Effective Treatment Of Ureaplasma To Prevent Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$701,652.00
Summary
Premature births are often due to infection in the uterus by microorganisms named Ureaplasmas. Antibiotics given to the mother fails to eradicate them, probably because of poor passage of the drug across the placenta. This project asks if antibiotics should instead be given as a single injection into the amniotic fluid. Clinical studies will evaluate the frequency and types of Ureaplasmas in amniotic fluid. Studies with sheep will work out which antibiotic would be most effective and at which ro ....Premature births are often due to infection in the uterus by microorganisms named Ureaplasmas. Antibiotics given to the mother fails to eradicate them, probably because of poor passage of the drug across the placenta. This project asks if antibiotics should instead be given as a single injection into the amniotic fluid. Clinical studies will evaluate the frequency and types of Ureaplasmas in amniotic fluid. Studies with sheep will work out which antibiotic would be most effective and at which route and dose.Read moreRead less
Intrauterine Ureaplasma Infection During Pregnancy: Fetal Effects And Characteristics Of Ureaplasma Pathogenicity.
Funder
National Health and Medical Research Council
Funding Amount
$527,097.00
Summary
Ureaplasmas are microorganisms that are commonly found in the urinary tracts of men and women, without any apparent adverse effects; but their presence in amniotic fluid during pregnancy is associated with preterm birth and other adverse pregnancy outcomes. The effects that ureaplasmas in the amniotic fluid have on the developing baby before birth are likely to result in illness after birth, but the range of potential effects is unknown. We also know very little about how ureaplasmas themselves ....Ureaplasmas are microorganisms that are commonly found in the urinary tracts of men and women, without any apparent adverse effects; but their presence in amniotic fluid during pregnancy is associated with preterm birth and other adverse pregnancy outcomes. The effects that ureaplasmas in the amniotic fluid have on the developing baby before birth are likely to result in illness after birth, but the range of potential effects is unknown. We also know very little about how ureaplasmas themselves manage to infect the fetus and other tissues within the pregnant uterus. Our studies are designed to identify the effects that ureaplasmas in amniotic fluid have on the developing fetus and how common treatments during pregnancy impact on those effects. We will also study ureaplasmas to see what it is about them that allows them to affect the fetus and other uterine tissues. We expect that our studies will lead to better diagnosis and treatment of amniotic ureaplasma infection during pregnancy, and will allow us to better care for babies born after exposure to ureaplasmas before birth.Read moreRead less