Characterisation Of The Biochemical And Cell Biological Mechanisms Of Cross-presentation In Dendritic Cells
Funder
National Health and Medical Research Council
Funding Amount
$303,828.00
Summary
The immune system possesses several mechanisms to fight viruses and cancer. One of these mechanisms consists of recruiting anti-virus or anti-cancer killer cells. These killer cells are recruited by specialized cells known as Dendritic Cells (DC). The DC are distributed all over the body, and can detect the presence of viruses or cancer cells. When they do, they take up chunks of the virus or cancer cells, break them into small pieces called antigens, and display these antigens on their surface, ....The immune system possesses several mechanisms to fight viruses and cancer. One of these mechanisms consists of recruiting anti-virus or anti-cancer killer cells. These killer cells are recruited by specialized cells known as Dendritic Cells (DC). The DC are distributed all over the body, and can detect the presence of viruses or cancer cells. When they do, they take up chunks of the virus or cancer cells, break them into small pieces called antigens, and display these antigens on their surface, where they can be seen by the killer cells. This initiates an immune response whereby the killer cells seek and destroy the viruses and cancer cells. We are trying to harness the ability of DC to initiate immune responses in order to design more efficient vaccines to fight viruses and cancer. Our goal is to deliver vaccines that will directly target the DC and induce the formation of protective killer cells. These strategies require us to overcome two problems. The first is that we possess different types of DC, which play distinct functions, but we do not know which type is the most effective at recruiting killer cells, or why. The second problem is that we need to understand which vaccine design is the most effective at promoting presentation of the antigens that will be used to induce killer cells. The goal of this research project is to learn how we should deliver antigens to which DC type to generate the best possible vaccine.Read moreRead less
Microwave System for Early Breast Cancer Detection Employing Ultra Wideband Conformal Array Antenna. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniqu ....Microwave System for Early Breast Cancer Detection Employing Ultra Wideband Conformal Array Antenna. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniques have attracted considerable interest as viable alternatives to X-ray mammography. This project aims at the design and development of a low-cost microwave system, which will complement all the currently available breast cancer diagnosis tools. Read moreRead less
Microwave System for Breast Cancer Detection. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniques have attracted considerable interest as viable alter ....Microwave System for Breast Cancer Detection. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniques have attracted considerable interest as viable alternatives to X-ray mammography. This project aims at the design and development of a low-cost microwave system, which will complement X-ray mammography as a breast cancer diagnosis tool. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453561
Funder
Australian Research Council
Funding Amount
$336,706.00
Summary
Integrated Precision Machining of Complex Profiles. High precision and high speed machining is of central importance to the development of a wide range of frontier technologies such as precision manufacturing, nano-materials fabrication, semiconductor and composite processing, vehicle production and steel structure manufacturing. The research significance has been well established by the world-leading projects and achievements. The proposed facility has distinct features and capability of high l ....Integrated Precision Machining of Complex Profiles. High precision and high speed machining is of central importance to the development of a wide range of frontier technologies such as precision manufacturing, nano-materials fabrication, semiconductor and composite processing, vehicle production and steel structure manufacturing. The research significance has been well established by the world-leading projects and achievements. The proposed facility has distinct features and capability of high loop-stiffness, high repeatability, universal profiling, organic integration of key machining operations, and great flexibility of both low and high speeds. These unique characteristics will enable the innovative development of many research programs which will otherwise be impossible to achieve.Read moreRead less
High-Performance Microwave and Millimetre Wave Antennae Based on Multi-layer Periodic Structures. Broadband communication has created a rapidly growing market for innovative microwave communication systems such as WiFi and WiMAX. Millimetre-wave technology is expected to deliver the next leap in communication technology with much faster wireless links for 3D TV etc. By developing innovative, low-cost, planar antennas with high performance, the proposed research will create opportunities for Aust ....High-Performance Microwave and Millimetre Wave Antennae Based on Multi-layer Periodic Structures. Broadband communication has created a rapidly growing market for innovative microwave communication systems such as WiFi and WiMAX. Millimetre-wave technology is expected to deliver the next leap in communication technology with much faster wireless links for 3D TV etc. By developing innovative, low-cost, planar antennas with high performance, the proposed research will create opportunities for Australian industry to compete in this growing global market with advanced, cost-effective, microwave and millimetre-wave products. The Australian research community will benefit from new methods, techniques and trained researchers, while Australian consumers will benefit from improved quality and low cost of services.Read moreRead less
Hybrid-resonator antennas for wireless communication networks. The rapid emergence of modern wireless communication systems has led to a requirement for small, lightweight antennas. In this project, a new, broadband, low-cost, small and lightweight antenna architecture will be developed for wireless systems. The new architecture is based on a novel hybrid-resonator concept: a dielectric resonator tightly coupled to a metal patch resonator. The rapid design and optimisation of new antennas will b ....Hybrid-resonator antennas for wireless communication networks. The rapid emergence of modern wireless communication systems has led to a requirement for small, lightweight antennas. In this project, a new, broadband, low-cost, small and lightweight antenna architecture will be developed for wireless systems. The new architecture is based on a novel hybrid-resonator concept: a dielectric resonator tightly coupled to a metal patch resonator. The rapid design and optimisation of new antennas will be achieved by developing several new theoretical methods. Antennas targeted for the Unlicensed National Information Infrastructure (UNII) band (5-6 GHz) commercial wireless communication systems will be designed, fabricated, tested and integrated with the systems.
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Integration of Wireless LAN and GPRS/UMTS Cellular Systems. Integration of wireless local area networks with cellular mobile systems provides a feasible, reliable, and cost-effective way for high-speed mobile Internet access in wide area networks. In this project in collaboration with Australia's second largest telecommunications company; Optus, we will develop network architecture and essential access and mobility techniques for such a system. The project's outcomes will enable Optus to expand ....Integration of Wireless LAN and GPRS/UMTS Cellular Systems. Integration of wireless local area networks with cellular mobile systems provides a feasible, reliable, and cost-effective way for high-speed mobile Internet access in wide area networks. In this project in collaboration with Australia's second largest telecommunications company; Optus, we will develop network architecture and essential access and mobility techniques for such a system. The project's outcomes will enable Optus to expand its broadband mobile Internet service to all parts and population of the country including rural and regional areas and subsequently export the breakthrough technology resulted from the project to overseas.Read moreRead less