Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
The Role Of Chemokines In Establishing HIV Latency
Funder
National Health and Medical Research Council
Funding Amount
$372,049.00
Summary
Although antiviral therapy is effective in controlling HIV, therapy must be continued life-long because the virus cannot be cleared from long lived infected CD4+ T cells that are silently or latently infected. In this proposal we will explore the mechanism of how HIV can enter these resting CD4+ T-cells and establish long lived latent infection. Understanding this process may potentially lead to new strategies to cure HIV infection.
Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less
A new defect-control approach for mismatched heteroepitaxy semiconductors. This project aims to develop a new defect-control approach for silicon-germanium heteroepitaxial semiconductor systems to provide a route for high-throughput, low-cost, high-efficiency silicon tandem solar cells. Mismatched heteroepitaxy of semiconductors is of considerable interest for fabricating novel devices. However, the use of highly-mismatched heteroepitaxial semiconductors has been limited due to the high densitie ....A new defect-control approach for mismatched heteroepitaxy semiconductors. This project aims to develop a new defect-control approach for silicon-germanium heteroepitaxial semiconductor systems to provide a route for high-throughput, low-cost, high-efficiency silicon tandem solar cells. Mismatched heteroepitaxy of semiconductors is of considerable interest for fabricating novel devices. However, the use of highly-mismatched heteroepitaxial semiconductors has been limited due to the high densities of crystal defects which degrade the performance of both majority and minority carrier devices. This project aims to develop a new defect-control approach for heteroepitaxial semiconductors by continuous wavelength diode laser processing. With heteroepitaxial silicon-germanium as an example, the project will investigate the mechanism underlying defect-cleaning, optimised designs for best performance, and designs for high-efficiency tandem solar cells.Read moreRead less
Kesterite solar cell coated architectural stainless steel. This project aims to develop cost-effective, high-performance kesterite architectural stainless steel coated with solar cells for application in roofing, skin and facades of smart buildings. The project will integrate expertise in producing kesterite solar cells with expertise in manufacturing new steel to eliminate toxic, scarce materials and high-cost processes employed in conventional solar-driven steel. The initial target of the proj ....Kesterite solar cell coated architectural stainless steel. This project aims to develop cost-effective, high-performance kesterite architectural stainless steel coated with solar cells for application in roofing, skin and facades of smart buildings. The project will integrate expertise in producing kesterite solar cells with expertise in manufacturing new steel to eliminate toxic, scarce materials and high-cost processes employed in conventional solar-driven steel. The initial target of the project would be to increase kesterite cell efficiency to beyond 10 per cent, and ultimately beyond 17 per cent, but still at a low cost.Read moreRead less
Stable Non-toxic Organic-inorganic Halide Perovskite Solar Cells. The project aims to develop next-generation organic-inorganic halide solar cells which are stable and non-toxic. Although rapid progress has been made in the emerging perovskite solar cell technology, it currently relies on lead as a key perovskite component. The elimination of lead from organic-inorganic halide perovskite solar cells would greatly increase their acceptance as an alternative thin film photovoltaic solution because ....Stable Non-toxic Organic-inorganic Halide Perovskite Solar Cells. The project aims to develop next-generation organic-inorganic halide solar cells which are stable and non-toxic. Although rapid progress has been made in the emerging perovskite solar cell technology, it currently relies on lead as a key perovskite component. The elimination of lead from organic-inorganic halide perovskite solar cells would greatly increase their acceptance as an alternative thin film photovoltaic solution because of their low cost and non-toxic nature. The dearth of lead-free perovskite solar cell demonstrations and the relatively low conversion efficiencies demonstrated understate their potential. This project plans to improve understanding of their photovoltaic enabling attributes by characterising and modelling their optical and electrical properties. It then plans to apply new fabrication methods to develop lead-free solar devices.Read moreRead less
Optimising experimental design for robust product development: a case study for high-efficiency energy generation. This project tackles key mathematical challenges to provide a powerful new methodology and tool for optimal product design, making smarter use of limited information, minimising costly trials, shortening the product cycle, and boosting the competitiveness of both the Australian manufacturing and alternative energy production industries.
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less