Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These c ....Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These cells cannot divide and so when this store is exhausted, reproduction ceases. Our strategy is to develop pharmaceutical reagents that will destroy this dormant egg population, thereby rendering the animals instantaneously and irreversibly infertile.Read moreRead less
Enhancing the efficiency of equine reproduction: relevant to the Thoroughbred and Standardbred breeding industries. The purpose of this project is to link the equine breeding industry with a major centre of reproductive research at the University of Newcastle. By creating this unique nexus, major efficiency gains will be achieved for this industry that will not only secure its international competitiveness but also significantly enhance its profitability.
Discovery Early Career Researcher Award - Grant ID: DE180100894
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Molecular mechanisms of equine fertility and early recognition of pregnancy. This project aims to identify biomarkers of stallion fertility and early pregnancy in thoroughbred and Standardbred horses using biochemistry, proteomics and ribonucleic acid analyses. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project will connect Australian horse breeders and international clinical experts with the world renowned reproducti ....Molecular mechanisms of equine fertility and early recognition of pregnancy. This project aims to identify biomarkers of stallion fertility and early pregnancy in thoroughbred and Standardbred horses using biochemistry, proteomics and ribonucleic acid analyses. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project will connect Australian horse breeders and international clinical experts with the world renowned reproductive Priority Research Centre with the intended outcome of novel reproductive technologies and diagnostic tests. This should both secure international competitiveness and significantly enhance profitability and employment in this culturally significant industry.Read moreRead less
Use of quinone adducted peptides in the regulation of fertility. This project describes a novel strategy for the non-surgical induction of sterility in male and female mammals with applications in the fields of biotechnology, veterinary medicine and the humane control of pest animal species. The approach is dependent upon the known sensitivity of the germ line to oxidative stress. The strategy rests upon the demonstration that quinone-adducted peptides will selectively bind to non-renewable cel ....Use of quinone adducted peptides in the regulation of fertility. This project describes a novel strategy for the non-surgical induction of sterility in male and female mammals with applications in the fields of biotechnology, veterinary medicine and the humane control of pest animal species. The approach is dependent upon the known sensitivity of the germ line to oxidative stress. The strategy rests upon the demonstration that quinone-adducted peptides will selectively bind to non-renewable cell types in the ovary and testis and redox cycle at the cell surface generating a highly localised state of oxidative stress. This stress will then recapitulate the impact of radiation on reproductive tissues by selectively compromising the viability of the germ line, inducing a state of sterility.Read moreRead less