Chemical synthesis of cancer-associated glycoproteins. Glycosylation of proteins is an extremely common event which plays an important role in a variety of biological processes. Aberrant glycosylation and over-production of glycoproteins is associated with numerous cancer types (including breast, prostate, ovarian and small lung) and are recognised as promising agents for disease diagnosis and vaccine development. A range of cancer-associated glycoproteins will be synthesised in this research p ....Chemical synthesis of cancer-associated glycoproteins. Glycosylation of proteins is an extremely common event which plays an important role in a variety of biological processes. Aberrant glycosylation and over-production of glycoproteins is associated with numerous cancer types (including breast, prostate, ovarian and small lung) and are recognised as promising agents for disease diagnosis and vaccine development. A range of cancer-associated glycoproteins will be synthesised in this research program using a number of novel chemical technologies. These glycoproteins will be used to develop cancer vaccines and diagnostics. Cancer is a severe burden on the Australian community and on the economy, therefore this research will be of significant benefit to Australia.Read moreRead less
Amino Acid and Peptide Radicals in Biochemistry and Synthesis. The aim of this research is to develop a better fundamental understanding of biochemical free radical reactions of peptides and proteins, particularly those involving superoxide radical anion and thiols, and peptide radicals in enzyme-catalysed reactions. Knowledge gained through this work will be used in the synthesis of physiologically active amino acids and peptides, as well as to establish ways to regulate biochemical free radic ....Amino Acid and Peptide Radicals in Biochemistry and Synthesis. The aim of this research is to develop a better fundamental understanding of biochemical free radical reactions of peptides and proteins, particularly those involving superoxide radical anion and thiols, and peptide radicals in enzyme-catalysed reactions. Knowledge gained through this work will be used in the synthesis of physiologically active amino acids and peptides, as well as to establish ways to regulate biochemical free radical processes. The ultimate goal of the research is to develop methods and pharmaceutical compounds to prevent and treat human disorders associated with these reactions, and to underpin commercial exploitation of peptide and protein biomaterials.Read moreRead less