Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes ....Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes of the project will include the development of new technology for organic synthesis and forging novel approaches for chemical alkylation and cross-coupling reactions. This can contribute to making important compounds more efficiently, safely and cheaper to produce in the future.Read moreRead less
General relativistic light propagation effects: new insight into cosmic voids, dark matter, dark energy, and Einstein's theory of gravity. This project aims to be the first to develop new methods which will allow accurate study of light propagation effects. These methods remove the “noise” (light propagation effects) from observational data, resulting in unprecedented accuracy of the analyses and new insight into properties of dark energy. At the same time these methods use the “noise” as the ac ....General relativistic light propagation effects: new insight into cosmic voids, dark matter, dark energy, and Einstein's theory of gravity. This project aims to be the first to develop new methods which will allow accurate study of light propagation effects. These methods remove the “noise” (light propagation effects) from observational data, resulting in unprecedented accuracy of the analyses and new insight into properties of dark energy. At the same time these methods use the “noise” as the actual signal to measure properties of the Universe, especially the mass distribution inside cosmic voids (places in the Universe avoided by galaxies), which will solve the problem of dark matter distribution inside cosmic voids. The project aims to use light propagation effects to test Einstein's theory of gravity at cosmological scales.Read moreRead less
Environmental and behavioural approaches for parasite resistant aquaculture. In modern fish aquaculture, parasite infections threaten efficient production. Ecological problems also arise when fish farms amplify parasite populations and cause outbreaks in surrounding wild fish populations. Present control methods rarely integrate the behaviour of the host fish. This project aims to assess the behaviours of hosts and the mechanisms that lead to parasite outbreaks. It will develop behavioural appro ....Environmental and behavioural approaches for parasite resistant aquaculture. In modern fish aquaculture, parasite infections threaten efficient production. Ecological problems also arise when fish farms amplify parasite populations and cause outbreaks in surrounding wild fish populations. Present control methods rarely integrate the behaviour of the host fish. This project aims to assess the behaviours of hosts and the mechanisms that lead to parasite outbreaks. It will develop behavioural approaches that separate host and parasite, reduce infection, and altering host behaviour to improve the effectiveness of treatments and minimise their environmental impacts. This project aims to create novel methods to control parasites in ways that limit their ability to evolve resistance.Read moreRead less
Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling pe ....Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling people to closely match their pharmaceutical consumption with their individual requirements. The advance will have implications for all patients, particularly those in remote and rural Australian populations. The same technology is likely to find applications in environmental monitoring of emerging pharmaceutical pollutants. Read moreRead less
High performance chromatography based on nanostructured monolithic polymers. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pharmaceutical analysis and drug discovery; environmental, clinical, and ....High performance chromatography based on nanostructured monolithic polymers. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pharmaceutical analysis and drug discovery; environmental, clinical, and forensic analysis; energy generation and foods. The project will also lead to very significant new intellectual property having extremely high commercial potential worldwide, and thereby generates the promise of considerable direct financial returns to Australia.Read moreRead less
Systems modelling for synergistic ecological-climate dynamics. The project aims to improve forecasts of the response of biodiversity to future climate change and so improve on-ground conservation management. A systems modelling framework will be developed and tested against real-world data to integrate a wide variety of biological and geophysical inputs and so produce more realistic predictions.
The magnetisation of Earth’s lithosphere: a new view from space. Earth’s magnetic field is an invaluable resource for studying the structure and dynamics of our planet, yet the full nature of Earth's magnetisation remains poorly understood. This project will uncover the dominant sources of magnetisation close to Earth's surface using next-generation satellite data and recent theoretical advances. Expected outcomes include the development of innovative models of lithospheric magnetisation that wi ....The magnetisation of Earth’s lithosphere: a new view from space. Earth’s magnetic field is an invaluable resource for studying the structure and dynamics of our planet, yet the full nature of Earth's magnetisation remains poorly understood. This project will uncover the dominant sources of magnetisation close to Earth's surface using next-generation satellite data and recent theoretical advances. Expected outcomes include the development of innovative models of lithospheric magnetisation that will be used to gain crucial insights into the dynamic evolution of our planet's crust and uppermost mantle. The benefits of the project address both economic and environmental issues, unravelling the nature of structures that control both mineral systems and heat flow variations beneath the Antarctic ice sheet. Read moreRead less
Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This p ....Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This project is expected to increase understanding of brain function at the cellular and system levels, and advance Australia’s multidisciplinary research capacity in neuroscience, cognitive sciences and nanobiotechnology to ultimately treat neurological disorders.Read moreRead less
Interpreting biological sequence information: untangling hybridisation. Hybridisation is believed to be important during adaptive radiations where species rapidly colonise new niches and respond to new environments, e.g. in times of climate change. This project will create the statistical tools and software required for evolutionary biologists to understand how hybridisation has helped shape the Australian flora.
New Insights into the Origin and Evolution of Life on Earth. This project aims to provide new insights into the origin of life on Earth, life’s diversification through the Precambrian, and the co-evolution of life and early Earth environments. It will be discipline-leading in that it will take the study of early life to the sub-micrometre and hence sub-cellular level. This will facilitate new opportunities for identifying the types of life present during early Earth history, their metabolisms, c ....New Insights into the Origin and Evolution of Life on Earth. This project aims to provide new insights into the origin of life on Earth, life’s diversification through the Precambrian, and the co-evolution of life and early Earth environments. It will be discipline-leading in that it will take the study of early life to the sub-micrometre and hence sub-cellular level. This will facilitate new opportunities for identifying the types of life present during early Earth history, their metabolisms, cellular chemistry and interactions with their environment. This project aims to also provide new search engines and more robust assessment criteria for life on other planets, and help to resolve specific scientific controversies, for example, the validity of claims for cellular life from 3.5 billion-year-old rocks.Read moreRead less