Informing Vaccination Strategies For Pregnant Women Through Linked Population Health Data
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Vaccination during pregnancy has health benefits for mothers and their infants; however, it is a relatively new area of research, and the immediate and long-term consequences for children are currently not well understood. As part of this fellowship, I plan to conduct research into the long-term health impacts of vaccination during pregnancy. This fellowship will build my career as a perinatal epidemiologist and establish expertise in Australia related to vaccines given during pregnancy.
Asia-Pacific Pneumococcal Disease Control In The Pneumococcal Conjugate Vaccine Era
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
Pneumonia is one of the commonest causes of childhood death worldwide. PCV is a vaccine that prevents pneumonia but it is costly; and causes an increase in disease from strains which are not in the vaccine. Our CRE will address 2 outstanding issues: when to switch from a 3 to 2 dose PCV schedule to make it more affordable; and create new understanding of the non-vaccine strains’ impact on disease in low- and middle-income countries in the Asia-Pacific region.
Investigating The Altered Landscape Of Enteric Viruses Causing Severe Gastroenteritis In Australian Children Following Rotavirus Vaccine Introduction
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
The rotavirus vaccines were introduced in Australia in 2007, decreasing rotavirus disease. Rotavirus strains naturally evolve during replication, however, high vaccine coverage in the population creates a new environment with different evolutionary pressures where strains not protected by the vaccines may emerge and become dominant. The diminished circulation of rotavirus may create an environment where other viruses capable of causing childhood gastroenteritis may increase.
Links2HealthierBubs: Influenza And Pertussis Vaccine Effectiveness And Safety In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$676,333.00
Summary
Vaccination during pregnancy can offer protection against severe respiratory disease for infants in the first six months of life. For this reason, influenza and pertussis vaccines are routinely recommended during each pregnancy. Unfortunately, little is known about the ‘real world’ effect of both vaccines. We plan to conduct the largest and most comprehensive study to date to evaluate all vaccines routinely recommended in pregnancy in Australia.
Expression Of Malaria Parasite Invasion Associated Proteins In The Sporozoite Novel Vaccination Strategy
Funder
National Health and Medical Research Council
Funding Amount
$202,000.00
Summary
Efforts to develop vaccines against malaria still represent a substantial focus of current research activities. Antigens present in the erythrocytic pathogenic stages of the infection account for the majority of targets investigated for potential vaccines. Experimental vaccines targeting the pre-erythrocytic stages [the sporozoite injected by the mosquito, and the hepatic stage parasite) have encompassed a lesser diversity of parasite antigens]. This is the case despite the fact that experimenta ....Efforts to develop vaccines against malaria still represent a substantial focus of current research activities. Antigens present in the erythrocytic pathogenic stages of the infection account for the majority of targets investigated for potential vaccines. Experimental vaccines targeting the pre-erythrocytic stages [the sporozoite injected by the mosquito, and the hepatic stage parasite) have encompassed a lesser diversity of parasite antigens]. This is the case despite the fact that experimentally induced sterile long-lasting immunity in humans has so far only been achieved through exposure to irradiated sporozoites. The acquisition and maintenance of this immunity depends on the use of invasive sporozoites and on the presence of developmentally arrested hepatic stage parasites.Read moreRead less