Bioengineering Endovascular Prostheses With Proactive Biocompatibility
Funder
National Health and Medical Research Council
Funding Amount
$627,950.00
Summary
Metallic cardiovascular implants, such as stents, used in the treatment of heart disease are not compatible with blood. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of metal alloys, and shown a significant improvement in their compatibility. Stents coated using our technology stand to dramatically improve the treatment of cardiovascular disease.
Development Of Endovascular Stents With Proactive Biocompatibility
Funder
National Health and Medical Research Council
Funding Amount
$428,470.00
Summary
Metallic cardiovascular implants, such as stents, used in the treatment of heart disease are not compatible with blood. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of metal alloys, and shown a significant improvement in their compatibility. Stents coated using our technology stand to dramatically improve the treatment of cardiovascular disease.
Bioengineering Synthetic Elastin Conduits For Arterial Revascularisation
Funder
National Health and Medical Research Council
Funding Amount
$624,776.00
Summary
An arterial substitute with both physical and biological properties that mimic those of the human vasculature has long been the holy grail of vascular tissue engineering. We propose synthetic elastin can form the basis of a durable, clinically effective small diameter vascular graft and fill a significant unmet need for a biocompatible vascular substitute.
Biocompatible Synthetic Conduits To Treat Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$421,818.00
Summary
Clinically available synthetic conduits used in vascular repair and bypass are fundamentally incompatible with the vasculature. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of all polymeric materials and have shown a significant improvement in their compatibility. Grafts coated using our technology stand to dramatically improve the treatment of vascular diseas ....Clinically available synthetic conduits used in vascular repair and bypass are fundamentally incompatible with the vasculature. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of all polymeric materials and have shown a significant improvement in their compatibility. Grafts coated using our technology stand to dramatically improve the treatment of vascular disease.Read moreRead less
The emerging interdisciplinary field, mechanobiology, is focused on understanding how cells sense their surroundings and transfer biomechanical signals to initiate cellular changes. I aim to develop hydrogel platforms with differential stiffness patterns to study cellular mechanotransduction and to generate heart muscle cells. The findings have the potential to greatly improve the clinical outcomes where more than 10 clinical trials failed to show successful regeneration after heart attack.
Bioactivated Hierarchical Hydrogels As Zonal Implants For Articular Cartilage Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$353,161.00
Summary
Cartilage is frequently damaged, but does not repair on its own, and degenerates in osteoarthritis. Unfortunately, current treatments are also not able to regenerate the structure of normal cartilage and fail to restore joint function long-term. Our project, HydroZONES, brings together expertise from 16 partners to tackle this problem and regenerate cartilage with the appropriate structure to help the millions of people worldwide suffering from cartilage problems such as osteoarthritis.
Improving Bionic Device Safety And Performance With Conductive Hydrogels
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Bionic devices are being developed to treat a variety of neural disorders including blindness. Conductive hydrogels (CHs) are a new soft material developed by the CI to improve device performance and safety. This project will explore CH technologies with an aim of producing flexible organic electronics for high resolution devices, such as the bionic eye. Collaboration will be sought through industry, academia and clinical researchers to accelerate technology translation from bench to bedside.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.