Retroviral invasion of the koala genome: prevalence, transmission and role in immunosuppressive disease. Koalas are a national symbol yet many of their populations are in decline as a result of habitat loss and disease. Lymphoid cancers and opportunistic infections are significant diseases in both captive and wild koala populations. We previously demonstrated that the recently identified koala retrovirus is associated with lymphoid cancer in koalas. This project will determine the distribution o ....Retroviral invasion of the koala genome: prevalence, transmission and role in immunosuppressive disease. Koalas are a national symbol yet many of their populations are in decline as a result of habitat loss and disease. Lymphoid cancers and opportunistic infections are significant diseases in both captive and wild koala populations. We previously demonstrated that the recently identified koala retrovirus is associated with lymphoid cancer in koalas. This project will determine the distribution of the virus in Australia, the mechanism of its spread and its effect on the immune function of koalas. This research will provide a foundation for better management of captive koalas and for conservation of wild koalas.Read moreRead less
Biotechnology and epidemiology to control nodavirus in barramundi aquaculture. Production of farmed barramundi has increased more than 1200% in the NT since 2001 but is threatened by nodavirus infection. Three industry partners, Darwin Aquaculture Centre, Marine Harvest and Berrimah Veterinary Laboratory will collaborate with The University of Sydney to:
1. control nodavirus infection
2. develop new technologies to detect nodavirus using immunoassay and surface enhanced laser desorption ionis ....Biotechnology and epidemiology to control nodavirus in barramundi aquaculture. Production of farmed barramundi has increased more than 1200% in the NT since 2001 but is threatened by nodavirus infection. Three industry partners, Darwin Aquaculture Centre, Marine Harvest and Berrimah Veterinary Laboratory will collaborate with The University of Sydney to:
1. control nodavirus infection
2. develop new technologies to detect nodavirus using immunoassay and surface enhanced laser desorption ionisation mass spectroscopy (SELDI)
3. develop an integrated disease control strategy based on epidemiological survey data, and ensure that it is practical and able to be widely adopted
By this means growth targets for barramundi aquaculture in northern Australia will be achieved.
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Structural and functional investigations into a novel chemokine binding protein encoded by evolutionarily diverse alphaherpesviruses. The outcomes of this project will help control disease caused by alphaherpesviruses, including disease in livestock (horses and poultry) and wildlife (kangaroos and wallabies). This will enhance animal health and welfare and will also benefit the associated industries. Livestock industries are critically important to the Australian economy (equine and poultry indu ....Structural and functional investigations into a novel chemokine binding protein encoded by evolutionarily diverse alphaherpesviruses. The outcomes of this project will help control disease caused by alphaherpesviruses, including disease in livestock (horses and poultry) and wildlife (kangaroos and wallabies). This will enhance animal health and welfare and will also benefit the associated industries. Livestock industries are critically important to the Australian economy (equine and poultry industries annually contribute approximately $7.7 and $2.6 billion respectively to our GDP). Wildlife species are crucial to Australian ecosystems and feature in the Australian tourism industry. This project is expected to strengthen international research collaborations and further enhance Australia's reputation as a world-class leader in research and biotechnology.Read moreRead less
A New Recombinant Subunit Vaccine against Equine Herpesviruses 1 and 4. Equine herpesviruses 1 and 4 (EHV-1 and EHV-4) cause respiratory disease, abortion and myeloencephalitis in horse populations worldwide. Despite extensive use of whole virus vaccines, these two viruses continue to circulate among Australian horses and are a continuing threat to brading, and to racing performance. The current vaccines are expensive and are marked in Australia by an overseas company. The project will assess th ....A New Recombinant Subunit Vaccine against Equine Herpesviruses 1 and 4. Equine herpesviruses 1 and 4 (EHV-1 and EHV-4) cause respiratory disease, abortion and myeloencephalitis in horse populations worldwide. Despite extensive use of whole virus vaccines, these two viruses continue to circulate among Australian horses and are a continuing threat to brading, and to racing performance. The current vaccines are expensive and are marked in Australia by an overseas company. The project will assess the ability of a new subunit vaccine produced by recombinant DNA technology to 1) provide horses with high levels of protective immune responses and 2) to prevent or limit EHV-1 and EHV-4 infection following experimental challenge.Read moreRead less
Equine rhinitis A virus; molecular pathogenesis and methods for control. The horse industry in Australia is primarily based in rural locations and is a major contributor to the national economy both in terms of direct economic contribution to gross domestic product and as a major employer of people in regional Australia. The research proposed in this project will improve our understanding of the pathogenesis of a virus that causes respiratory disease in horses that is related to the virus that c ....Equine rhinitis A virus; molecular pathogenesis and methods for control. The horse industry in Australia is primarily based in rural locations and is a major contributor to the national economy both in terms of direct economic contribution to gross domestic product and as a major employer of people in regional Australia. The research proposed in this project will improve our understanding of the pathogenesis of a virus that causes respiratory disease in horses that is related to the virus that causes foot and mouth disease in ruminants and swine. The technology developed during this project would have a global market.Read moreRead less