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The Development Of A Loop-mediated Isothermal Amplification (LAMP) Assay For The Detection Of Strongyloides Stercoralis In The Stool.
Funder
National Health and Medical Research Council
Funding Amount
$127,494.00
Summary
A new test will be developed for the detection of the worm, Strongyloides stercoralis in the stool. S. stercoralis infects millions of people worldwide and occurs in the north of Australia. It can occasionally cause a ‘hyperinfection’ with fatal consequences. The test is based on the DNA detection method, loop-mediated isothermal amplification (LAMP), which can be performed using simple equipment. The aim will be to make this test as easy possible to perform and to evaluate its effectiveness.
In Vitro And In Vivo Investigation Of Actin Regulation In The Malaria Parasite
Funder
National Health and Medical Research Council
Funding Amount
$92,294.00
Summary
Malaria parasites move in a unique way. They move across cell surfaces and infect human cells using a unique molecular motor that allows them to, literally, glide. The research proposal outlined here is focused on understanding a key part of the motor – the dynamic protein actin – and by understanding how it is regulated develop new potential targets for novel drugs that might stop movement and, therefore, help prevent or treat malaria disease.