Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection follo ....Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection following a single administration. The aims of this study are to investigate the immunological mechanisms underlying the protective response by this novel vaccine using bovine and murine models. This study will discover new control measures for botulism in Australia.Read moreRead less
Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe t ....Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe that appears to have uniquely evolved in Australia. These results could inform the rational design of monitoring, prevention and treatment strategies to minimise infection outbreaks in Australian pigs and may result in production benefits to the pork industry, reduced environmental microbial contamination and safer food.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100020
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Collaborative high bio-containment immunological research facility. Emerging infectious diseases are a serious threat to animals and humans, with most new human infections originating in animals. Our capacity to study these infections and their effects on the immune system is limited. This Facility will provide core equipment for analysis of immune responses to infection at the highest levels of bio-containment.