Bioengineering Synthetic Elastin Conduits For Arterial Revascularisation
Funder
National Health and Medical Research Council
Funding Amount
$624,776.00
Summary
An arterial substitute with both physical and biological properties that mimic those of the human vasculature has long been the holy grail of vascular tissue engineering. We propose synthetic elastin can form the basis of a durable, clinically effective small diameter vascular graft and fill a significant unmet need for a biocompatible vascular substitute.
Biocompatible Synthetic Conduits To Treat Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$421,818.00
Summary
Clinically available synthetic conduits used in vascular repair and bypass are fundamentally incompatible with the vasculature. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of all polymeric materials and have shown a significant improvement in their compatibility. Grafts coated using our technology stand to dramatically improve the treatment of vascular diseas ....Clinically available synthetic conduits used in vascular repair and bypass are fundamentally incompatible with the vasculature. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of all polymeric materials and have shown a significant improvement in their compatibility. Grafts coated using our technology stand to dramatically improve the treatment of vascular disease.Read moreRead less
Bioengineering Endovascular Prostheses With Proactive Biocompatibility
Funder
National Health and Medical Research Council
Funding Amount
$627,950.00
Summary
Metallic cardiovascular implants, such as stents, used in the treatment of heart disease are not compatible with blood. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of metal alloys, and shown a significant improvement in their compatibility. Stents coated using our technology stand to dramatically improve the treatment of cardiovascular disease.
Development Of Endovascular Stents With Proactive Biocompatibility
Funder
National Health and Medical Research Council
Funding Amount
$428,470.00
Summary
Metallic cardiovascular implants, such as stents, used in the treatment of heart disease are not compatible with blood. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of metal alloys, and shown a significant improvement in their compatibility. Stents coated using our technology stand to dramatically improve the treatment of cardiovascular disease.
Broad spectrum nanomedicine for Meningitis treatment. Brain inflammatory diseases are among the top ten infectious causes of death. The project aims to provide Australian doctors with a superior alternative of treating infections that do not respond to conventional antibiotics. The nanomedicine developed will reduce the burden of hospital and boost Australia economy in the biomedical sector.
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
Bioreactors for manufacture of human platelets. Blood cell transfusion is a critical part of medicine that is supported by volunteer donors. Unfortunately, the demand for blood cells for transfusion far outstrips supply and therefore new strategies are required for manufacture of blood cells. This project will lead to the development of technology for manufacture of human platelets from stem cells. The systems devised will be applicable to a broad range of other blood cell types.
Functional Electronic Stimulation of Muscles - Development of a Model for Sensory Feedback to Amputees and Vision for the Blind. Electrical stimulation of nerve fibres is an emerging physiological technique with great promise towards rehabilitation. The field lacks techniques for detailed, focal application of stimuli to recruit specific fibres for fine muscle control or conveying useful neurosensory information. The investigator has developed microtechnology for delivering stimuli to 100 sites, ....Functional Electronic Stimulation of Muscles - Development of a Model for Sensory Feedback to Amputees and Vision for the Blind. Electrical stimulation of nerve fibres is an emerging physiological technique with great promise towards rehabilitation. The field lacks techniques for detailed, focal application of stimuli to recruit specific fibres for fine muscle control or conveying useful neurosensory information. The investigator has developed microtechnology for delivering stimuli to 100 sites, conceivably facilitating recruitment of specific fibres within a given bundle. Effects of muscle stimulation are readily measured and shall be used to model and refine techniques for generic high-resolution fibre recruitment. Benefits include, improved muscle control in functional electrical stimulation, sensory perception for amputees and patterned vision from optic nerve stimulation.Read moreRead less
Conformal Bionics - addressing the challenges in bringing miniaturised implants to the site of therapeutic delivery. Smaller, more sophisticated, lifetime-implantable bionic devices capable of being placed at the site of therapeutic delivery will facilitate new or improved opportunities for treatment of disease. Three critical areas of research aim to be explored in pursuit of this goal will be addressed within this study: introduction of new fabrication materials that enable devices to conform ....Conformal Bionics - addressing the challenges in bringing miniaturised implants to the site of therapeutic delivery. Smaller, more sophisticated, lifetime-implantable bionic devices capable of being placed at the site of therapeutic delivery will facilitate new or improved opportunities for treatment of disease. Three critical areas of research aim to be explored in pursuit of this goal will be addressed within this study: introduction of new fabrication materials that enable devices to conform to the anatomy of the targeted site of therapeutic delivery; improved means of addressing the data and energy transfer needs of devices implanted in confined spaces; and innovation of novel sensors for testing and monitoring of atmospheric conditions within the implant to anticipate and safely manage issues relating to a breach of hermetic encapsulation barriers.Read moreRead less