Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Apoptosis And Stem Cells In Cancer Development And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$22,852,198.00
Summary
To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101501
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
Printed back electrodes enabling low-cost perovskite solar cells. This project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in rese ....Printed back electrodes enabling low-cost perovskite solar cells. This project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in research cells to large-area PSCs modules produced through industry-relevant, scalable, and low-cost printing and coating methods. This will provide significant benefits to Australian industry, from small to medium enterprises to larger utility power companies, while creating economic opportunities and enabling sustainable societies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100084
Funder
Australian Research Council
Funding Amount
$269,020.00
Summary
Flexible Flame Aerosol Synthesis Technology. Funding is requested to establish a world-leading fabrication facility for nanostructured materials via flame synthesis. This is a scalable fabrication route used for industrial production of most nanoparticle commodities. The aim is to advance current capabilities by providing control over the reaction environment and flame reaction sources. This will extend the range of feasible materials from the current metal oxides to a broad family of nitrides, ....Flexible Flame Aerosol Synthesis Technology. Funding is requested to establish a world-leading fabrication facility for nanostructured materials via flame synthesis. This is a scalable fabrication route used for industrial production of most nanoparticle commodities. The aim is to advance current capabilities by providing control over the reaction environment and flame reaction sources. This will extend the range of feasible materials from the current metal oxides to a broad family of nitrides, sulphides, and metal-organic frameworks, enabling the engineering of electrocatalysts, optoelectronic- and bio-materials. Benefits are expected in terms of fundamental and applied knowledge generation, with impact to the Australian industry sectors of Advanced Manufacturing, Energy and Health.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resou ....Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resource management for distributed VPPs. The anticipated benefits from this institutional level collaborations are that VPPs help in enhancing national power grid operations during normal and disruptive conditions when more renewables are connected and also secure benefits of consumers, prosumers, and grid operators.Read moreRead less
Revealing the atoms that control performance in photoactive perovskites. This project aims to develop new electron microscopy techniques that will unambiguously determine the elusive structures of photoactive perovskite compounds under static and operational conditions, while correlating crystal structure with solar cell device performance. Photoactive perovskites are promising photovoltaic materials, however, many are sensitive to air and irradiation. This has impeded a huge international resea ....Revealing the atoms that control performance in photoactive perovskites. This project aims to develop new electron microscopy techniques that will unambiguously determine the elusive structures of photoactive perovskite compounds under static and operational conditions, while correlating crystal structure with solar cell device performance. Photoactive perovskites are promising photovoltaic materials, however, many are sensitive to air and irradiation. This has impeded a huge international research effort to determine their structure reliably at the atomic scale. With these new techniques applied to leading compounds and devices, it is expected this project will reveal the structural effects controlling electrical properties and device performance and so enable the design of superior perovskite photovoltaics.Read moreRead less