How Do Cross-reactive Memory B Cells Affect Influenza Vaccine Titers?
Funder
National Health and Medical Research Council
Funding Amount
$798,049.00
Summary
Influenza vaccines are updated frequently to protect against the highly variable influenza virus. Despite careful selection of vaccine viruses, most influenza vaccines provide only modest protection and protection is poor some years. In turn, the response to vaccination varies between individuals. This probably reflects complex and variable histories of influenza infection and vaccination. The project investigates how past influenza exposure influences vaccine responses and effectiveness.
Modelling The Effects Of Immunity On Influenza Transmission - Implications For Prevention And Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$275,767.00
Summary
There is uncertainty about how many people can be infected by a single person with influenza at the start of an outbreak. Some data suggest that a single generation of transmission can infect 10-20 other people. With such a rate of growth (ie 10-20 fold every 3 days) the spread of an influenza outbreak is virtually unstoppable. Other data suggest that each person with influenza infects less than 2 other people on average. With such a lower rate of growth, control would be more feasible. Our proj ....There is uncertainty about how many people can be infected by a single person with influenza at the start of an outbreak. Some data suggest that a single generation of transmission can infect 10-20 other people. With such a rate of growth (ie 10-20 fold every 3 days) the spread of an influenza outbreak is virtually unstoppable. Other data suggest that each person with influenza infects less than 2 other people on average. With such a lower rate of growth, control would be more feasible. Our project will use data from historic and contemporary outbreaks of influenza and build mathematical models to explain the rate of growth of an influenza outbreak in terms of: 1. The proportion of people exposed to influenza who do not become ill (although there can be evidence of infection if careful studies are made). This proportion is about 33%. 2. The proportion of people who are protected from influenza by immunity, whether induced by vaccination or by past exposure to natural influenza infection (this can vary from 0% in isolated populations which have not seen influenza for many years up to 80 or 90% in urbanised populations that are exposed to influenza almost every season). 3. Different rates of contact between different people and groups of people - some may be exposed so often that their immunity is boosted regularly without them becoming severely ill; others, living in more isolated circumstances, may be rarely exposed, but when they are, they are more likely to become severely ill. 4. The effects of influenza vaccine in inducing protective immunity - it is well known that there is good protection if the vaccine is well matched to the circulating virus. 5. The effects of live virus infection in inducing (short-lived) protection against a wider range of influenza viruses. Our model results will be used to guide vaccine design and pandemic planning.Read moreRead less
A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
The initiation and maintenance of plasma and platelet donation in Australia: An analysis of the role of donor identity and commitment. Australia strives to be self-sufficient in the provision of plasma and platelets in a context where demand is forecast to grow. Our research will be of significant social and applied benefit to Australia in identifying the key psychosocial determinants of plasma and platelet (apheresis) donation initiation and maintenance. In addition, our research will design an ....The initiation and maintenance of plasma and platelet donation in Australia: An analysis of the role of donor identity and commitment. Australia strives to be self-sufficient in the provision of plasma and platelets in a context where demand is forecast to grow. Our research will be of significant social and applied benefit to Australia in identifying the key psychosocial determinants of plasma and platelet (apheresis) donation initiation and maintenance. In addition, our research will design and assess practical interventions to facilitate the recruitment and retention of apheresis donors. Greater understanding of the determinants of apheresis donor behaviour will help to increase the numbers of Australians choosing to become regular apheresis donors. This will allow Australia to ultimately meet its goal of self-sufficiency in providing critical medical resources.Read moreRead less
Collective Engagement towards Social Purpose. This project aims to develop knowledge on how to engender collective engagement for a social purpose, such that the collective actions of the group facilitate well-being of the broader community. The project expects to generate new knowledge of how to drive the emergence of engagement from an individual to a collective level, and understand the benefits that can be gained by focusing this engagement on social purpose. Expected outcomes include measur ....Collective Engagement towards Social Purpose. This project aims to develop knowledge on how to engender collective engagement for a social purpose, such that the collective actions of the group facilitate well-being of the broader community. The project expects to generate new knowledge of how to drive the emergence of engagement from an individual to a collective level, and understand the benefits that can be gained by focusing this engagement on social purpose. Expected outcomes include measurement tools, an intervention framework for facilitating collective engagement, and mechanisms for leveraging this engagement for community well-being. This should provide significant benefits within organisations, by enhancing their social impact and facilitating economic growth and job creationRead moreRead less
Intelligent CRM through Conjoint Data Mining of Heterogeneous Sources. This project aims to investigate and develop techniques to improve customer relationship management (CRM) for public and private organisations. It aims to develop an intelligent framework to assist in adaptive marketing and management of customers. The framework is designed to manage multiple information resources for information sharing, and to synthesise knowledge through visualisation. Intended outcomes are standardised XM ....Intelligent CRM through Conjoint Data Mining of Heterogeneous Sources. This project aims to investigate and develop techniques to improve customer relationship management (CRM) for public and private organisations. It aims to develop an intelligent framework to assist in adaptive marketing and management of customers. The framework is designed to manage multiple information resources for information sharing, and to synthesise knowledge through visualisation. Intended outcomes are standardised XML profiles for the different data sets and business processes, novel techniques for conjoint mining of structured and semi-structured data, and adaptive business intelligence techniques. The results will be validated using large real-world data sets provided by the partner organisation.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Shrinking the food-print by creating consumer demand for sustainable and healthy eating. The negative impacts from the food choices made by many Australians are posing challenges to individual wellbeing and to maintaining a viable natural world. Drawing on innovative public health and consumer research, this project will identify opportunities for encouraging consumers to move towards more environmentally sustainable and healthy diets.
3D Printed Food for People with Swallowing Disability. This project aims to identify ways that 3D food printing (additive manufacturing using real food in a device like a ink-jet printer) could be used to improve the visual appeal of puree meals for people with swallowing difficulty, who make up ~8% of the world's population. This study will be the first to include people with swallowing disability (e.g., related to cerebral palsy, stroke, older age) and their supporters in examining the views a ....3D Printed Food for People with Swallowing Disability. This project aims to identify ways that 3D food printing (additive manufacturing using real food in a device like a ink-jet printer) could be used to improve the visual appeal of puree meals for people with swallowing difficulty, who make up ~8% of the world's population. This study will be the first to include people with swallowing disability (e.g., related to cerebral palsy, stroke, older age) and their supporters in examining the views and experiences of stakeholders on the impact of 3D food printing on quality of life, enjoyment, participation, and safety. Outcomes include new knowledge on factors affecting the implementation of 3D food printing in disability and aged care services, to inform policy, practice, and future research.Read moreRead less
Transforming Primary Healthcare Service Delivery: A Digital-Human Approach. This project aims to address the urgent need for a transformational shift in thinking and actions in primary healthcare service delivery. Primary care clinics, the front door of Australia's healthcare, are under considerable strain. By using a four-phase mixed methodology design across four Australian states, this project expects to generate a national evidence-based framework which takes a dual approach combining the us ....Transforming Primary Healthcare Service Delivery: A Digital-Human Approach. This project aims to address the urgent need for a transformational shift in thinking and actions in primary healthcare service delivery. Primary care clinics, the front door of Australia's healthcare, are under considerable strain. By using a four-phase mixed methodology design across four Australian states, this project expects to generate a national evidence-based framework which takes a dual approach combining the use of digital technology with humanness. Expected outcomes include the development of an Australian-first evidence-based digital resource kit, including two new tools, and a new co-designed roadmap to better facilitate this important change journey to enhance patient experience, employee wellbeing and clinic performance.
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