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Obstructive Sleep Apnoea Phenotypes And Treatment In Quadriplegia
Funder
National Health and Medical Research Council
Funding Amount
$599,635.00
Summary
Losing function in your arms and legs after an injury (quadriplegia) is a catastrophic event. Quadriplegia also results in obstructive sleep apnoea; a condition where the throat closes repeatedly while asleep causing sleepiness, poor concentration and cardiovascular diseases like stroke. Despite most people with quadriplegia having this disease, the cause is unknown. This project will thoroughly investigate obstructive sleep apnoea causes in people with quadriplegia and test a possible treatment
Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
The separation of carbon dioxide from industrial sources using nanoporous carbon. Carbon nanotubes and nanoporous carbon membranes offer the possibility of low cost energy efficient separations of gas mixtures. Possible applications include the purification of greenhouse gases for sequestration and the purification of hydrogen from reformer gas for use in a hydrogen energy economy. The proposed project involves the development of mathematical models and computer simulations to understand and ....The separation of carbon dioxide from industrial sources using nanoporous carbon. Carbon nanotubes and nanoporous carbon membranes offer the possibility of low cost energy efficient separations of gas mixtures. Possible applications include the purification of greenhouse gases for sequestration and the purification of hydrogen from reformer gas for use in a hydrogen energy economy. The proposed project involves the development of mathematical models and computer simulations to understand and optimise the nanoporous structure for different gas separations, and experimental research to produce the carbon nanoporous materials and determine their effectiveness of gas separation.Read moreRead less
A Network Of Sites And ‘up-skilled’ Therapists To Deliver Best Practice Stroke Rehabilitation Of The Upper Limb.
Funder
National Health and Medical Research Council
Funding Amount
$955,910.00
Summary
We aim, through our partnership, to bring better therapy to more stroke survivors. Effective therapies are available to improve hand function but survivors are not currently receiving these. We will systematically address this evidence-practice gap using knowledge-transfer methods to up-skill therapists and change practice behaviours. A network of sites and up-skilled therapists will deliver this therapy and sustain change. A template will guide future translational activities.
Ventilation Heterogeneity And Airway Remodelling In Asthma
Funder
National Health and Medical Research Council
Funding Amount
$522,586.00
Summary
Asthma is a common and important as a cause of significant symptoms and even death. Associated with asthma is narrowing and stiffening of the arways which causes uneven ventilation of the lungs and reduced lung function. We have developed a new technique of imaging the lungs, as well as new lung function tests which measure uneven ventilation and stiffening of airways. This will help us design better medications, and help predict those who are at risk or severe asthma and death.
Atomically thin membranes to transform chemical separations. Energy-efficient chemical separation is at the heart of modern resource and manufacturing industries, central to a prosperous and sustainable Australia. This project aims to develop next generation membrane technologies to transform chemical separations by employing recent breakthrough in materials discovery and nanofluidics. Expected outcomes include new fundamental understandings on sub-continuum transport physics and new atomically ....Atomically thin membranes to transform chemical separations. Energy-efficient chemical separation is at the heart of modern resource and manufacturing industries, central to a prosperous and sustainable Australia. This project aims to develop next generation membrane technologies to transform chemical separations by employing recent breakthrough in materials discovery and nanofluidics. Expected outcomes include new fundamental understandings on sub-continuum transport physics and new atomically thin membranes that enable energy-efficient separations for processing challenging streams beyond water purification. This project aims to position Australia at the forefront of sustainable separation technology and make the local resource and manufacturing industries more sustainable and globally competitive.Read moreRead less
Identifying The Microbiological Risk Factors For Acute Lower Respiratory Infection In Indigenous Children To Inform Future Intervention Strategies
Funder
National Health and Medical Research Council
Funding Amount
$495,745.00
Summary
Lung infections such as pneumonia are common in Indigenous children, and can lead to repeated hospitalisation and permanent lung damage. They are also an important cause of preventable death in children. This study will look at the role of bacteria and viruses in lung infections, and will inform interventions to reduce the burden and consequences of lung infections in Indigenous children.
Revolutionising The Diagnosis And Monitoring Of CF Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$818,391.00
Summary
Cystic fibrosis (CF) lung disease starts early in childhood and relentlessly progresses, with early death a common outcome. There is currently no method capable of detecting very early disease onset nor directly assessing the effectiveness of putative treatments. This project will apply our globally unique X-ray imaging tools, which are capable of imaging lung function at any point across the entire lung, for the very early detection of CF and assessment of clinically applicable treatments.
Optimising Non-invasive Ventilation At Birth For Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$735,912.00
Summary
Infants born very premature require respiratory support at birth to make the transition to newborn life. As these infants are very immature and prone to injury, modern respiratory care strategies utilise the least invasive approaches mainly applied using a facemask. However, we have discovered that the larynx is closed at birth and thereby prevents air from entering the lung. This application is focussed on optimising the efficiency of facemask ventilation at birth and stimulating breathing.
Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive indu ....Enabling low greenhouse gas emissions from road vehicles through the proper use of alternative fuels. A major increase in alternative transport fuel use appears necessary in our response to the challenges of climate change and energy security. This proposal will advance our fundamental understanding of key aspects of the combustion of particular alternative fuels, thus enabling proper engine design and so maximising greenhouse and energy security benefits. Further, the Australian automotive industry is a major employer and exporter, and needs to develop and/or maintain international leadership in low emission technologies to ensure its long term viability. This proposal builds a consortium of local organisations with common interests, thus helping local industry respond to several, significant challenges that they presently face.Read moreRead less