Multifunctional biodegradable nanoparticles for enhanced DNA vaccine delivery. DNA vaccine, which shows better immunological and economic merits than conventional vaccines, suffers clinical failure due to the difficulty of delivering intact DNA molecules to relevant cells. This project seeks to develop smart polymer nanospheres to protect the DNA molecules from premature degradation in order to improve its efficacy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989341
Funder
Australian Research Council
Funding Amount
$690,000.00
Summary
Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nan ....Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nanomaterials and their interaction with biosystems. The equipment will facilitate the development of new materials that are expected to underpin advances in drug delivery, diagnostics and implant devices, further strengthening Australia's strong reputation in these areas.Read moreRead less
Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within th ....Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within the Designated Research Priority of Frontier Technologies for Building and Transforming Australian Industries. Read moreRead less
Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychologica ....Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons. This project will lead to a more efficient and reliable drug delivery system to treat Huntington's disease. The insights and technology gained from this project will be directly applicable for many human diseases, both within and outside the central nervous system. This project will make a major contribution to the ARC's goal of maintaining good health and promises to significantly reduce the financial and psychological burdens to patients' family and community. This project will encourage inter-disciplinary approaches to research and train highly skilled researchers both in neuroscience and nanobiotechnology to advance Australia's industrial competitiveness.Read moreRead less
Feasibility Studies of Using AC Electrospraying for Biomaterials Synthesis. The proposed interdisciplinary research is anticipated to benefit workers in academia and industry as well as clinicians and patients. Given the demand for point-of-care drug delivery, micro/nano-encapsulation and biomaterials synthesis, the research will be beneficial to the pharmaceutical industry and spin-off/start-up microfluidic businesses interested in commercially developing these devices. It is intended that the ....Feasibility Studies of Using AC Electrospraying for Biomaterials Synthesis. The proposed interdisciplinary research is anticipated to benefit workers in academia and industry as well as clinicians and patients. Given the demand for point-of-care drug delivery, micro/nano-encapsulation and biomaterials synthesis, the research will be beneficial to the pharmaceutical industry and spin-off/start-up microfluidic businesses interested in commercially developing these devices. It is intended that the work will improve quality of life by advancing biomaterials technology and by making medical treatment more readily accessable, portable and more efficient. For patients, the proposed drug delivery device can help prevent sudden initial bursts of dose during administration, which could potentially have fatal consequences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775612
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the de ....Nanomaterials Optical Characterisation Facility. Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However, the small length scales involved present significant challenges with regard to characterising the nanomaterials produced. The Nanomaterials Optical Characterisation facility will provide state-of-the-art equipment for examining the properties of nanomaterials. The equipment will be pivotal in assisting the development of next-generation medicines, implants, optical devices and surface coatings, further strengthening Australia's formidable reputation in these areas.Read moreRead less
Fundamentals and applications of continuous-flow microprocessing systems based on supercritical fluids and gas expanded liquids. Microchemical systems have considerable potential in the area of chemical discovery and development. Practical application of these systems requires fundamental understanding and strategies for conversion to appropriate scale. The aim of this project is to overcome such challenges in the development of microstructured continuous-flow technology.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989471
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Facility for innovation in structural biomaterials engineering. Biomaterials are used in a diverse range of environments that impact on the way that all Australians live. The Facility for Innovation in Structural Biomaterials Engineering will greatly assist researchers to undertake cross-disciplinary projects aimed at improving human health eg. smart materials that assist stem cell therapies for treating deafness and spinal cord injuries, as well the way we live eg. more durable building materia ....Facility for innovation in structural biomaterials engineering. Biomaterials are used in a diverse range of environments that impact on the way that all Australians live. The Facility for Innovation in Structural Biomaterials Engineering will greatly assist researchers to undertake cross-disciplinary projects aimed at improving human health eg. smart materials that assist stem cell therapies for treating deafness and spinal cord injuries, as well the way we live eg. more durable building materials for a sustainable national infrastructure. The facility will help Australia remain at the forefront of these high priority areas and see both individuals and industry benefit from advanced biomaterial products.Read moreRead less
Biodegradable immuno-therapeutic nanoparticles. The national benefit relates directly to Promoting and Maintaining Good Health through preventative healthcare as this project will develop a new vaccine delivery platform that will contribute to preventing a host of diseases such as viral infections and malaria. The health benefits of better vaccines directly enhance a Healthy Start to Life and Ageing Well. This area of nanoparticle therapies is a global 'hot spot' and this multi-disciplinary team ....Biodegradable immuno-therapeutic nanoparticles. The national benefit relates directly to Promoting and Maintaining Good Health through preventative healthcare as this project will develop a new vaccine delivery platform that will contribute to preventing a host of diseases such as viral infections and malaria. The health benefits of better vaccines directly enhance a Healthy Start to Life and Ageing Well. This area of nanoparticle therapies is a global 'hot spot' and this multi-disciplinary team could make huge and rapid progressions in this area of therapeutics. New intellectual property in the area of therapeutic particle production is the cornerstone of this project and could deliver lasting economic benefits through the creation of new health products and patents.Read moreRead less