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Discovery Early Career Researcher Award - Grant ID: DE160100477
Funder
Australian Research Council
Funding Amount
$335,000.00
Summary
Network modelling nationally important emerging infectious diseases. The project aims to develop decision-support tools for emerging infectious disease outbreaks that build on recent advances in gene sequencing and predictive modelling. Infectious disease transmission depends on the proximity and attributes of infectious and susceptible animals, evolution of the host-pathogen relationship and environmental influences. Recent changes in these have led to a series of major outbreaks with impacts o ....Network modelling nationally important emerging infectious diseases. The project aims to develop decision-support tools for emerging infectious disease outbreaks that build on recent advances in gene sequencing and predictive modelling. Infectious disease transmission depends on the proximity and attributes of infectious and susceptible animals, evolution of the host-pathogen relationship and environmental influences. Recent changes in these have led to a series of major outbreaks with impacts on animal health, productivity and trade. New decision-support tools are required to combine genetic sequences with epidemiological data early in large outbreaks. The intended outcome of the project is that the models developed may enable appropriate and timely intervention and reduce impacts in future outbreaks.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100238
Funder
Australian Research Council
Funding Amount
$379,574.00
Summary
Chlamydial infections of birds, domesticated animals and humans. This project aims to investigate the epidemiology of an avian Chlamydia pathogen that is known to infect humans and animals, causing serious disease. Utilising molecular epidemiology approaches, this project will generate new knowledge about dynamics of where, when and how this infection spill-over occurs between different hosts. This project also aims to extend early development work on an innovative diagnostic system for detectio ....Chlamydial infections of birds, domesticated animals and humans. This project aims to investigate the epidemiology of an avian Chlamydia pathogen that is known to infect humans and animals, causing serious disease. Utilising molecular epidemiology approaches, this project will generate new knowledge about dynamics of where, when and how this infection spill-over occurs between different hosts. This project also aims to extend early development work on an innovative diagnostic system for detection of chlamydia in laboratory and point-of-care scenarios. The expected outcomes are a greatly enhanced understanding of infections in humans and animals caused by this understudied pathogen, which will allow for more effective control and management of these infections.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100030
Funder
Australian Research Council
Funding Amount
$425,486.00
Summary
Improving the use of antimicrobials in Australian veterinary practices. This project aims to understand the drivers for antimicrobial use in veterinary medicine and develop methods to improve appropriate antimicrobial use in animals. This project expects to generate new knowledge in the area of veterinary antimicrobial stewardship using an innovative interdisciplinary approach. The project's use of new technology is expected to result in the development of novel tools that enhance capacity to ad ....Improving the use of antimicrobials in Australian veterinary practices. This project aims to understand the drivers for antimicrobial use in veterinary medicine and develop methods to improve appropriate antimicrobial use in animals. This project expects to generate new knowledge in the area of veterinary antimicrobial stewardship using an innovative interdisciplinary approach. The project's use of new technology is expected to result in the development of novel tools that enhance capacity to address antimicrobial stewardship in veterinary medicine and build institutional collaborations. This should provide significant benefits such as improved antimicrobial use in animals and evidence for which antimicrobial stewardship policicies can be developed in veterinary medicine.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101395
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Effect of disease on reproduction plasticity and evolution in amphibians. The project aims to explore the impact of disease on reproductive success in amphibians by utilizing a holistic approach of both lab and field techniques to understand ecological mechanisms for resilience of wildlife to emerging diseases. The project will explore reproductive effort as a population persistence mechanism of declining species. This should advance knowledge of both reproductive plasticity and evolutionary ada ....Effect of disease on reproduction plasticity and evolution in amphibians. The project aims to explore the impact of disease on reproductive success in amphibians by utilizing a holistic approach of both lab and field techniques to understand ecological mechanisms for resilience of wildlife to emerging diseases. The project will explore reproductive effort as a population persistence mechanism of declining species. This should advance knowledge of both reproductive plasticity and evolutionary adaptation in the face of disease. The expected outcomes include developing targeted approaches for conservation agencies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100735
Funder
Australian Research Council
Funding Amount
$395,204.00
Summary
