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Immunogenicity Of 23-valent Pneumococcal Polysaccharide Vaccination Among Indigenous Australian Adolescents And Adults
Funder
National Health and Medical Research Council
Funding Amount
$674,738.00
Summary
Multiple doses of pneumococcal vaccine are recommended for Indigenous Australians under a unique schedule aimed at reducing high rates of pneumococcal disease. However, disease rates have not reduced after several years of the program. This study examines a key, previously unstudied explanation for the lack of disease reduction in this population: that repeated vaccination could produce suboptimal protection against disease. It will provide evidence to underpin future vaccination policy.
Vaccine And Antibiotic Selective Pressures On The Microbiology Of Otitis Media In Aboriginal And Torres Strait Islander Children In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$88,502.00
Summary
Investigating the influence that pneumococcal vaccines and specific antibiotics have on the bacteria in the nose which cause otitis media (OM), to determine the most effective prevention and treatments to reduce OM in Indigenous children.
Reducing Disparities In Cervical Cancer Incidence For Aboriginal And Torres Strait Islander Women Through Screening And Vaccination
Funder
National Health and Medical Research Council
Funding Amount
$329,768.00
Summary
This program of research will aim to reduce cervical cancer incidence for Indigenous women by developing and trialling health systems interventions to increase cervical screening participation and HPV vaccination coverage. This research will be led by an Indigenous researcher with Indigenous people and for Indigenous people.
Reducing The Community Burden Of Respiratory Infections In Indigenous Children
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Lower respiratory infections are the leading cause of preventable mortality among Indigenous children in the Northern Territory. Streptococcus pneumoniae remain one of the major paediatric respiratory pathogens. In this proposal I will describe the impact of past and present pneumococcal vaccination strategies on the burden of infant respiratory infections in this region.
Pneumococcal Conjugate Vaccine (PCV) Schedules For The Northern Territory (NT): Randomised Controlled Trial Of Booster Vaccines To Broaden And Strengthen Protection From Invasive And Mucosal Infections.
Funder
National Health and Medical Research Council
Funding Amount
$2,078,861.00
Summary
Very few Indigenous children in remote communities have healthy ears or lungs; almost 20% have eardrum perforations. The associated hearing loss causes educational disadvantage with life long impacts on quality of life. New pneumococcal conjugate vaccines target a broader diversity of pathogens that cause eardrum perforation and lung infections, but the best schedules and combinations have not been tested. This randomised controlled trial will compare immune response, bacterial carriage and clin ....Very few Indigenous children in remote communities have healthy ears or lungs; almost 20% have eardrum perforations. The associated hearing loss causes educational disadvantage with life long impacts on quality of life. New pneumococcal conjugate vaccines target a broader diversity of pathogens that cause eardrum perforation and lung infections, but the best schedules and combinations have not been tested. This randomised controlled trial will compare immune response, bacterial carriage and clinical outcomes of different vaccine schedules.Read moreRead less