This fellowship aims to develop evidence-based clinical and public health approaches to the control of multi-drug resistant tuberculosis. Projects include identifying optimal treatment approaches to drug resistant tuberculosis by using meta-analyses; analysing the cost-effectiveness of strategies to prevent drug resistant tuberculosis; understanding transmission of drug resistance within households and implementing a major clinical trial of antibiotic therapy to prevent the disease.
The biosynthesis of structural proteins in parasites. The socio-economic impact of parasitic diseases, in Australia and throughout the world, is enormous- they kill 2-3 million people per year and cost livestock industries billions of dollars per annum. Some are serious food and waterborne threats, such as the coccidia, because they are transmitted from person-to-person via the faecal-oral route, or via ingestion of contaminated water or food, or through the ingestion of cysts in raw or underco ....The biosynthesis of structural proteins in parasites. The socio-economic impact of parasitic diseases, in Australia and throughout the world, is enormous- they kill 2-3 million people per year and cost livestock industries billions of dollars per annum. Some are serious food and waterborne threats, such as the coccidia, because they are transmitted from person-to-person via the faecal-oral route, or via ingestion of contaminated water or food, or through the ingestion of cysts in raw or undercooked meat. They cause diarrhoea, which in some cases, can be life-threatening. We will understand how the coccidia protect themselves as they move from host to host and, through that understanding, develop new ways to control them and eliminate the suffering caused by parasitic diseases.Read moreRead less
New anti-parasitic drugs for a global veterinary market. This project aims to establish an advanced, industry-linked pipeline for the development of new drugs against resilient infectious agents (parasites) that cause serious diseases in billions of animals worldwide. The research expects to discover new ways of killing parasites that survive in their host animal, despite being under severe attack by the host immune system. The resultant shift in fundamental understanding will lead to innovative ....New anti-parasitic drugs for a global veterinary market. This project aims to establish an advanced, industry-linked pipeline for the development of new drugs against resilient infectious agents (parasites) that cause serious diseases in billions of animals worldwide. The research expects to discover new ways of killing parasites that survive in their host animal, despite being under severe attack by the host immune system. The resultant shift in fundamental understanding will lead to innovative technologies or products to ameliorate the burden of parasites in livestock animals. Expected socioeconomic benefits include commercial products for end-users and lifting Australia’s scientific knowledge base, reputation in biotechnology, livestock production and investment in translational research.Read moreRead less
Prof Paterson is an Infectious Diseases Physician studying the molecular and clinical epidemiology of infections with Gram negative bacteria producing newer beta-lactamases.
I am a public health physician and medical parasitologist determining the mechanism of clinical immunity to malaria, and working on the development of vaccines and therapies against malaria.
Immunisation is second only to clean water and sanitation as a life-saving activity. Vaccine safety is considered to be very important by the general public, the media and the health professions. With so many diseases controlled and now rare, the safety of vaccines assumes greater importance. Research is needed on new and safer vaccines, using e.g. a needle-free approach, against old foes, like influenza, and new enemies (like MERS) with vaccine safety more important than ever.
Loop-mediated Isothermal Amplification(LAMP): A Novel Tool For The Diagnosis Of Mixed Malaria Infections In Elimination Settings
Funder
National Health and Medical Research Council
Funding Amount
$101,877.00
Summary
The malaria elimination agenda will require the development of novel, field applicable diagnostic tools to detect asymptomatic carriers of P.falciparum and non-falciparum malaria infections. Loop-mediated isothermal amplification (LAMP) has been demonstrated to be a novel, sensitive, specific nucleic acid amplification technique. My project aims to optimise LAMP into a high-throughput field applicable molecular diagnostic tool capable of diagnosing malaria in elimination settings
Alternative Pneumococcal Vaccination Schedules For Infants In Fiji And Pneumococcal Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$50,214.00
Summary
The aim of this study is to find a safe and epidemiologically appropriate pneumococcal vaccination strategy for resource poor countries. A single, blind open-label randomized Phase II study is underway in Fiji documenting the safety, immunogenicity and impact on pneumococcal carriage of various pneumococcal vaccination regimens combining 1, 2, or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV) in infancy followed by a single booster dose of 23-valent pneumococcal polysaccharide vaccine.