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Using transgenic plant-based production and delivery systems to develop an avian influenza vaccine. This project aims to provide proof-of-concept for the rapid production of plant-made vaccines of high strategic value to the poultry industry. Plant-made AI vaccines would help safeguard primary industries in Australia from exotic influenza strains and shield rural communities from the impact of stock losses. This collaboration will also contribute to the Molecular Farming industry by ensuring tha ....Using transgenic plant-based production and delivery systems to develop an avian influenza vaccine. This project aims to provide proof-of-concept for the rapid production of plant-made vaccines of high strategic value to the poultry industry. Plant-made AI vaccines would help safeguard primary industries in Australia from exotic influenza strains and shield rural communities from the impact of stock losses. This collaboration will also contribute to the Molecular Farming industry by ensuring that Australian interests are considered as this frontier technology tackles the challenges of turning academic research into marketable products. The key features of an oral plant-made AI vaccine, including rapid and non-egg based production, also make this an attractive technology for the future development of swine and human influenza vaccines.Read moreRead less
Plant Cells for Improved Oral Delivery of Vaccines. The pharmaceutical industry is ever assessing methods of improved delivery of their valuable vaccines, pharmaceuticals and nutraceuticals. The oral route increases ease of delivery, is less expensive, and has increased patient compliance. It may also allow vaccination of free-ranging animal populations that may otherwise go untreated. Optimizing oral delivery of plant-made, valuable proteins will therefore have broad ramifications to animal and ....Plant Cells for Improved Oral Delivery of Vaccines. The pharmaceutical industry is ever assessing methods of improved delivery of their valuable vaccines, pharmaceuticals and nutraceuticals. The oral route increases ease of delivery, is less expensive, and has increased patient compliance. It may also allow vaccination of free-ranging animal populations that may otherwise go untreated. Optimizing oral delivery of plant-made, valuable proteins will therefore have broad ramifications to animal and human health industries, enhancing use of existing valuable compounds and creating opportunities for new compounds and user groups including wild and domesticated animals.Read moreRead less
Efficient organelle transformation. Chloroplasts and mitochondria are the powerhouses of plant and animal cells. Ability to express introduced genes in these organelles has enormous biotechnological potential in agriculture and medicine, but practical development has been almost stalled for 15 years by very low transformation efficiency. Plastid transformation is today routine only in tobacco; and mitochondrial transformation has been achieved only in yeasts and algae. We have developed a soluti ....Efficient organelle transformation. Chloroplasts and mitochondria are the powerhouses of plant and animal cells. Ability to express introduced genes in these organelles has enormous biotechnological potential in agriculture and medicine, but practical development has been almost stalled for 15 years by very low transformation efficiency. Plastid transformation is today routine only in tobacco; and mitochondrial transformation has been achieved only in yeasts and algae. We have developed a solution, and achieved the key technical requirements for proof of concept. This collaboration between industry, government and university partners will deliver key Australian-owned IP, for environmentally-friendly plant biofactories, and for treatment of mitochondrial genetic disorders.Read moreRead less