The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, ....The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, and targeted epidemiology and disease modelling vaccine preventable disease will also allow a broad program of research, enabling training and mentoring of young clinical nurse and physician researchers. Collaborations with existing national immunisation, infectious diseases and research institutions will allow maximal effectiveness of clinical studies.Read moreRead less
Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Determining implementation drivers in resilience education. Determining implementation drivers in resilience education. This project aims to develop implementation frameworks to help the education sector universally provide resilience education programmes. More young people have mental health problems. Although evidence-based resilience education reduces these problems, education sectors do not know how to address barriers to school provision. The solution is implementation research. This projec ....Determining implementation drivers in resilience education. Determining implementation drivers in resilience education. This project aims to develop implementation frameworks to help the education sector universally provide resilience education programmes. More young people have mental health problems. Although evidence-based resilience education reduces these problems, education sectors do not know how to address barriers to school provision. The solution is implementation research. This project will study system and school-level factors influencing primary and high school uptake of social and emotional learning curricula that enhance resilience; and implementation drivers at both system and school levels, and influences on uptake and student and staff resilience. The outcome is universal provision of resilience education programs that benefit young people.Read moreRead less
Incentivising On Country Aboriginal Employment: Anangu Futures. . This project aims to investigate the changing face of cultural tourism in central Australia and examine pathways towards sustainable aboriginal employment in and around Uluru-Kata Tjuta National Park. The project is significant because it brings together Aboriginal community members, industry and government stakeholders to identify micro-business opportunities, youth training initiatives, better relations across cultural divides, ....Incentivising On Country Aboriginal Employment: Anangu Futures. . This project aims to investigate the changing face of cultural tourism in central Australia and examine pathways towards sustainable aboriginal employment in and around Uluru-Kata Tjuta National Park. The project is significant because it brings together Aboriginal community members, industry and government stakeholders to identify micro-business opportunities, youth training initiatives, better relations across cultural divides, and the economic value of Aboriginal knowledge. Outcomes include a model for sustainable Aboriginal employment in remote and very remote contexts, and the development of culturally relevant and sustainable governing guidelines for regional investment. Benefits include more sustainable jobs for Aboriginal people.Read moreRead less
School drug education for junior high school students in Victoria - Assessing the impact of a state-wide, evidence-based intervention
. Young people are faced with numerous and powerful influences to use both legal and illicit drugs, and drug education can play an important counterbalancing role in shaping a normative culture of safety, moderation and informed decision making in this group. The research will develop, implement and evaluate one all encompassing, evidence-based, drug education pr ....School drug education for junior high school students in Victoria - Assessing the impact of a state-wide, evidence-based intervention
. Young people are faced with numerous and powerful influences to use both legal and illicit drugs, and drug education can play an important counterbalancing role in shaping a normative culture of safety, moderation and informed decision making in this group. The research will develop, implement and evaluate one all encompassing, evidence-based, drug education program for junior high school students across Victoria. The study is unique in its size and scope and will be of national benefit because its findings will influence the nature of future drug education in all secondary schools in Australia.Read moreRead less
Immunising Aboriginal Mothers With Pneumococcal Polysaccharide Vaccine To Prevent Infant Ear Disease And Carriage
Funder
National Health and Medical Research Council
Funding Amount
$1,131,530.00
Summary
Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are nee ....Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are needed to eliminate, or at least delay, this early-onset pneumococcal colonisation. One such strategy is the administration to the mother of pneumococcal vaccine, which may protect the newborn infant by leading to higher titres of transplacental or breast milk pneumococcal antibodies and-or by reducing carriage (and transmission to the infant) of maternal pneumococci. Previous small studies using this strategy have been encouraging, but there have been no studies properly evaluating carriage or disease endpoints in infants. The polysaccharide pneumococcal vaccine is currently recommended for all Aboriginal and Torres Islander persons aged 15 years or more in the Northern Territory but uptake of the vaccine has been poor. We propose to conduct a pilot study to determine if maternal immunisation with this vaccine, either in the third trimester of pregancy of immediately following delivery, can reduce pneumococcal carriage and the prevalence of middle ear disease among Aboriginal infants at seven months of age. We aim to recruit 210 Aboriginal women who have uncomplicated pregnancies from Darwin and remote communities in the Top End of the Northern Territory. Each subject and their infant offspring will be followed-up after vaccination and at birth, one , two and seven months after birth.Read moreRead less
Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. ....Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. It seeks to improve understanding of the incidence, spatial patterns and drivers of migrants’ movement within Australia and the socio-demographic impact on regions and individuals. Such understanding is an essential first step to the formulation of effective immigration and settlement policies and programs.Read moreRead less
Challenges, Possibilities and Future Directions: A National Assessment of Australia's Children's Courts. Children's Courts occupy a unique position in the child welfare and juvenile justice systems in responding to often marginalized delinquent youth and vulnerable children and families. Philosophical and structural shifts in Australia and overseas suggest community and legal system responses are often ineffective and contribute to longer-term problems, creating social challenges for governments ....Challenges, Possibilities and Future Directions: A National Assessment of Australia's Children's Courts. Children's Courts occupy a unique position in the child welfare and juvenile justice systems in responding to often marginalized delinquent youth and vulnerable children and families. Philosophical and structural shifts in Australia and overseas suggest community and legal system responses are often ineffective and contribute to longer-term problems, creating social challenges for governments and communities alike. This national study will examine how key stakeholders, including, significantly, judicial officers, view the Children's Court's contemporary responses and challenges, their preferred alternatives responses and the viability of suggested reforms, thus offering a unique contribution to informing legal and social policy change.Read moreRead less
Implementing Indigenous knowledge approaches in doctoral education . This project aims to apply Indigenous knowledge approaches (agency of Country; power of stories and iterative, intergenerational and intercultural knowledge production) to Australian doctoral education. This project expects to generate new knowledge in the area of Indigenous and transcultural (migrant, refugee and international) doctoral education. Expected outcomes of the project include multimedia portal/app and policy recomm ....Implementing Indigenous knowledge approaches in doctoral education . This project aims to apply Indigenous knowledge approaches (agency of Country; power of stories and iterative, intergenerational and intercultural knowledge production) to Australian doctoral education. This project expects to generate new knowledge in the area of Indigenous and transcultural (migrant, refugee and international) doctoral education. Expected outcomes of the project include multimedia portal/app and policy recommendations for doctoral supervision, language and examination protocols that place Indigenous and transcultural knowledges at the forefront of Australian research. This should provide significant benefits to Australian higher education, enabling Australia to become a world leader in global knowledge production. Read moreRead less