Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we wi ....Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we will use nuclear magnetic resonance (NMR) spectroscopy. This information will serve as a springboard for future investigations of virus membrane proteins.
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Nutrient generation from rural land and delivery to streams in the Sydney Drinking Water Catchments. The Sydney Catchment Authority must manage pollution arising from land within its catchments. There have been few local studies of nutrient losses from rural land, the major land use, and the understanding of some important processes involved in nutrient generation and delivery is weak. Therefore model predictions are uncertain. This project will quantify nutrient losses from key land uses, ev ....Nutrient generation from rural land and delivery to streams in the Sydney Drinking Water Catchments. The Sydney Catchment Authority must manage pollution arising from land within its catchments. There have been few local studies of nutrient losses from rural land, the major land use, and the understanding of some important processes involved in nutrient generation and delivery is weak. Therefore model predictions are uncertain. This project will quantify nutrient losses from key land uses, evaluate alternative loss pathways, and provide insight into the effects of scale, providing a foundation for improved modelling of nutrient sources and transport. The outcome will be the capacity to prioritise land uses and parts catchments for remedial action, whilst providing a modelling approach relevant to the SCA and other catchment managers.Read moreRead less