Improving Outcomes In Osteoporosis And Bone Health
Funder
National Health and Medical Research Council
Funding Amount
$348,494.00
Summary
Osteoporotic fractures are a common and increasing problem as the population ages. They are associated with increased risk of re-fracture and early death yet most patients remain untreated. This proposal will identify which fracture patients are at highest risk of re-fracture and premature death (b) identify whether osteoporosis treatment decreases this risk and (c) increase osteoporosis awareness and treatment uptake by general practitioners with an integrated fracture risk prediction tool.
This fellowship will allow the applicant to continue his studies into understanding and intervening in osteoarthritis. He will use a combination of observational studies and clinical trials to achieve this purpose.
This fellowship will allow the applicant to continue to study the major musculoskeletal diseases in Australia (osteoarthritis, osteoporosis and rheumatoid arthritis) using a combination of observational and interventional studies.
Immunisation is second only to clean water and sanitation as a life-saving activity. Vaccine safety is considered to be very important by the general public, the media and the health professions. With so many diseases controlled and now rare, the safety of vaccines assumes greater importance. Research is needed on new and safer vaccines, using e.g. a needle-free approach, against old foes, like influenza, and new enemies (like MERS) with vaccine safety more important than ever.
Tackling Key Epidemiological And Basic Scientific Research Issues In Prion Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$401,109.00
Summary
Proposed Practitioner Fellowship research will simultaneously include epidemiological and basic scientific projects, emphasising human prion disease. Epidemiological research will involve large-scale studies to clarify genetic factors that influence susceptibility to developing prion disease, as well as clarify whether Alzheimer disease is transmissible, while basic scientific research will include determining the characteristics of the misfolded prion proteins causing neuronal disease.
Implementation Of Highly Effective Therapy For Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
Hepatitis C is a major public health issue in Australia, and globally, with escalating liver disease burden. Highly effective interferon-free HCV regimens will be available from 2016 and have the potential to provide one of the greatest advances in clinical medicine in recent decades. Development of implementation strategies for new HCV therapies, particularly for highly marginalised populations including people who inject drugs and prisoners, is crucial to provide broad public health impact.
Improving Health Outcomes For Disadvantaged Children
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
I am a paediatrician researcher dedicated to improving health and quality of life for ill and disadvantaged children. The focus of my Fellowship will be research in three areas: rare childhood diseases, fetal alcohol spectrum disorder, and vaccine-preventable disease, with attention to diagnosis, treatment and prevention. Alignment of my research and clinical work and my experience in evidence-based medicine will facilitate adoption of my research into clinical care and health policy.
Immunopathogenesis And Manipulation Of The HIV Reservoir
Funder
National Health and Medical Research Council
Funding Amount
$494,732.00
Summary
Kelleher is a Clinical immunologist with a globally recognised, sustained track record of translational research which has impacted both on our understanding of HIV immunopathogenesis and on the way HIV infection is treated. He will conduct a series of studies that encompass basic scientific techniques through to pivotal pre-clinical and clinical studies that will provide a pathway towards control of HIV-infection without daily therapy.
The renewal of my Practitioner Fellowship will continue to facilitate an expanding program of epidemiological and clinical research in viral hepatitis, with a primary focus on hepatitis C. New directions will include development of international clinical cohort and trials networks, particularly to characterise the natural history of early hepatitis C infection and evaluate hepatitis C therapuetic strategies for injecting drug users.
Determinants Of The Outcomes From Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$532,630.00
Summary
Professor Lloyd will continue studies of the factors which lead to varied clinical outcomes from common infectious diseases. The outcomes include chronic or persistent illness, rather than prompt recovery. The factors being studied include aspects of the microbes causing the infection; and aspects of the individual suffering from infection, including genetic make-up, immune defences, and treatment responses. The infections studied include common "flu-like" illnesses, as well as hepatitis C.