Understanding infectious laryngotracheitis virus recombination. This project will study the factors that lead to recombination between strains of infectious laryngotracheitis virus (ILTV) concomitant with increased virulence. In previous studies of ILTV, two new genotypes of virulent field strains were shown to be independent recombinants derived from distinct attenuated ILTV commercial vaccines. These strains became the dominant field viruses responsible for widespread and severe disease outbre ....Understanding infectious laryngotracheitis virus recombination. This project will study the factors that lead to recombination between strains of infectious laryngotracheitis virus (ILTV) concomitant with increased virulence. In previous studies of ILTV, two new genotypes of virulent field strains were shown to be independent recombinants derived from distinct attenuated ILTV commercial vaccines. These strains became the dominant field viruses responsible for widespread and severe disease outbreaks in Australian poultry flocks. This project will enhance understanding of the conditions that led to these deleterious natural recombination events and enable the industry to avoid the emergence of new virulent field strains in the future. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100121
Funder
Australian Research Council
Funding Amount
$452,824.00
Summary
Effects of environmental heat stress on male fertility in livestock species. This project aims to address the role of ambient heat stress in animal fertility by examining its mechanisms and developing treatments to alleviate its effects. Using an interdisciplinary approach that brings together veterinary sciences, reproductive biology, biochemistry and bioinformatics, the project expects to improve our understanding of how high environmental temperatures lead to reduced fertility, pregnancy loss ....Effects of environmental heat stress on male fertility in livestock species. This project aims to address the role of ambient heat stress in animal fertility by examining its mechanisms and developing treatments to alleviate its effects. Using an interdisciplinary approach that brings together veterinary sciences, reproductive biology, biochemistry and bioinformatics, the project expects to improve our understanding of how high environmental temperatures lead to reduced fertility, pregnancy loss and compromised inheritance in large animals, and to develop effective interventions. The resulting benefits include enhanced productivity and resilience of Australia’s livestock industries in the face of a changing climate.
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Discovery Early Career Researcher Award - Grant ID: DE140100135
Funder
Australian Research Council
Funding Amount
$395,199.00
Summary
Understanding equine incretins: a novel approach to laminitis prevention. Laminitis is a crippling foot disease in horses which incurs significant economic and social costs. Recent studies have shown that persistently high insulin concentrations can trigger laminitis, and that high insulin levels are caused by the excessive release of hormones called incretins. This project aims to determine the role of incretins and their receptors in causing abnormal equine insulin secretion. The distribution ....Understanding equine incretins: a novel approach to laminitis prevention. Laminitis is a crippling foot disease in horses which incurs significant economic and social costs. Recent studies have shown that persistently high insulin concentrations can trigger laminitis, and that high insulin levels are caused by the excessive release of hormones called incretins. This project aims to determine the role of incretins and their receptors in causing abnormal equine insulin secretion. The distribution of equine incretin receptors will be described for the first time, and the consequences of incretin receptor binding will be characterised. Understanding equine incretin biology may lead to novel therapies for laminitis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101701
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A porcine model to provide new insights on scabies immunopathology. Scabies is a poorly understood parasitic disease of medical and veterinary significance. This project will use a world-first experimental model to investigate the progression of host immune responses in scabies, which will enable the development of new control strategies for this neglected disease.
Discovery Early Career Researcher Award - Grant ID: DE240100295
Funder
Australian Research Council
Funding Amount
$455,563.00
Summary
Unlocking the helminth ‘early infection gap’ using 3D cell culture models. This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the earl ....Unlocking the helminth ‘early infection gap’ using 3D cell culture models. This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the early infection process. Expected outcomes include new knowledge on key migratory stimuli and liver fluke biology. Benefits include the identification of drug targets and vaccine candidates for use in livestock via the development of animal-free in vitro screening platforms that will serve as a prototype for other parasites.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101063
Funder
Australian Research Council
Funding Amount
$462,948.00
Summary
Bacterial cell invasion factors as vaccine targets. This project aims to determine the virulence factors responsible for cellular invasion and systemic spread of Mycoplasma bovis, and use genome editing technologies (CRISPR-Cas9) to create gene knock out mutants that cannot invade host cells and test their potential as vaccine candidates in animals. Mycoplasma bovis is an emerging cause of mastitis, the most important infectious disease in the dairy industry, and causes significant economic loss ....Bacterial cell invasion factors as vaccine targets. This project aims to determine the virulence factors responsible for cellular invasion and systemic spread of Mycoplasma bovis, and use genome editing technologies (CRISPR-Cas9) to create gene knock out mutants that cannot invade host cells and test their potential as vaccine candidates in animals. Mycoplasma bovis is an emerging cause of mastitis, the most important infectious disease in the dairy industry, and causes significant economic losses. The vaccine candidates developed in this project are expected to be used to control outbreaks of mastitis, and to improve biosecurity, production and animal welfare in the Australian and global dairy industries.Read moreRead less