Role Of Epigenomic Changes In Conferring Hyperglycemic Memory
Funder
National Health and Medical Research Council
Funding Amount
$636,146.00
Summary
The major burden of type I diabetes remains its vascular complications including diabetes-accelerated athersclerosis. Despite improved glucose control, diabetic individuals develop complications as a result of prior poor glycemic control. Although the development and progression of these diabetic complications is strongly associated with mean levels of glucose, recent studies suggest that the deleterious effects of early exposure to high levels of glucose persist for years even after treatment h ....The major burden of type I diabetes remains its vascular complications including diabetes-accelerated athersclerosis. Despite improved glucose control, diabetic individuals develop complications as a result of prior poor glycemic control. Although the development and progression of these diabetic complications is strongly associated with mean levels of glucose, recent studies suggest that the deleterious effects of early exposure to high levels of glucose persist for years even after treatment has returned glucose levels towards normal.Read moreRead less
Policing the border: security, human rights and gender. Women are the fastest growing group undertaking extra-legal border crossing, yet we know little about the gendered character of border enforcement. This project will develop a regulatory framework for border policing that is adaptable to the gender determinants of mobility, human rights and the future challenges of border management.
Policing services and the mentally ill: An evidence-based good practice model. Community safety is at the forefront of policing policy and procedure. As gatekeepers to the criminal justice (and to a lesser extent the mental health) systems, the police play a pivotal role in promoting and maintaining the health, safety and wellbeing of the community. This programme of research will provide much needed quality information and empirical evidence about the current practices, policies, and procedures ....Policing services and the mentally ill: An evidence-based good practice model. Community safety is at the forefront of policing policy and procedure. As gatekeepers to the criminal justice (and to a lesser extent the mental health) systems, the police play a pivotal role in promoting and maintaining the health, safety and wellbeing of the community. This programme of research will provide much needed quality information and empirical evidence about the current practices, policies, and procedures for dealing with the mentally ill who come into contact with the police. In a broader sense the research will have dramatic, wide-reaching practical outputs for all of Australia, and help contribute to increased levels of community safety and reduced levels of victimisation of some of the most vulnerable in our society.Read moreRead less
The Role Of Dicarbonyl-derived AGEs And RAGE In Diabetes Associated Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$470,617.00
Summary
Based on our pilot data we postulate that glucose derived molecules such as methylglyoxal (MGO) have effects on inflammation and oxidative stress leading to accelerated atherosclerosis in diabetes. Our studies aim to identify novel treatments which block these effects thus leading to superior protection and prevention of atherosclerosis in diabetes.
Vascular Cognitive Risk Score: Quantifying The Vascular Burden In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$627,180.00
Summary
What causes dementia in a patient presenting to a clinic is often uncertain. While there are exciting potential treatments in the pipeline, we need to understand the cause of the disease in a specific patient to make correct treatment decisions. Stroke and other vascular diseases of the brain cause a significant proportion of dementia in the community. Using MRI scanning technology, this project will quantify this burden in a given patient by developing a ‘vascular cognitive risk' (VCR) score.
Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
Discovery Early Career Researcher Award - Grant ID: DE240100109
Funder
Australian Research Council
Funding Amount
$460,157.00
Summary
Sexual offence interviewing: Towards victim-survivor well-being and justice. This project aims to improve the way victim-survivors are interviewed in sexual offence cases by examining their experiences and perceptions of investigative interview techniques. It expects to generate new knowledge about interview techniques that can promote victim well-being and the disclosure of sensitive information during investigative interviews. Expected outcomes include new theoretical frameworks in the field o ....Sexual offence interviewing: Towards victim-survivor well-being and justice. This project aims to improve the way victim-survivors are interviewed in sexual offence cases by examining their experiences and perceptions of investigative interview techniques. It expects to generate new knowledge about interview techniques that can promote victim well-being and the disclosure of sensitive information during investigative interviews. Expected outcomes include new theoretical frameworks in the field of investigative interviewing and an innovative toolkit of victim-centred training resources to directly inform investigative interview policies and practices in sexual offence cases. Anticipated benefits include better victim experiences of investigative interviews and enhanced justice responses to sexual violence.Read moreRead less
A model of sex offender registration, monitoring, and risk management. This research will investigate the ways in which sexual offenders are managed in the community and identify the most effective means of preventing further offending, thereby promoting community safety.
Targeted crime: policing and social inclusion. This project will undertake a criminological study of the policing of targeted incidents and crime, that is, incidents and crimes motivated by bias, prejudice or hatred towards members of particular groups, communities and individuals. It will develop a best practice policing framework for targeted crimes and incidents.
Use of an animal model to understand mechanisms underlying reductions in body weight associated with use of the laparoscopic adjustable gastric band. At least one in ten Australians is classified as morbidly obese and as such are eligible for bariatric surgery. Those undergoing the surgery will achieve an average excess weight loss of up to 60 per cent, they will have reduced or eliminated diabetes and will appreciably improve their prospects of survival. These experiments aimed at understandin ....Use of an animal model to understand mechanisms underlying reductions in body weight associated with use of the laparoscopic adjustable gastric band. At least one in ten Australians is classified as morbidly obese and as such are eligible for bariatric surgery. Those undergoing the surgery will achieve an average excess weight loss of up to 60 per cent, they will have reduced or eliminated diabetes and will appreciably improve their prospects of survival. These experiments aimed at understanding the mechanisms underpinning this success have the potential to further improve surgical approaches and outcomes and provide insights that will better enable weight loss therapies for all overweight and obese Australians.Read moreRead less