I am a molecular virologist researching the host response to hepatitis C virus (HCV) infection with the aim of understanding how the liver clears HCV infection. An understanding of this process will hopefully lead to novel antiviral strategies to combat not only HCV but a broad range of other viral infections.
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Sharing values and the co-creation of brands: Towards a new consumer driven branding paradigm. The project proposes a paradigm shift from traditional image building towards a full understanding and integration of consumer values into a deliberate process of co-created brand meanings. Brands thus managed can become iconic and symbolic of consumers' existing subcultures or may even define micro-cultures of consumption of their own (as in the case of Harley Davidson).
Should managers understand t ....Sharing values and the co-creation of brands: Towards a new consumer driven branding paradigm. The project proposes a paradigm shift from traditional image building towards a full understanding and integration of consumer values into a deliberate process of co-created brand meanings. Brands thus managed can become iconic and symbolic of consumers' existing subcultures or may even define micro-cultures of consumption of their own (as in the case of Harley Davidson).
Should managers understand the process by which such co-created brands develop, more Australian brand success stories (eg. Rip Curl, Penfold's Grange) would evolve and be better placed to tap the increasingly diversified sub-cultural landscape that characterises the Australian marketplace and many of our major trading partners.
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Youth, religion and sexuality: digital media, school cultures, exemptions. This project aims to understand the knowledges and practices about sexuality and religion that form the everyday worlds of young people who are religious. This should provide significant new knowledge about a key time in the development of a young person’s identity via a nationwide, deep yet comparative approach. Expected outcomes include strategic health policy and curriculum development advice that responds to current d ....Youth, religion and sexuality: digital media, school cultures, exemptions. This project aims to understand the knowledges and practices about sexuality and religion that form the everyday worlds of young people who are religious. This should provide significant new knowledge about a key time in the development of a young person’s identity via a nationwide, deep yet comparative approach. Expected outcomes include strategic health policy and curriculum development advice that responds to current debates around religious exemptions to anti-discrimination law and creates better education and health care for religious and LGBTIQ+ youth. Benefits will include increased wellbeing for religious LGBTIQ+ youth, conservatively religious and newly arrived youth communities in Australia.Read moreRead less
Native fish stocking of rivers: discriminating between hatchery-reared and wild fish. Stocking of fish is widely used in attempts to restore native fish populations. Little is known of the fate of stocked fish or the effects of stocking on resident populations. We will develop and evaluate protocols for chemical marking of otoliths of hatchery-reared fish so that their source can be determined. Experimental stocking of hatchery-reared fish will be undertaken and population structure and sourc ....Native fish stocking of rivers: discriminating between hatchery-reared and wild fish. Stocking of fish is widely used in attempts to restore native fish populations. Little is known of the fate of stocked fish or the effects of stocking on resident populations. We will develop and evaluate protocols for chemical marking of otoliths of hatchery-reared fish so that their source can be determined. Experimental stocking of hatchery-reared fish will be undertaken and population structure and source of stocked versus wild fish determined in stocked and unstocked rivers. Natural chemical signatures will also help determine important recruitment areas. The outcomes will allow fisheries managers to make informed decisions regarding stocking strategies.Read moreRead less
Hepatitis C affects a quarter of a million Australians, causing insidious but progressive liver disease which culminates in liver failure or cancer. There is no vaccine and prevention programs have limited effectiveness, but new antiviral therapies now offer high rates of cure. This Program will evaluate strategies to improve the health of those affected and prevent new infections by better understanding of the virus and the body’s immune response, including scarring and liver cancer formation.
Australian Laureate Fellowships - Grant ID: FL140100260
Funder
Australian Research Council
Funding Amount
$2,775,898.00
Summary
Using ancient microbiomes and genomes to reconstruct human history. Using ancient microbiomes and genomes to reconstruct human history. This project aims to generate unique insights into the processes and history that produced the current distribution of modern humans and the bacteria we carry with us (our microbiome). The project will use combined signals of bacterial, genomic and climate data to reconstruct the impacts of migrations, changes in diet, environment, and health in different parts ....Using ancient microbiomes and genomes to reconstruct human history. Using ancient microbiomes and genomes to reconstruct human history. This project aims to generate unique insights into the processes and history that produced the current distribution of modern humans and the bacteria we carry with us (our microbiome). The project will use combined signals of bacterial, genomic and climate data to reconstruct the impacts of migrations, changes in diet, environment, and health in different parts of the world. A key aspect will be the creation of a program to map the genetic history of indigenous Australia, and the impacts of colonisation on indigenous people around the world. Research advances will be transferred to Early Career Researchers through an innovative program of workshops, and the resulting data will be used to create a new format for Australian genetic databases.Read moreRead less
Sound discrimination in embryos affects lifetime fitness. This project aims to investigate the role of prenatal sound discrimination on postnatal vocal learning and foraging breadth. The project expects to generate new knowledge in the area of neuroscience and psychology using an innovative approach to measure how embryos learn, and determine effects of prenatal vocal experience on the repertoire of postnatal behaviour. Expected outcomes include understanding biological mechanisms for effective ....Sound discrimination in embryos affects lifetime fitness. This project aims to investigate the role of prenatal sound discrimination on postnatal vocal learning and foraging breadth. The project expects to generate new knowledge in the area of neuroscience and psychology using an innovative approach to measure how embryos learn, and determine effects of prenatal vocal experience on the repertoire of postnatal behaviour. Expected outcomes include understanding biological mechanisms for effective learning across life stages that would be useful to develop novel approaches for non-invasive monitoring of embryonic cognition.Read moreRead less
Only at the movies: mapping the contemporary Australian cinema market. Only at the movies? is a three-year project that asks: What is the enduring appeal of cinemagoing and how is it changing? It will provide detailed analyses of formal film exhibition and distribution in Australia by combining economic, cultural and geospatial research with industry expertise.