formation of
the atoms which make life on Earth possible. The birth of these stars
is shrouded in gas and dust through which only radiowaves penetrate.
In this project we will make observations of interstellar masers from
the hydroxyl and methanol molecules and through mathematical modelling
of molecular excitation and radiative transfer probe the physical,
chemical and evolution ....Masers: high resolution probes of star formation. The largest stars in the Galaxy play a vital role in the formation of
the atoms which make life on Earth possible. The birth of these stars
is shrouded in gas and dust through which only radiowaves penetrate.
In this project we will make observations of interstellar masers from
the hydroxyl and methanol molecules and through mathematical modelling
of molecular excitation and radiative transfer probe the physical,
chemical and evolutionary status of the high-mass stars associated
with the masers.Read moreRead less
Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods fo ....Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods for solving these problems accurately, and will contribute to the next generation of research mathematicians in Australia. Read moreRead less
The Dark-side of the Milky Way. Astronomers have long sought to determine the 3-dimensional structure of our Galaxy, the Milky Way, with limited success owing to its immense size and obscuration by dust at optical wavelengths. We know more about structure of tens of thousands of other galaxies than we do about the structure of the Milky Way on the far-side of the Galactic Centre. This program will use Australian infrastructure to make the most accurate distance measurements to date of the far-si ....The Dark-side of the Milky Way. Astronomers have long sought to determine the 3-dimensional structure of our Galaxy, the Milky Way, with limited success owing to its immense size and obscuration by dust at optical wavelengths. We know more about structure of tens of thousands of other galaxies than we do about the structure of the Milky Way on the far-side of the Galactic Centre. This program will use Australian infrastructure to make the most accurate distance measurements to date of the far-side of the Milky Way visible from the Southern hemisphere, completing the 3-dimensional picture of our Galaxy. These results will be leveraged to yield accurate distances, providing fundamental information on the stellar masses, luminosities, and ages.Read moreRead less
Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model ....Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model of phylogenetic branching,
analyses of nucleic acid structure and content (spin chain models of
RNA binding and of DNA open reading frames), and insights into the
origin of the code itself (via numerical codon similarity measures).
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Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips ....Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips, that promise to revolutionize the data processing industry, from radar to cellular telephones to computer networks. The young scientists who are working on this project will go on to lead the commercial and industrial applications of this new technology.Read moreRead less