Salmonella in poultry: improving vaccine efficacy . The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contaminatio ....Salmonella in poultry: improving vaccine efficacy . The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contamination of the food supply chain, and reduce the number of human salmonellosis cases.Read moreRead less
Superbugs and veterinary drugs: are multidrug-resistant zoonotic pathogens residing in Australian animals? Antibiotic resistance is a growing problem affecting human health that is now emerging in animals and veterinary hospitals. This project will integrate surveillance with novel treatments and preventatives to develop effective strategies to limit the impact of resistant bacteria to animal health and prevent transfer between humans and animals.
A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent ....A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent enteric parasite identified globally in dogs. Infection rates can be as high as 75% in puppies. Current treatments are failing due to poor efficacy, resistance and poor adherence to treatment schedules. We have identified a novel, extremely rapid acting series of compounds capable of single shot eradication of Giardia.Read moreRead less
Artificial intelligence algorithms to predict risk of injury in racehorses. This project will address the urgent need for predicting and preventing catastrophic and career limiting limb injuries and cardiac arrhythmias in racehorses due to over (or under) training. Using data from GPS and movement sensors integrated into saddlecloths, artificial intelligence algorithms will convert cumulative data on speed, gait, and stride characteristics during training, along with injury data, into a risk mat ....Artificial intelligence algorithms to predict risk of injury in racehorses. This project will address the urgent need for predicting and preventing catastrophic and career limiting limb injuries and cardiac arrhythmias in racehorses due to over (or under) training. Using data from GPS and movement sensors integrated into saddlecloths, artificial intelligence algorithms will convert cumulative data on speed, gait, and stride characteristics during training, along with injury data, into a risk matrix. Recorded heart rate and ECG data will also be analysed using artificial intelligence to detect early evidence of the development of cardiac arrhythmias. The system will improve racehorse welfare, providing a simple interface to warn trainers when risk of injury becomes high, in order to prevent catastrophic breakdown.Read moreRead less
How to make antibiotics in pig feed redundant, naturally. Antimicrobial resistance has become a major issue in human and veterinary medicine being partially caused by the use of in-feed antimicrobials in farm animals. This project aims to completely eliminate antimicrobials from piglet feeds. The key differential approach is based on helping the physiology of the animal rather than testing interventions against bacteria. The project will consist of developing a novel nutritional strategy of natu ....How to make antibiotics in pig feed redundant, naturally. Antimicrobial resistance has become a major issue in human and veterinary medicine being partially caused by the use of in-feed antimicrobials in farm animals. This project aims to completely eliminate antimicrobials from piglet feeds. The key differential approach is based on helping the physiology of the animal rather than testing interventions against bacteria. The project will consist of developing a novel nutritional strategy of naturally (through maternal conditioning) boosting the natural appetite and the capacity to digest in piglets early in life. The anticipated outcome is that the new peri-natal program will result in minimal bacterial proliferation and diarrhoea thus, negating the need for in-feed antimicrobials in piglets. Read moreRead less
Agave; a new Australian crop with a resilient spirit. This project aims to set the foundations to establish Agave as a sustainable, versatile and climate-proof Australian crop, supporting production of a new high value spirit for domestic and global markets. Outcomes will include novel cultivation and sensor technology for agave harvest at the "sweet spot" and advanced spirit assessment technologies allied with consumer sensory testing. Product character and consistency will be optimised by holi ....Agave; a new Australian crop with a resilient spirit. This project aims to set the foundations to establish Agave as a sustainable, versatile and climate-proof Australian crop, supporting production of a new high value spirit for domestic and global markets. Outcomes will include novel cultivation and sensor technology for agave harvest at the "sweet spot" and advanced spirit assessment technologies allied with consumer sensory testing. Product character and consistency will be optimised by holistic integration and control of the production chain, encompassing plant growth, input materials, and fermentation and distillation steps for a complete plant to bottle pipeline. Read moreRead less
Novel click assembled drug-polymer conjugates as next generation drug delivery systems. The purpose of the project is to develop previously inaccessible drug-polymer conjugates with tuneable and sustained drug release rates via a novel polymerisation approach. Ultimately, this will afford next-generation polymer therapeutics suitable for the treatment of a range of disorders and diseases, leading to improvements in heath care.
A low-cost water vapour profiler for the lower troposphere. Water vapour plays an important role in weather forecasting, as well as being the most important greenhouse gas. Its distribution is not known in sufficient detail for many aspects of predicting weather and climate change. With the Bureau of Meteorology we will develop a low-cost laser ranging system to measure the profile of water vapour in the lower atmosphere. A low-cost instrument can be placed at a sufficient number of locations ....A low-cost water vapour profiler for the lower troposphere. Water vapour plays an important role in weather forecasting, as well as being the most important greenhouse gas. Its distribution is not known in sufficient detail for many aspects of predicting weather and climate change. With the Bureau of Meteorology we will develop a low-cost laser ranging system to measure the profile of water vapour in the lower atmosphere. A low-cost instrument can be placed at a sufficient number of locations to significantly enhance weather forecasting and climate modelling. The instrument will be useful for detecting fog formation, measuring cloudbase heights and can be adapted for pollution detection and measurement.Read moreRead less
Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and indus ....Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and industry to join the search for dark matter. This Australian experiment aims to help to confirm or deny current results from Northern Hemisphere experiments. As the mine nears the end of its working life as a gold mine, this project is expected to benefit the local economy and provide opportunities for education and outreach.Read moreRead less
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less