Translating Genetic Determinants Of Glaucoma Into Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
Glaucoma is the leading cause of irreversible blindness worldwide. By 2020, it will affect 80 million people, and in Australia over the next decade, the overall cost of glaucoma will reach $4.3 billion per annum. This Program will use genetic advances to personalise treatment. Blindness will be prevented in individuals at highest risk, new ways to treat patients will be developed, and better outcomes for patients will result from less treatment and monitoring of low risk cases.
Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
Discovery Early Career Researcher Award - Grant ID: DE140100320
Funder
Australian Research Council
Funding Amount
$394,371.00
Summary
Understanding cone photoreceptor migration and cell death mechanisms . Normal vision requires functional and correctly located cone photoreceptor cells. Many genetic mutations, however, impair the correct migration of these cells during development and ultimately cause cell death. This project will investigate, for the first time, the casual link between the migration of cone cells and activation of cell death mechanisms. A coordinated approach, using a range of molecular techniques, will be use ....Understanding cone photoreceptor migration and cell death mechanisms . Normal vision requires functional and correctly located cone photoreceptor cells. Many genetic mutations, however, impair the correct migration of these cells during development and ultimately cause cell death. This project will investigate, for the first time, the casual link between the migration of cone cells and activation of cell death mechanisms. A coordinated approach, using a range of molecular techniques, will be used to determine which factors are essential for normal development, correct spatial location and survival of cone photoreceptors within the mammalian retina. This will provide a major step forward in our knowledge of the processes involved in the spatial deployment of cones and the developmental organisation of the retina.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100217
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
In-Vivo Multispectral and X-ray Micro-CT Imaging: Founding a Western Australian small animal imaging core facility. The Western Australian Small Animal Imaging facility will provide wide access for the West Australian research community to a multimodality functional and dynamic core bioimaging facility to characterise in-vivo animal models, including extensive postgraduate research training. Wide-ranging research outcomes of national and community benefit include imaging tumour development, bone ....In-Vivo Multispectral and X-ray Micro-CT Imaging: Founding a Western Australian small animal imaging core facility. The Western Australian Small Animal Imaging facility will provide wide access for the West Australian research community to a multimodality functional and dynamic core bioimaging facility to characterise in-vivo animal models, including extensive postgraduate research training. Wide-ranging research outcomes of national and community benefit include imaging tumour development, bone metabolism (osteoporosis), neural function (Alzheimer's disease) and regeneration, and infection mechanisms in live animals, which will result in improvements in human health. Imaging and monitoring coral growth, fish age, and soil structure will improve the economics and sustainability of Australia's marine ecosystems and agricultural food production.Read moreRead less