Exercise As Medicine For Heart Failure: A Novel Intervention To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$665,585.00
Summary
Heart failure (HF) is a common, debilitating and expensive disease; prognosis remains poorer than for the most cancers. 30,000 Australians are diagnosed every year and 300,000 live with the HF, at an annual cost of ~$1Billion. Exercise training is effective therapy in HF, because it reverses many of the problems that contribute to the reduced lifespan and impaired quality of life of patients with HF. We will test an exciting new type of exercise that promising greater benefit, at lower risk.
Developmental Origins Of Adult Cardiovascular Disease: Vascular Health In The Raine Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,087,427.00
Summary
The Raine study is a unique long term experiment that has collected extensive pre-birth and childhood data in ~3000 young Australians, who are now 27 years old. We plan to measure the artery health of 1200 of these volunteers and to determine what factors, both before and after birth, influence the presence of early atherosclerosis in humans. This study will guide strategies aimed at early prevention of heart attacks and stroke in humans, by defining the major risk factors.
Transcriptional Control Of Blood Vessel Development By Sox18
Funder
National Health and Medical Research Council
Funding Amount
$468,564.00
Summary
Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of ....Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of fundamental importance in the health sciences to gain an understanding of how blood vessels form and regenerate. As a result of our collaborative research efforts, we have discovered a gene, Sox18, that appears to regulate blood vessel development by controlling the formation and-or behaviour of endothelial cells, which line the blood vessels and make them impermeable. Our research so far indicates that MICE WITH DEFECTS IN SOX18 DIE FROM VASCULAR DEFECTS, underlining the importance of this gene. THIS PROJECT IS CONCERNED WITH FINDING OUT HOW SOX18 WORKS - exactly what goes wrong in mice lacking this gene, whether Sox18 can influence endothelial cell behaviour in cell culture, how Sox18 comes to be active in endothelial cells, what genes are switched on by Sox18, and what genes Sox18 co-operates with in its role in endothelial cells. The answers to these questions will not only provide fundamental basic information about how blood vessels development is controlled, but also sow the seeds for possible future therapies in which blood vessel development could be stimulated (eg in wound healing) or suppressed (eg in tumour progression) through pharmaceutical intervention.Read moreRead less
Enhancing Clinical Management Of Paediatric Malaria In Endemic Areas With Transmission Of Multiple Plasmodium Species
Funder
National Health and Medical Research Council
Funding Amount
$867,511.00
Summary
Malaria remains a major problem for children in developing countries especially where different types of the disease are common. This set of complementary studies, based at an established research site in PNG aims to develop new treatment strategies for childhood malaria. A novel method of giving medicine via a spray under the tongue for sick children before arrival at hospital and modified dosing schedules of an old drug used for treating parasites hidden in the liver will be studied.
Smoking Cessation For Youth Project Booster And Cohort Tracking Study
Funder
National Health and Medical Research Council
Funding Amount
$135,550.00
Summary
Adolescence is a critical period for the establishment of adult drug use behaviours. If smoking does not commence in teenage years it is unlikely to occur. This innovative project not only continues to address tobacco control with this important age group but also builds on evidence from a randomised intervention trial involving over 4,000 Year 9 students tracked over two years. This project was called the Smoking Cessation for Youth Project (SCYP). Preliminary longitudinal analyses of the SCYP ....Adolescence is a critical period for the establishment of adult drug use behaviours. If smoking does not commence in teenage years it is unlikely to occur. This innovative project not only continues to address tobacco control with this important age group but also builds on evidence from a randomised intervention trial involving over 4,000 Year 9 students tracked over two years. This project was called the Smoking Cessation for Youth Project (SCYP). Preliminary longitudinal analyses of the SCYP data indicate that the intervention students were significantly less likely to smoke heavily (smoking five or more days per week) than the control group and that intervention students were also significantly less likely to have tried smoking than the control group. These results represent a world first in evidence that population-based smoking cessation interventions among teenagers can be successful. The proposed project will determine the extent to which these positive intervention effects are sustainable, two years post intervention, as our cohort moves into Year 12. In addition to tracking the possible decay of SCYP intervention effects, the proposed project will also measure the effects of a booster intervention delivered students when they are in Year 12 (2002). The Year 12 intervention will comprise an innovative self-help 'magazine style' booster and a supportive environmental intervention involving school nurses and local GPs. This proposal represents a cost-effective opportunity to measure the effectiveness of a Year 12 tobacco cessation booster intervention. Further data on tobacco smoking behaviour in 2002 will also enable us to determine how long the SCYP intervention appears to affect behaviour and whether 'boosters' are needed in later secondary school years to maintain the benefits.Read moreRead less
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
Coordination control of underactuated ocean vehicles for ocean forecasting. Australia is surrounded by oceans. Ocean forecasting is essential for effective and efficient operations on and within the ocean for a number of applications such as coastal zone management, military operations and scientific research. The successful completion of this project promises to put Australia in a leading position in this area. Due to the multi-disciplinary nature of this project, the project development will a ....Coordination control of underactuated ocean vehicles for ocean forecasting. Australia is surrounded by oceans. Ocean forecasting is essential for effective and efficient operations on and within the ocean for a number of applications such as coastal zone management, military operations and scientific research. The successful completion of this project promises to put Australia in a leading position in this area. Due to the multi-disciplinary nature of this project, the project development will also stimulate the development in many other areas such as new ocean vehicles, sensors and actuators, electronics and control.Read moreRead less
Distributionally robust dynamic optimisation for nonlinear switched system. Biochemical production utilising fermentation processes evidences poor product repeatability. This project aims to control and optimise 1,3-propanediol production via microbial fermentation. 1,3-propanediol is an essential ingredient for many polymeric materials and is present in cosmetics, personal care and cleaning products. New theory and parallel algorithms will be developed for the control and optimisation of the mi ....Distributionally robust dynamic optimisation for nonlinear switched system. Biochemical production utilising fermentation processes evidences poor product repeatability. This project aims to control and optimise 1,3-propanediol production via microbial fermentation. 1,3-propanediol is an essential ingredient for many polymeric materials and is present in cosmetics, personal care and cleaning products. New theory and parallel algorithms will be developed for the control and optimisation of the microbial fermentation of 1,3-propanediol production, where the bacteria kinetic parameters are uncertain without full knowledge of the probability distribution. This theory will also be applicable to other fermentation processes. The project outcomes are expected to significantly improve the productivity of the biochemical engineering industry involving fermentation processes.Read moreRead less
The Acoustic, Control and Aerodynamic Aspects of the Entecho Hoverpod. The development of small aerial vehicles, both manned and unmanned is a growing market in the aviation industry. This market sector has the potential to provide cheap, environmentally friendly transport solutions for the defence purposes, law enforcement agencies and emergency and recreational vehicles. This project serves to enhance Australia's position in this market by helping a local company develop its technology in a ....The Acoustic, Control and Aerodynamic Aspects of the Entecho Hoverpod. The development of small aerial vehicles, both manned and unmanned is a growing market in the aviation industry. This market sector has the potential to provide cheap, environmentally friendly transport solutions for the defence purposes, law enforcement agencies and emergency and recreational vehicles. This project serves to enhance Australia's position in this market by helping a local company develop its technology in a cost effective and timely manner. The progress made in the three research aspects will also advance areas of science and technology with practical applications other than aerial vehicles.Read moreRead less