Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less
Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dis ....Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.Read moreRead less
ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other cou ....ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other countries to develop new technologies for the detection and eradication of parasites. This emphasis will not only protect Australia's borders but will assist our near neighbours and lead to the development of technologies with an economic benefit to Australia.
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Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100008
Funder
Australian Research Council
Funding Amount
$4,459,672.00
Summary
ARC Training Centre for Innovative Wine Production. The ARC Training Centre for Innovative Wine Production aims to tackle challenges to wine production through innovative, multi-disciplinary research. Australia’s grape and wine industry is a multi-billion dollar industry, yet in some areas profitability is low. Reasons include extreme weather events, soil salinity and diseases, inefficient practices, a low level of technological innovation and high input costs. New technologies and process effic ....ARC Training Centre for Innovative Wine Production. The ARC Training Centre for Innovative Wine Production aims to tackle challenges to wine production through innovative, multi-disciplinary research. Australia’s grape and wine industry is a multi-billion dollar industry, yet in some areas profitability is low. Reasons include extreme weather events, soil salinity and diseases, inefficient practices, a low level of technological innovation and high input costs. New technologies and process efficiencies developed as part of this project will reduce environmental impact, drive production costs down and profits and employment up. The project will mount a suite of industry-led projects to deliver outcomes to boost Australia’s competitiveness as a supplier of sustainably-produced premium branded wine to the world.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100008
Funder
Australian Research Council
Funding Amount
$4,282,859.00
Summary
ARC Training Centre for Behavioural Insights for Technology Adoption (BITA). Australia needs accelerated adoption of innovation technologies to improve outcomes in health, agriculture and cybersecurity. Despite technically viable solutions, innovations fail to be adopted due to behavioural barriers. Behavioural approaches can promote significant gains by bridging the barriers to technology adoption. The Centre for Behavioural Insights for Technology Adoption will boost national productivity by i ....ARC Training Centre for Behavioural Insights for Technology Adoption (BITA). Australia needs accelerated adoption of innovation technologies to improve outcomes in health, agriculture and cybersecurity. Despite technically viable solutions, innovations fail to be adopted due to behavioural barriers. Behavioural approaches can promote significant gains by bridging the barriers to technology adoption. The Centre for Behavioural Insights for Technology Adoption will boost national productivity by identifying, designing and evaluating solutions that address these barriers. By uniting industry and government with world-leading interdisciplinary researchers, the Centre will build transformative capability in people, data and solutions and support Australian organisations to achieve higher returns on technology investment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100190
Funder
Australian Research Council
Funding Amount
$620,000.00
Summary
Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this p .... Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101529
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Transmission dynamics modelling of zoonotic neglected tropical diseases. This project will develop mathematical models to simulate zoonotic disease transmission and control. Results will provide novel insight for policy makers into effective interventions for schistosomiasis, echinococcosis and clonorchiasis, as well as provide a methodological platform for adaptation to other zoonotic emerging and re-emerging diseases.
ARC Centre of Excellence for Plant Success in Nature and Agriculture. The ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre wi ....ARC Centre of Excellence for Plant Success in Nature and Agriculture. The ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre will accelerate technologies to transfer successful networks into crops and build legal frameworks to secure this knowledge. With a uniquely multidisciplinary team, the Centre will deliver new strategies to address the problems of food security and climate change, establishing Australia as a global leader in these areas.Read moreRead less