Exercise As Medicine For Heart Failure: A Novel Intervention To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$665,585.00
Summary
Heart failure (HF) is a common, debilitating and expensive disease; prognosis remains poorer than for the most cancers. 30,000 Australians are diagnosed every year and 300,000 live with the HF, at an annual cost of ~$1Billion. Exercise training is effective therapy in HF, because it reverses many of the problems that contribute to the reduced lifespan and impaired quality of life of patients with HF. We will test an exciting new type of exercise that promising greater benefit, at lower risk.
Developmental Origins Of Adult Cardiovascular Disease: Vascular Health In The Raine Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,087,427.00
Summary
The Raine study is a unique long term experiment that has collected extensive pre-birth and childhood data in ~3000 young Australians, who are now 27 years old. We plan to measure the artery health of 1200 of these volunteers and to determine what factors, both before and after birth, influence the presence of early atherosclerosis in humans. This study will guide strategies aimed at early prevention of heart attacks and stroke in humans, by defining the major risk factors.
Police Leadership in the 21st Century: Redesigning Roles and Practices. Leaders are seen as exemplifying and guiding the climate of police organisations. This project will deliver comprehensive, comparative, and internationally relevant empirical data on the relationship between leaders' approach and behaviours and the achievement of outcomes in these significant, high profile public sector organisations. On this foundation the project will make recommendations on innovative institutional desi ....Police Leadership in the 21st Century: Redesigning Roles and Practices. Leaders are seen as exemplifying and guiding the climate of police organisations. This project will deliver comprehensive, comparative, and internationally relevant empirical data on the relationship between leaders' approach and behaviours and the achievement of outcomes in these significant, high profile public sector organisations. On this foundation the project will make recommendations on innovative institutional design to achieve ethical, effective and efficient policing capable of withstanding the challenges of the future. This will increase public confidence in policing, resulting in safer communities and improved crime control. This proposal contributes to the ARC research priority of Safeguarding Australia.Read moreRead less
International Operations and the Australian Federal Police: Devising a legal framework. As a major player in the maintenance of regional peace and security, Australia is increasingly using Australian Federation Police (AFP) in a range of international operations. The extent of deployments and the expectations both governments and communities place on these operations is unprecedented. This project, in collaboration with the AFP, will draw upon recent experiences to provide a clear legal framewo ....International Operations and the Australian Federal Police: Devising a legal framework. As a major player in the maintenance of regional peace and security, Australia is increasingly using Australian Federation Police (AFP) in a range of international operations. The extent of deployments and the expectations both governments and communities place on these operations is unprecedented. This project, in collaboration with the AFP, will draw upon recent experiences to provide a clear legal framework, advancing the capacity for AFP deployments to maintain their high commitment to the rule of law. The project is of international significance and will consolidate Australia's reputation as innovative and influential in the planning, management and conduct of police in international operations. Read moreRead less
Adult Sexual Assault: An evidence-based policy, practice and advocacy model for Victoria Police. Sexual violence causes long term health and economic costs. One Australian study estimates the fiscal cost to victims and the community as 230m dollars per year. The trauma of the assault is often compounded by police investigative processes that victims find alienating and demeaning. Eliminating significant barriers to police reporting and creating a more just criminal response is essential. Sexual ....Adult Sexual Assault: An evidence-based policy, practice and advocacy model for Victoria Police. Sexual violence causes long term health and economic costs. One Australian study estimates the fiscal cost to victims and the community as 230m dollars per year. The trauma of the assault is often compounded by police investigative processes that victims find alienating and demeaning. Eliminating significant barriers to police reporting and creating a more just criminal response is essential. Sexual assault is recognised globally as a Human Rights issue that is receiving increasing attention by governments in Australia. This project will result in the implementation of a policing model that advances the rights and welfare of victims therefore contributing an important step in ameliorating some of the documented health consequences.
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Transcriptional Control Of Blood Vessel Development By Sox18
Funder
National Health and Medical Research Council
Funding Amount
$468,564.00
Summary
Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of ....Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of fundamental importance in the health sciences to gain an understanding of how blood vessels form and regenerate. As a result of our collaborative research efforts, we have discovered a gene, Sox18, that appears to regulate blood vessel development by controlling the formation and-or behaviour of endothelial cells, which line the blood vessels and make them impermeable. Our research so far indicates that MICE WITH DEFECTS IN SOX18 DIE FROM VASCULAR DEFECTS, underlining the importance of this gene. THIS PROJECT IS CONCERNED WITH FINDING OUT HOW SOX18 WORKS - exactly what goes wrong in mice lacking this gene, whether Sox18 can influence endothelial cell behaviour in cell culture, how Sox18 comes to be active in endothelial cells, what genes are switched on by Sox18, and what genes Sox18 co-operates with in its role in endothelial cells. The answers to these questions will not only provide fundamental basic information about how blood vessels development is controlled, but also sow the seeds for possible future therapies in which blood vessel development could be stimulated (eg in wound healing) or suppressed (eg in tumour progression) through pharmaceutical intervention.Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Optical coherence elastography - High-resolution medical imaging of tissue mechanical properties. This project brings together an international, multi-disciplinary team to develop innovative, high-resolution techniques to identify diseased tissue. Success will result in a new medical imaging technique allowing clinicians to quantify the mechanical properties of tissue, effectively creating a high-resolution image of what the tissue 'feels' like. This may help them to more accurately identify can ....Optical coherence elastography - High-resolution medical imaging of tissue mechanical properties. This project brings together an international, multi-disciplinary team to develop innovative, high-resolution techniques to identify diseased tissue. Success will result in a new medical imaging technique allowing clinicians to quantify the mechanical properties of tissue, effectively creating a high-resolution image of what the tissue 'feels' like. This may help them to more accurately identify cancerous tissue during surgery and reduce rates of recurrence. It could aid in tissue engineering and regeneration and will provide a new database of tissue mechanical properties. The project will position Australia as a leader in this newly developing medical imaging technology, with significant potential for commercialisation.Read moreRead less
Three dimensional (3D) optical coherence tomography in cancer. This project will establish for the first time how well 3D optical coherence tomography, a form of medical imaging, can image cancer. Based on this, a version built into a needle will be developed which will enable extension much deeper into tissues than previously possible to image cancer and to guide related surgical procedures.